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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046360
UUCD1 version UUC-HoS-00747
Ensembl Protein ID ENSP00000245663.3
UniProt Accession Q86UZ6; E1P5K9; Q5JWJ3; Q6GMV4; Q9BQK3; Q9H3Z8; Q9H3Z9; ZBT46_HUMAN
Genbank Protein ID CAI21885.1; EAW75205.1; EAW75206.1; AAH52269.1; AAH73800.1
Protein Name Zinc finger and BTB domain-containing protein 46; BTB-ZF protein expressed in effector lymphocytes; BTB/POZ domain-containing protein 4; Zinc finger protein 340
Genbank Nucleotide ID AL121845; CH471077; CH471077; BC052269; BC073800
Gene Name ZBTB46; BTBD4; ZNF340
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000130584.10 ENST00000245663.8 ENSP00000245663.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
UniProtBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 1.90e-11 45.8 31 97
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd.vqpevfrallkFlYtgklde 67
           +Dv++vv+g++f+ahk vL  sS++F+ l  +  + s++   +++ d v ++ f+a+++F+Y+  l +
   Q: 31   CDVCVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSEQATVTHL-DiVTAQGFKAIIDFMYSAHLAL 97
           9*****************************887777763444444.66**************998865 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Function as a transcriptional repressor for PRDM1.
 Function as a transcriptional repressor for PRDM1.
Protein Sequence
(Fasta)
MNNRKEDMEI TSHYRHLLRE LNEQRQHGVL CDVCVVVEGK VFKAHKNVLL GSSRYFKTLY 60
CQVQKTSEQA TVTHLDIVTA QGFKAIIDFM YSAHLALTSR NVIEVMSAAS FLQMTDIVQA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046360|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GACGGACGGA CGGACGGACC GAGCAGCCCC GGCGAGCGCG CAGCTCGGAC CCGCCCGGAC 60
GCAGCGCCCT CCCGGCGGCG GCGGCGATCA CCGGCGCCGG CCCGGCGGCC GCGGCGCCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046360|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0003676--F:nucleic acid binding
GO:2001199--P:negative regulation of dendritic cell differentiation
GO:0030853--P:negative regulation of granulocyte differentiation
GO:0045650--P:negative regulation of macrophage differentiation
GO:0045656--P:negative regulation of monocyte differentiation
GO:2001200--P:positive regulation of dendritic cell differentiation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG hsa:140685
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002267 Ailuropoda melanoleuca 90.11 0.00e+00 920.00
IUUC-Apl-004220 Anas platyrhynchos 85.03 0.00e+00 957.00
IUUC-Aca-005350 Anolis carolinensis 76.79 0.00e+00 932.00
IUUC-Ame-011334 Astyanax mexicanus 61.01 0.00e+00 716.00
IUUC-Bta-012773 Bos taurus 85.47 0.00e+00 941.00
IUUC-Cja-019261 Callithrix jacchus 84.32 0.00e+00 899.00
IUUC-Cfa-021070 Canis familiaris 91.65 0.00e+00 765.00
IUUC-Cpo-021350 Cavia porcellus 92.62 0.00e+00 1013.00
IUUC-Csa-023182 Chlorocebus sabaeus 98.64 0.00e+00 1075.00
IUUC-Cin-025354 Ciona intestinalis 40.17 1.00e-22 102.00
IUUC-Csv-026323 Ciona savignyi 40.00 2.00e-23 104.00
IUUC-Dre-027453 Danio rerio 62.46 0.00e+00 729.00
IUUC-Dno-029375 Dasypus novemcinctus 86.25 0.00e+00 687.00
IUUC-Dor-030991 Dipodomys ordii 74.16 0.00e+00 770.00
IUUC-Eca-033346 Equus caballus 91.21 0.00e+00 988.00
IUUC-Eeu-034489 Erinaceus europaeus 84.77 0.00e+00 711.00
IUUC-Fca-035853 Felis catus 89.10 0.00e+00 973.00
IUUC-Fal-037546 Ficedula albicollis 83.52 0.00e+00 932.00
IUUC-Gmo-038589 Gadus morhua 83.33 1.00e-72 265.00
IUUC-Gga-040354 Gallus gallus 84.50 0.00e+00 939.00
IUUC-Ggo-045007 Gorilla gorilla 99.63 0.00e+00 1067.00
IUUC-Itr-048566 Ictidomys tridecemlineatus 84.86 0.00e+00 976.00
IUUC-Lch-050668 Latimeria chalumnae 74.54 0.00e+00 862.00
IUUC-Loc-052410 Lepisosteus oculatus 68.46 0.00e+00 801.00
IUUC-Laf-054523 Loxodonta africana 89.14 0.00e+00 953.00
IUUC-Mcc-055030 Macaca mulatta 99.01 0.00e+00 1020.00
IUUC-Meu-056772 Macropus eugenii 82.20 0.00e+00 997.00
IUUC-Mga-059531 Meleagris gallopavo 83.03 0.00e+00 914.00
IUUC-Mmr-061653 Microcebus murinus 89.81 0.00e+00 1023.00
IUUC-Mdo-062023 Monodelphis domestica 81.24 0.00e+00 1001.00
IUUC-Mmu-063957 Mus musculus 87.69 0.00e+00 1038.00
IUUC-Mpu-065784 Mustela putorius furo 87.52 0.00e+00 970.00
IUUC-Mlu-067188 Myotis lucifugus 86.33 0.00e+00 944.00
IUUC-Nle-069839 Nomascus leucogenys 97.29 0.00e+00 963.00
IUUC-Ont-071549 Oreochromis niloticus 67.52 0.00e+00 714.00
IUUC-Oan-073288 Ornithorhynchus anatinus 78.71 0.00e+00 987.00
IUUC-Ocu-074031 Oryctolagus cuniculus 66.61 0.00e+00 692.00
IUUC-Ola-087013 Oryzias latipes 66.55 0.00e+00 711.00
IUUC-Oga-089158 Otolemur garnettii 89.30 0.00e+00 984.00
IUUC-Oar-090145 Ovis aries 82.05 0.00e+00 778.00
IUUC-Ptr-090525 Pan troglodytes 98.98 0.00e+00 1063.00
IUUC-Pan-092450 Papio anubis 98.81 0.00e+00 1069.00
IUUC-Psi-093791 Pelodiscus sinensis 79.90 0.00e+00 971.00
IUUC-Pfo-096728 Poecilia formosa 63.06 0.00e+00 696.00
IUUC-Pab-098690 Pongo abelii 98.97 0.00e+00 986.00
IUUC-Pva-103107 Pteropus vampyrus 84.80 0.00e+00 688.00
IUUC-Rno-104885 Rattus norvegicus 87.38 0.00e+00 1030.00
IUUC-Sha-107445 Sarcophilus harrisii 81.07 0.00e+00 998.00
IUUC-Sar-113744 Sorex araneus 79.36 9.00e-174 602.00
IUUC-Tgu-117181 Taeniopygia guttata 83.52 0.00e+00 936.00
IUUC-Tru-117668 Takifugu rubripes 61.64 0.00e+00 708.00
IUUC-Tsy-119528 Tarsius syrichta 92.46 3.00e-166 578.00
IUUC-Tni-120403 Tetraodon nigroviridis 82.39 2.00e-66 246.00
IUUC-Tbe-128061 Tupaia belangeri 73.46 2.00e-168 584.00
IUUC-Ttr-128681 Tursiops truncatus 90.34 0.00e+00 829.00
Created Date 25-Jun-2017

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