iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089848

Ensembl Protein ID

ENSOARP00000019902.1

UniProt Accession

W5QB07; W5QB07_SHEEP

Genbank Protein ID

ENSOARP00000019902

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01031312

Gene Name

USP28

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000018532.1	ENSOART00000020177.1	ENSOARP00000019902.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-57	195.9	139	630

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeef 84
           +GlkN+gNtC++ +v+Q+L+++pe+r+l+l+     +  e+++    ++++  ++++lq lf+ ++ s++k v+p++ l+ lk + ++ 
   Q: 139  VGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSyslpqNVLENCPSH-TEKRNIVFMQELQYLFALMMGSNRKFVDPSAALDLLKGAFRS- 225
           6******************************96555445555543.3678889******************************99987. PP
   S: 85   sgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldls 173
            + +qqD++Ef++ lld le++++                     + +++ +k+++++++lF g++ ++ + +        +e+f +++
   Q: 226  PEEQQQDVSEFTHKLLDWLEDAFQL------------------AVNVNNPRNKSENPMVQLFYGTFLTEGIREGKPF--CNNETFGQYP 294
           799********************22..................23457899****************9888765555..45899***** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
           l+v+g +     +l++cLe  + e  +e    +  +   ++++  ++ +++klP+vL+++L+Rf+f+++ +++eki++k+efp+ + ++
   Q: 295  LQVNGYR-----NLDECLEGAMVEGDIE----LLPSD--HSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQIIYMD 372
           *******.....99****7766666665....55544..456778899***************************************** PP
   S: 263  pfcts.................................................................................... 267
           +++ +                                                                                    
   Q: 373  RYMYRskelvrskrecirklkeeikilqrkleryvkygsgparfplpdmlkyviefastkpasessasqsgaciteplssahsltsdlt 461
           *9999778888888777777777777777777777777777777777777777777777777776666666666666666666666666 PP
   S: 268  ......peekqke............................................................................ 274
                 +     e                                                                            
   Q: 462  skestsK-----Estsqeaegtfsssedsvhkskmaeqpltpprssvempahpaprtvtdeeinfvktclqrwrneieqdiqadlkngi 545
           6555540.....15555666777777777777778888888888888888888888888888888999999999999999999999999 PP
   S: 275  .................kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                            ++ Y+L+av+vH+G+++ GHY+ayv+n+ ++ Wl+++D +Vte+++ee ++++       +aY+l+Y 
   Q: 546  asttqtieqmycdpllrQVPYRLHAVLVHEGQANAGHYWAYVYNQPRQvWLKYNDISVTESSWEELERDSYggqrnVSAYCLMYI 630
           999999999*******9***************************99999*******************8879***9********6 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MLLNQLREIT GIQDPSFLHE ALKASNGDIT QAVSLLTDER VKEPSQETAA EPSEEEGSAA 60
SKEELAKVID LTRDSKDDLQ AAIALSLLES PKVQADGRDL NRMHEVTCAE TKRSKRKRCE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTGTTAA ATCAACTGAG AGAAATCACT GGCATTCAGG ACCCTTCTTT TCTTCATGAA 60
GCTCTGAAGG TTAGTTTCAA GGCCTCTATG AGTCAACAGG TTTTAGACAG TTGTTCATAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR011990--TPR-like_helical_dom
IPR009060--UBA-like
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001836	Ailuropoda melanoleuca	91.90	0.00e+00	1371.00
IUUC-Apl-004010	Anas platyrhynchos	64.09	0.00e+00	1396.00
IUUC-Aca-004741	Anolis carolinensis	61.65	0.00e+00	1338.00
IUUC-Ang-009577	Aspergillus niger	37.61	2.00e-12	68.60
IUUC-Ame-011910	Astyanax mexicanus	43.60	2.00e-179	624.00
IUUC-Bta-013377	Bos taurus	97.47	0.00e+00	1369.00
IUUC-Cja-019977	Callithrix jacchus	90.57	0.00e+00	1324.00
IUUC-Cfa-020378	Canis familiaris	92.79	0.00e+00	2050.00
IUUC-Cpo-021817	Cavia porcellus	85.01	0.00e+00	1262.00
IUUC-Csa-023446	Chlorocebus sabaeus	93.32	0.00e+00	2075.00
IUUC-Cho-024717	Choloepus hoffmanni	79.07	0.00e+00	652.00
IUUC-Csv-025911	Ciona savignyi	40.91	2.00e-100	360.00
IUUC-Dor-030955	Dipodomys ordii	85.13	0.00e+00	1266.00
IUUC-Ete-032828	Echinops telfairi	82.79	0.00e+00	777.00
IUUC-Eca-034300	Equus caballus	90.97	0.00e+00	1289.00
IUUC-Eeu-034458	Erinaceus europaeus	87.52	0.00e+00	1259.00
IUUC-Fca-035753	Felis catus	90.70	0.00e+00	1364.00
IUUC-Fal-037062	Ficedula albicollis	67.17	0.00e+00	1422.00
IUUC-Gac-041867	Gasterosteus aculeatus	54.33	0.00e+00	1141.00
IUUC-Ggo-045384	Gorilla gorilla	90.31	0.00e+00	1315.00
IUUC-Hsa-046277	Homo sapiens	90.56	0.00e+00	1321.00
IUUC-Itr-048276	Ictidomys tridecemlineatus	65.44	8.00e-175	607.00
IUUC-Loc-052636	Lepisosteus oculatus	62.97	0.00e+00	1360.00
IUUC-Laf-053808	Loxodonta africana	73.43	0.00e+00	1238.00
IUUC-Mcc-055473	Macaca mulatta	93.32	0.00e+00	2074.00
IUUC-Meu-056416	Macropus eugenii	68.39	0.00e+00	976.00
IUUC-Mga-060011	Meleagris gallopavo	62.80	0.00e+00	1318.00
IUUC-Mmr-060720	Microcebus murinus	87.00	0.00e+00	1231.00
IUUC-Mdo-061955	Monodelphis domestica	84.16	0.00e+00	1816.00
IUUC-Mmu-063870	Mus musculus	84.99	0.00e+00	1263.00
IUUC-Mpu-066454	Mustela putorius furo	92.43	0.00e+00	1962.00
IUUC-Mlu-067487	Myotis lucifugus	83.02	0.00e+00	1210.00
IUUC-Nle-070044	Nomascus leucogenys	90.82	0.00e+00	1327.00
IUUC-Opr-070888	Ochotona princeps	97.47	3.00e-161	562.00
IUUC-Ocu-074523	Oryctolagus cuniculus	87.12	0.00e+00	1278.00
IUUC-Ola-086393	Oryzias latipes	52.05	0.00e+00	1101.00
IUUC-Oga-088618	Otolemur garnettii	88.30	0.00e+00	1289.00
IUUC-Ptr-091630	Pan troglodytes	89.06	0.00e+00	872.00
IUUC-Pan-092882	Papio anubis	92.88	0.00e+00	1551.00
IUUC-Psi-093422	Pelodiscus sinensis	72.63	0.00e+00	1606.00
IUUC-Pma-094250	Petromyzon marinus	51.54	7.00e-80	290.00
IUUC-Pab-098337	Pongo abelii	90.82	0.00e+00	1327.00
IUUC-Pca-100901	Procavia capensis	67.60	0.00e+00	923.00
IUUC-Pva-102226	Pteropus vampyrus	83.36	0.00e+00	1097.00
IUUC-Rno-105735	Rattus norvegicus	88.43	0.00e+00	1986.00
IUUC-Sha-107489	Sarcophilus harrisii	77.69	0.00e+00	1715.00
IUUC-Sar-112977	Sorex araneus	75.00	0.00e+00	807.00
IUUC-Ssc-115463	Sus scrofa	92.28	0.00e+00	1134.00
IUUC-Tsy-118971	Tarsius syrichta	96.24	0.00e+00	636.00
IUUC-Ttr-128887	Tursiops truncatus	85.52	0.00e+00	1188.00
IUUC-Uma-129338	Ustilago maydis	25.67	5.00e-13	70.90
IUUC-Vpa-130614	Vicugna pacos	81.89	0.00e+00	1380.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence