iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053808

UUCD1 version

UUC-LoA-01111

Ensembl Protein ID

ENSLAFP00000023507.1

UniProt Accession

G3U6P9; G3U6P9_LOXAF

Protein Name

Uncharacterized protein

Gene Name

USP28

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000017565.3	ENSLAFT00000033609.1	ENSLAFP00000023507.1
ENSLAFG00000017565.3	ENSLAFT00000017569.3	ENSLAFP00000014736.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.90e-59	201.9	143	632

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeef 84
           +GlkN+gNtC++N+v+Q+L+++pe+r+l+l+     +  e+++    ++++  ++++lq lf+ ++ s++k v+p++ l+ lk + ++ 
   Q: 143  VGLKNVGNTCWFNAVIQSLFQLPEFRRLVLSyslpqNVLENCRSH-TEKRNIVFMQELQYLFALMMGSNRKFVDPSAALDLLKGAFRS- 229
           6******************************97665555555543.478888*******************************99987. PP
   S: 85   sgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldls 173
           s+ +qqD++Ef++ lld le+++                 +   + +++  +k ++++++lF g++ ++ + +     +   e+f +++
   Q: 230  SEEQQQDVSEFTHKLLDWLEDAF-----------------QPAVNVNSNSSNKCENPMVQLFYGTFLTEGVREGKPFCN--SETFGQYP 299
           99*********************.................233445577899***************999987666655..899***** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
           l+v+g +     +l++cLe  + e  +e    +  +   ++++  ++++++klP+vL+++L+Rf+f+++ +++eki++k+efp+ + ++
   Q: 300  LQVNGYR-----NLDECLEGAMVEGDVE----LLPSD--HSVKYGQECWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQIIYID 377
           *******.....99****7665555555....55544..5677899******************************************* PP
   S: 263  pfcts.................................................................................... 267
           +++ +                                                                                    
   Q: 378  RYMYRskelirskrecirklkeeikvlqqkleryvkygsgparfplpdmlkyviefastkpasesspspsdtrvtlplssvhcpvsdlt 466
           *9999788888888888888888888888888888888888888888888888888777777777777777777777777777776666 PP
   S: 268  .......peekqke........................................................................... 274
                  +     +                                                                           
   Q: 467  skeststE-----Sssqevestfsspedslhksesepltssrsamempthpaprtvtdeeinfvktclqrwrseieqdiqdlknciass 550
           66655550.....0455556666666666667777777778888888888888888888888888888888888888899999999999 PP
   S: 275  ..............kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                         ++ Y+L+av+vH+G+++ GHY+ay++n+ ++ Wl+++D +Vte+++ee ++++       +aY+l+Y 
   Q: 551  tqtieqmycdpllrQVPYRLHAVLVHEGQANAGHYWAYIYNQPRQtWLKYNDISVTESSWEELERDSYgglrnVSAYCLMYI 632
           99999999*****9***************************88888*******************8879************6 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

