iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046918

UUCD1 version

UUC-HoS-00411

Ensembl Protein ID

ENSP00000273067.3

UniProt Accession

Q9P2E8; Q4KMN7; Q86WR8; MARH4_HUMAN

Genbank Protein ID

BAA92637.1; AAH48793.1; AAH98448.1

Protein Name

E3 ubiquitin-protein ligase MARCH4; Membrane-associated RING finger protein 4; Membrane-associated RING-CH protein IV; RING finger protein 174; RING-type E3 ubiquitin transferase MARCH4

Genbank Nucleotide ID

AB037820; BC048793; BC098448

Gene Name

MARCH4; KIAA1399; RNF174

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000144583.4	ENST00000273067.4	ENSP00000273067.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
miRTarBase	microRNA	TRANSFAC	TargetScan
miRecords	RepTar	miRcode	RAID2
Protein-protein Interaction
iRefIndex	Mentha
Disease-associated Information
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17686993

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MLMPLCGLLW WWWCCCSGWY CYGLCAPAPQ MLRHQGLLKC RCRMLFNDLK VFLLRRPPQA 60
PLPMHGDPQP PGLAANNTLP ALGAGGWAGW RGPREVVGRE PPPVPPPPPL PPSSVEDDWG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCACCTCGG CCACACTGCT TCGCTCCCCC CTCCCCACCT TCAGCTGGCA CCGCAAACAA 60
GCCTTACCTC GTTGCATCTG CGAGGAGAGG TAGCAACAGC GAGCCTAGCC AGCCAGAGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033275--MARCH-like
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51292--ZF_RING_CH

Pfam

PF12906--RINGv

SMART

SM00744--RINGv

Gene Ontology

GO:0000139--C:Golgi membrane
GO:0005795--C:Golgi stack
GO:0016021--C:integral component of membrane
GO:0005802--C:trans-Golgi network
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

KEGG

hsa:57574

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001891	Ailuropoda melanoleuca	92.47	3.00e-180	624.00
IUUC-Aca-004387	Anolis carolinensis	80.00	6.00e-77	279.00
IUUC-Bta-012464	Bos taurus	87.45	2.00e-122	431.00
IUUC-Cja-019551	Callithrix jacchus	98.45	0.00e+00	670.00
IUUC-Cfa-020632	Canis familiaris	92.29	0.00e+00	631.00
IUUC-Cpo-021989	Cavia porcellus	91.97	2.00e-175	608.00
IUUC-Csa-023116	Chlorocebus sabaeus	98.45	0.00e+00	666.00
IUUC-Cho-024369	Choloepus hoffmanni	89.46	0.00e+00	630.00
IUUC-Cin-025794	Ciona intestinalis	35.71	1.00e-31	129.00
IUUC-Csv-026342	Ciona savignyi	36.02	2.00e-29	122.00
IUUC-Dre-028502	Danio rerio	55.76	3.00e-112	398.00
IUUC-Dno-028874	Dasypus novemcinctus	90.27	3.00e-172	598.00
IUUC-Dor-030725	Dipodomys ordii	76.88	1.00e-125	442.00
IUUC-Eca-033517	Equus caballus	93.57	3.00e-172	597.00
IUUC-Eeu-034758	Erinaceus europaeus	88.95	5.00e-168	583.00
IUUC-Fca-035463	Felis catus	92.75	1.00e-171	595.00
IUUC-Fal-036690	Ficedula albicollis	78.31	4.00e-121	427.00
IUUC-Gmo-039433	Gadus morhua	68.50	1.00e-101	363.00
IUUC-Gga-040630	Gallus gallus	84.56	8.00e-134	469.00
IUUC-Gac-042616	Gasterosteus aculeatus	69.12	6.00e-105	374.00
IUUC-Ggo-045073	Gorilla gorilla	99.74	0.00e+00	643.00
IUUC-Lch-049497	Latimeria chalumnae	80.25	2.00e-108	384.00
IUUC-Loc-051876	Lepisosteus oculatus	70.00	3.00e-96	345.00
IUUC-Laf-054047	Loxodonta africana	93.32	0.00e+00	645.00
IUUC-Mcc-055218	Macaca mulatta	98.70	0.00e+00	671.00
IUUC-Meu-056883	Macropus eugenii	84.94	1.00e-158	552.00
IUUC-Mga-059842	Meleagris gallopavo	84.52	3.00e-116	410.00
IUUC-Mvi-060405	Microbotryum violaceum	36.84	2.00e-10	60.80
IUUC-Mmr-061536	Microcebus murinus	94.56	3.00e-174	604.00
IUUC-Mdo-062808	Monodelphis domestica	82.10	1.00e-148	519.00
IUUC-Mmu-064281	Mus musculus	90.41	2.00e-166	578.00
IUUC-Mpu-066588	Mustela putorius furo	92.75	1.00e-171	595.00
IUUC-Mlu-067794	Myotis lucifugus	93.08	4.00e-168	583.00
IUUC-Ncr-068689	Neurospora crassa	36.84	5.00e-08	52.00
IUUC-Nle-069484	Nomascus leucogenys	99.74	0.00e+00	643.00
IUUC-Opr-070536	Ochotona princeps	77.98	3.00e-131	461.00
IUUC-Ont-072656	Oreochromis niloticus	70.22	1.00e-106	379.00
IUUC-Ocu-074169	Oryctolagus cuniculus	93.78	0.00e+00	648.00
IUUC-Obr-076491	Oryza brachyantha	35.90	5.00e-10	58.20
IUUC-Ogu-078925	Oryza glumaepatula	37.88	3.00e-09	55.80
IUUC-Olo-080407	Oryza longistaminata	38.10	3.00e-10	57.00
IUUC-Ome-081252	Oryza meridionalis	35.90	8.00e-10	57.40
IUUC-Opu-083597	Oryza punctata	37.88	1.00e-09	56.60
IUUC-Oru-084860	Oryza rufipogon	37.88	2.00e-09	55.80
IUUC-Osa-085634	Oryza sativa	35.90	5.00e-10	58.20
IUUC-Ola-086356	Oryzias latipes	66.20	3.00e-100	358.00
IUUC-Olu-087713	Ostreococcus lucimarinus	43.86	2.00e-09	56.20
IUUC-Oga-088785	Otolemur garnettii	90.76	1.00e-127	448.00
IUUC-Oar-089431	Ovis aries	89.12	2.00e-163	568.00
IUUC-Ptr-090885	Pan troglodytes	99.74	0.00e+00	643.00
IUUC-Pan-092062	Papio anubis	91.69	0.00e+00	669.00
IUUC-Psi-093715	Pelodiscus sinensis	74.49	5.00e-149	520.00
IUUC-Pfo-097302	Poecilia formosa	66.55	1.00e-107	383.00
IUUC-Pab-097767	Pongo abelii	100.00	0.00e+00	647.00
IUUC-Pva-102171	Pteropus vampyrus	92.76	4.00e-167	580.00
IUUC-Rno-106010	Rattus norvegicus	90.16	5.00e-162	563.00
IUUC-Sha-106704	Sarcophilus harrisii	87.72	3.00e-180	624.00
IUUC-Sar-113178	Sorex araneus	73.13	1.00e-72	266.00
IUUC-Ssc-115455	Sus scrofa	94.30	0.00e+00	635.00
IUUC-Tgu-116933	Taeniopygia guttata	83.33	1.00e-133	469.00
IUUC-Tru-118477	Takifugu rubripes	69.85	1.00e-105	376.00
IUUC-Tni-120144	Tetraodon nigroviridis	70.90	8.00e-103	366.00
IUUC-Tbe-127850	Tupaia belangeri	93.01	6.00e-165	573.00
IUUC-Ttr-128599	Tursiops truncatus	93.38	1.00e-136	479.00
IUUC-Xtr-131961	Xenopus tropicalis	69.21	1.00e-134	473.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence