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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045707
UUCD1 version UUC-HoS-00303
Ensembl Protein ID ENSP00000320508.5
UniProt Accession Q96GF1; A8K5C1; A9X3T8; Q8N900; RN185_HUMAN
Genbank Protein ID ABB97506.1; ABB97508.1; ABB97509.1; ABB97512.1; CAG30235.1; BAC04659.1; BAF83925.1; EAW59947.1; EAW59949.1; AAH09504.1; AAH26040.1; AAH33166.1; AAH12817.1; AAH35684.1
Protein Name E3 ubiquitin-protein ligase RNF185; RING finger protein 185; RING-type E3 ubiquitin transferase RNF185
Genbank Nucleotide ID DQ296559; DQ296561; DQ296562; DQ296565; CR456349; AK095947; AK291236; AC002073; CH471095; BC009504; BC026040; BC033166; BC012817; BC035684
Gene Name RNF185
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000138942.15 ENST00000326132.10 ENSP00000320508.5
ENSG00000138942.15 ENST00000266252.8 ENSP00000266252.7
ENSG00000138942.15 ENST00000426256.6 ENSP00000410916.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20009572
Classification
Family E-value Score Start End
E3 activity/RING/RING 5.70e-07 31.6 39 80
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iCl+  kd  ++  CgH+f+  Cl++w        +++ CP+C+
   Q: 39   CNICLDTAKD-AVISLCGHLFCWPCLHQW---LETRPNRQVCPVCK 80
           99********.77788*************...666999999****7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.
 E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.
Protein Sequence
(Fasta)
MASKGPSASA SPENSSAGGP SGSSNGAGES GGQDSTFECN ICLDTAKDAV ISLCGHLFCW 60
PCLHQWLETR PNRQVCPVCK AGISRDKVIP LYGRGSTGQQ DPREKTPPRP QGQRPEPENR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045707|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGTGACTGGA GTCCGCGTAG GAGGGGTCGG AGGTCTTACC CAACAGATTG ACGCGGCGTT 60
AGTATTGGCC GTGTACCCGA AAAACTGATT GACTGGGCTG GCGTTAACTG TGCGGAGGCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045707|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0044322--C:endoplasmic reticulum quality control compartment
GO:0016021--C:integral component of membrane
GO:0005741--C:mitochondrial outer membrane
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0044390--F:ubiquitin-like protein conjugating enzyme binding
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:1904380--P:endoplasmic reticulum mannose trimming
GO:0071712--P:ER-associated misfolded protein catabolic process
GO:0036503--P:ERAD pathway
GO:0051865--P:protein autoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0055085--P:transmembrane transport
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG hsa:91445
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001042 Aegilops tauschii 51.61 3.00e-24 105.00
IUUC-Aml-001875 Ailuropoda melanoleuca 100.00 2.00e-62 231.00
IUUC-Atr-002721 Amborella trichopoda 54.35 3.00e-25 108.00
IUUC-Apl-003744 Anas platyrhynchos 100.00 4.00e-40 155.00
IUUC-Aly-006065 Arabidopsis lyrata 56.98 9.00e-26 110.00
IUUC-Ath-007401 Arabidopsis thaliana 54.55 1.00e-24 106.00
IUUC-Ame-011667 Astyanax mexicanus 96.79 7.00e-53 199.00
IUUC-Bgr-012018 Blumeria graminis 40.98 2.00e-09 56.20
IUUC-Bta-012734 Bos taurus 100.00 4.00e-62 230.00
IUUC-Bci-013671 Botrytis cinerea 48.98 1.00e-09 57.40
IUUC-Cel-018228 Caenorhabditis elegans 70.59 2.00e-34 139.00
IUUC-Cja-019136 Callithrix jacchus 99.38 6.00e-62 229.00
IUUC-Cfa-020308 Canis familiaris 100.00 2.00e-62 231.00
IUUC-Cpo-021347 Cavia porcellus 98.75 1.00e-61 228.00
IUUC-Cre-022829 Chlamydomonas reinhardtii 56.32 3.00e-26 109.00
IUUC-Csa-023755 Chlorocebus sabaeus 99.48 3.00e-67 247.00
IUUC-Dre-028094 Danio rerio 96.86 2.00e-59 221.00
IUUC-Dno-029402 Dasypus novemcinctus 100.00 2.00e-62 231.00
IUUC-Dor-030373 Dipodomys ordii 100.00 2.00e-62 231.00
IUUC-Dme-031966 Drosophila melanogaster 60.98 6.00e-56 211.00
IUUC-Ete-032786 Echinops telfairi 98.44 2.00e-64 238.00
IUUC-Eca-034261 Equus caballus 100.00 2.00e-62 231.00
IUUC-Eeu-034614 Erinaceus europaeus 90.00 1.00e-49 188.00
IUUC-Fca-036049 Felis catus 100.00 2.00e-62 231.00
IUUC-Fal-037085 Ficedula albicollis 98.76 8.00e-62 229.00
IUUC-Gmo-039369 Gadus morhua 94.51 2.00e-55 208.00
IUUC-Gga-040514 Gallus gallus 99.38 1.00e-61 229.00
IUUC-Gac-041719 Gasterosteus aculeatus 95.73 1.00e-56 212.00
IUUC-Gma-043248 Glycine max 59.30 6.00e-27 114.00
IUUC-Ggo-044504 Gorilla gorilla 100.00 2.00e-62 231.00
IUUC-Hvu-047487 Hordeum vulgare 52.75 7.00e-24 103.00
IUUC-Itr-048343 Ictidomys tridecemlineatus 98.44 1.00e-63 235.00
IUUC-Lch-050658 Latimeria chalumnae 93.12 2.00e-59 221.00
IUUC-Loc-052118 Lepisosteus oculatus 96.95 2.00e-57 214.00
IUUC-Laf-054438 Loxodonta africana 99.48 9.00e-65 239.00
IUUC-Mcc-054641 Macaca mulatta 96.35 6.00e-60 223.00
IUUC-Meu-056828 Macropus eugenii 81.55 4.00e-35 139.00
IUUC-Mor-057077 Magnaporthe oryzae 37.29 2.00e-08 54.30
IUUC-Mpo-057431 Magnaporthe poae 35.29 5.00e-09 55.80
IUUC-Mtr-058107 Medicago truncatula 59.30 2.00e-26 112.00
IUUC-Mga-059554 Meleagris gallopavo 99.38 1.00e-61 229.00
IUUC-Mvi-060316 Microbotryum violaceum 50.88 8.00e-12 63.90
IUUC-Mmr-061662 Microcebus murinus 93.87 2.00e-53 201.00
IUUC-Mdo-062774 Monodelphis domestica 100.00 2.00e-62 231.00
IUUC-Mmu-063372 Mus musculus 98.44 4.00e-66 244.00
IUUC-Mpu-066033 Mustela putorius furo 100.00 1.00e-62 235.00
IUUC-Mlu-067254 Myotis lucifugus 100.00 2.00e-62 231.00
IUUC-Ncr-068628 Neurospora crassa 43.14 5.00e-10 58.90
IUUC-Nle-069850 Nomascus leucogenys 100.00 2.00e-62 231.00
IUUC-Opr-070197 Ochotona princeps 88.12 6.00e-58 216.00
IUUC-Ont-071950 Oreochromis niloticus 97.45 2.00e-58 218.00
IUUC-Oan-073480 Ornithorhynchus anatinus 100.00 2.00e-62 231.00
IUUC-Ocu-073878 Oryctolagus cuniculus 91.88 2.00e-62 231.00
IUUC-Oba-075248 Oryza barthii 55.84 2.00e-23 102.00
IUUC-Ola-086800 Oryzias latipes 97.50 2.00e-55 208.00
IUUC-Oga-088197 Otolemur garnettii 100.00 5.00e-65 240.00
IUUC-Ptr-091106 Pan troglodytes 100.00 2.00e-62 231.00
IUUC-Pan-092671 Papio anubis 99.48 3.00e-67 247.00
IUUC-Psi-093323 Pelodiscus sinensis 100.00 4.00e-62 230.00
IUUC-Pno-094942 Phaeosphaeria nodorum 42.68 3.00e-10 59.30
IUUC-Ppa-095474 Physcomitrella patens 55.91 3.00e-26 112.00
IUUC-Pfo-096943 Poecilia formosa 96.25 8.00e-55 206.00
IUUC-Pab-097845 Pongo abelii 100.00 2.00e-62 231.00
IUUC-Ppe-102011 Prunus persica 58.14 3.00e-26 111.00
IUUC-Pva-102298 Pteropus vampyrus 100.00 2.00e-62 231.00
IUUC-Pyt-104640 Pyrenophora triticirepentis 37.50 6.00e-10 58.20
IUUC-Rno-105293 Rattus norvegicus 98.96 9.00e-67 246.00
IUUC-Sha-107361 Sarcophilus harrisii 95.83 5.00e-66 243.00
IUUC-Smo-109663 Selaginella moellendorffii 51.69 2.00e-23 100.00
IUUC-Sit-110376 Setaria italica 55.81 1.00e-24 106.00
IUUC-Stu-112801 Solanum tuberosum 54.65 4.00e-24 105.00
IUUC-Sar-113669 Sorex araneus 100.00 8.00e-26 108.00
IUUC-Ssc-116228 Sus scrofa 100.00 2.00e-62 231.00
IUUC-Tgu-116886 Taeniopygia guttata 98.76 8.00e-62 229.00
IUUC-Tni-120909 Tetraodon nigroviridis 93.90 1.00e-56 212.00
IUUC-Tae-123670 Triticum aestivum 52.94 4.00e-23 101.00
IUUC-Tur-126676 Triticum urartu 52.94 3.00e-23 101.00
IUUC-Tbe-127360 Tupaia belangeri 100.00 3.00e-43 167.00
IUUC-Ttr-129044 Tursiops truncatus 100.00 2.00e-62 231.00
IUUC-Vda-129983 Verticillium dahliae 43.75 1.00e-08 53.10
IUUC-Vpa-130365 Vicugna pacos 99.38 2.00e-61 228.00
IUUC-Vvi-131449 Vitis vinifera 56.32 2.00e-26 112.00
IUUC-Xtr-131916 Xenopus tropicalis 94.57 2.00e-42 164.00
IUUC-Xma-133333 Xiphophorus maculatus 93.90 3.00e-55 207.00
Created Date 25-Jun-2017

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