SCQMLLNQLR EVTGIQDPSF LHEALKASNG DITQAVSLLT DERVKEPSQD SVATEPSEVE 60
DSAANKEVLA KVIDLTHDNK DDLQAAIALS LLESPKIQAD GRDLNRMHEA TSAETKRSKR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTGCCAAA TGCTGTTAAA TCAACTGAGA GAAGTCACAG GCATTCAGGA CCCTTCCTTT 60
CTTCATGAAG CTTTGAAGGT TGGTTTCAAG AGCCCAATTA CTCAACACGC TTCAGGATAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0016604--C:nuclear body
GO:0043234--C:protein complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008283--P:cell proliferation
GO:0034644--P:cellular response to UV
GO:0000077--P:DNA damage checkpoint
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0016579--P:protein deubiquitination
GO:0007265--P:Ras protein signal transduction
GO:0031647--P:regulation of protein stability
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001836	Ailuropoda melanoleuca	86.95	0.00e+00	1810.00
IUUC-Apl-004010	Anas platyrhynchos	64.21	0.00e+00	1312.00
IUUC-Aca-004741	Anolis carolinensis	59.88	0.00e+00	799.00
IUUC-Ate-010275	Aspergillus terreus	35.19	4.00e-11	63.90
IUUC-Bta-013377	Bos taurus	85.82	0.00e+00	1720.00
IUUC-Cja-019977	Callithrix jacchus	88.98	0.00e+00	1808.00
IUUC-Cfa-020378	Canis familiaris	90.42	0.00e+00	1260.00
IUUC-Cpo-021817	Cavia porcellus	83.47	0.00e+00	1741.00
IUUC-Csa-023446	Chlorocebus sabaeus	80.86	0.00e+00	1274.00
IUUC-Cho-024717	Choloepus hoffmanni	75.87	0.00e+00	1048.00
IUUC-Cme-027167	Cyanidioschyzon merolae	31.60	2.00e-15	78.20
IUUC-Dre-028105	Danio rerio	56.43	0.00e+00	689.00
IUUC-Dno-029559	Dasypus novemcinctus	89.51	0.00e+00	1425.00
IUUC-Dor-030955	Dipodomys ordii	84.27	0.00e+00	1712.00
IUUC-Ete-032828	Echinops telfairi	74.97	0.00e+00	1036.00
IUUC-Eca-034300	Equus caballus	87.49	0.00e+00	1752.00
IUUC-Eeu-034458	Erinaceus europaeus	82.79	0.00e+00	1526.00
IUUC-Fca-035753	Felis catus	87.14	0.00e+00	1807.00
IUUC-Fal-037062	Ficedula albicollis	62.31	0.00e+00	805.00
IUUC-Gga-040878	Gallus gallus	64.03	0.00e+00	1248.00
IUUC-Gac-041867	Gasterosteus aculeatus	51.71	0.00e+00	1030.00
IUUC-Ggo-045384	Gorilla gorilla	88.89	0.00e+00	1807.00
IUUC-Hsa-046277	Homo sapiens	88.89	0.00e+00	1801.00
IUUC-Itr-048276	Ictidomys tridecemlineatus	86.11	0.00e+00	1057.00
IUUC-Lch-049692	Latimeria chalumnae	61.50	0.00e+00	1259.00
IUUC-Loc-052636	Lepisosteus oculatus	60.66	0.00e+00	808.00
IUUC-Mcc-055473	Macaca mulatta	80.86	0.00e+00	1275.00
IUUC-Meu-056416	Macropus eugenii	68.67	0.00e+00	1353.00
IUUC-Mla-058944	Melampsora laricipopulina	22.72	6.00e-09	57.00
IUUC-Mga-060011	Meleagris gallopavo	61.44	0.00e+00	1247.00
IUUC-Mmr-060720	Microcebus murinus	85.38	0.00e+00	1709.00
IUUC-Mdo-061955	Monodelphis domestica	81.53	0.00e+00	1180.00
IUUC-Mmu-063870	Mus musculus	86.36	0.00e+00	1756.00
IUUC-Mpu-066454	Mustela putorius furo	90.59	0.00e+00	1245.00
IUUC-Mlu-067487	Myotis lucifugus	82.27	0.00e+00	1686.00
IUUC-Nle-070044	Nomascus leucogenys	88.90	0.00e+00	1810.00
IUUC-Opr-070888	Ochotona princeps	96.75	1.00e-158	554.00
IUUC-Ocu-074523	Oryctolagus cuniculus	85.07	0.00e+00	1722.00
IUUC-Ola-086393	Oryzias latipes	52.53	0.00e+00	1039.00
IUUC-Oga-088618	Otolemur garnettii	86.55	0.00e+00	1752.00
IUUC-Oar-089848	Ovis aries	85.60	0.00e+00	1197.00
IUUC-Ptr-091630	Pan troglodytes	86.47	0.00e+00	1319.00
IUUC-Pan-092882	Papio anubis	90.49	0.00e+00	738.00
IUUC-Psi-093422	Pelodiscus sinensis	67.40	0.00e+00	964.00
IUUC-Pma-094250	Petromyzon marinus	50.65	5.00e-61	227.00
IUUC-Pfo-096466	Poecilia formosa	53.19	0.00e+00	741.00
IUUC-Pab-098337	Pongo abelii	88.98	0.00e+00	1804.00
IUUC-Pca-100901	Procavia capensis	72.53	0.00e+00	1414.00
IUUC-Pva-102226	Pteropus vampyrus	81.39	0.00e+00	1540.00
IUUC-Rno-105735	Rattus norvegicus	83.91	0.00e+00	1209.00
IUUC-Sha-107489	Sarcophilus harrisii	80.02	0.00e+00	1685.00
IUUC-Ssl-108532	Sclerotinia sclerotiorum	34.57	6.00e-09	57.00
IUUC-Tgu-116609	Taeniopygia guttata	63.38	0.00e+00	1238.00
IUUC-Tru-117807	Takifugu rubripes	52.19	0.00e+00	999.00
IUUC-Tsy-118971	Tarsius syrichta	78.93	0.00e+00	1070.00
IUUC-Tni-119983	Tetraodon nigroviridis	51.91	0.00e+00	1018.00
IUUC-Ttr-128887	Tursiops truncatus	81.30	0.00e+00	1608.00
IUUC-Vpa-130614	Vicugna pacos	83.85	0.00e+00	1306.00
IUUC-Xtr-132436	Xenopus tropicalis	58.26	0.00e+00	1154.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence