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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063125
UUCD1 version UUC-MuM-00786
Ensembl Protein ID ENSMUSP00000133175.2
UniProt Accession Q8R2P1; KLH25_MOUSE
Genbank Protein ID BAE25266.1; AAH27373.1
Protein Name Kelch-like protein 25; Ectoderm-neural cortex protein 2
Genbank Nucleotide ID AK143086; BC027373
Gene Name Klhl25; Enc2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000055652.14 ENSMUST00000171155.3 ENSMUSP00000133175.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 9.90e-20 71.8 46 114
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 3.20e-09 36.0 146 177
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd.vqpevfrallkFlYtgkldene 69
           +Dv+l  g++ f++h++vLaasS++F+a+f+++l+es+  ++v+++d + pev++ ll+F Y++++ +ne
   Q: 46   TDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESR-DDTVNFQDnLHPEVLELLLDFAYSSRIVINE 114
           7*************************************.*******99*****************99886 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           ++Nclg++ ++d+++c++L+++  ++ l hF+
   Q: 146  PSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFE 177
           89****************************95 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.
 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.
Protein Sequence
(Fasta)
MSVSVHETRK SRSSTGSMNI SVFHKASHPD CVLAHLNTLR KHCMFTDVTL WAGDRAFPCH 60
RAVLAASSRY FEAMFSHGLR ESRDDTVNFQ DNLHPEVLEL LLDFAYSSRI VINEENAESL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063125|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGATTGGTTG CTGCGCTTCG GGCCGCGAGG CGGGGCGGGA AGGCCGGAGA AACTAGTTTG 60
TTGGCAGCGC CCGTGCGGTT CGGCTACGGG ATCGCGGCCG GGACTGGTGA GCCGGCCGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063125|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat
KW-0810--Translation regulation
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030565--KLHL25
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006446--P:regulation of translational initiation
KEGG mmu:207952
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002373 Ailuropoda melanoleuca 95.25 0.00e+00 1178.00
IUUC-Apl-003543 Anas platyrhynchos 88.31 0.00e+00 1068.00
IUUC-Aca-004729 Anolis carolinensis 86.25 0.00e+00 1056.00
IUUC-Ame-011020 Astyanax mexicanus 83.70 0.00e+00 1016.00
IUUC-Bta-012955 Bos taurus 93.21 0.00e+00 1159.00
IUUC-Cja-018839 Callithrix jacchus 94.40 0.00e+00 1167.00
IUUC-Cfa-020224 Canis familiaris 95.59 0.00e+00 1178.00
IUUC-Cpo-021593 Cavia porcellus 91.51 0.00e+00 1098.00
IUUC-Csa-023276 Chlorocebus sabaeus 95.08 0.00e+00 1174.00
IUUC-Dre-028053 Danio rerio 83.70 0.00e+00 991.00
IUUC-Dno-029287 Dasypus novemcinctus 92.02 0.00e+00 1143.00
IUUC-Dor-030908 Dipodomys ordii 86.08 0.00e+00 1042.00
IUUC-Fca-035897 Felis catus 95.25 0.00e+00 1177.00
IUUC-Fal-037036 Ficedula albicollis 88.46 0.00e+00 1074.00
IUUC-Gmo-039345 Gadus morhua 83.19 0.00e+00 981.00
IUUC-Gga-040404 Gallus gallus 88.29 0.00e+00 1075.00
IUUC-Gac-042447 Gasterosteus aculeatus 83.02 0.00e+00 998.00
IUUC-Ggo-045060 Gorilla gorilla 94.91 0.00e+00 1172.00
IUUC-Hsa-046494 Homo sapiens 94.91 0.00e+00 1172.00
IUUC-Itr-047993 Ictidomys tridecemlineatus 95.76 0.00e+00 1179.00
IUUC-Lch-050211 Latimeria chalumnae 85.54 0.00e+00 1032.00
IUUC-Loc-052578 Lepisosteus oculatus 83.53 0.00e+00 1021.00
IUUC-Laf-053498 Loxodonta africana 93.72 0.00e+00 1113.00
IUUC-Mcc-055033 Macaca mulatta 94.91 0.00e+00 1172.00
IUUC-Meu-056893 Macropus eugenii 90.15 0.00e+00 1119.00
IUUC-Mga-060025 Meleagris gallopavo 88.46 0.00e+00 1075.00
IUUC-Mmr-060658 Microcebus murinus 94.06 0.00e+00 1169.00
IUUC-Mdo-062667 Monodelphis domestica 89.98 0.00e+00 1114.00
IUUC-Mpu-066209 Mustela putorius furo 95.42 0.00e+00 1180.00
IUUC-Mlu-068237 Myotis lucifugus 91.17 0.00e+00 1108.00
IUUC-Nle-069454 Nomascus leucogenys 94.85 0.00e+00 1159.00
IUUC-Ont-072138 Oreochromis niloticus 83.19 0.00e+00 984.00
IUUC-Oan-073320 Ornithorhynchus anatinus 83.87 0.00e+00 1049.00
IUUC-Ocu-073765 Oryctolagus cuniculus 87.27 0.00e+00 1065.00
IUUC-Oga-088002 Otolemur garnettii 94.40 0.00e+00 1162.00
IUUC-Oar-089481 Ovis aries 92.53 0.00e+00 1153.00
IUUC-Ptr-091200 Pan troglodytes 95.08 0.00e+00 1177.00
IUUC-Psi-093884 Pelodiscus sinensis 87.95 0.00e+00 1063.00
IUUC-Pno-095143 Phaeosphaeria nodorum 28.51 4.00e-15 75.50
IUUC-Pva-102321 Pteropus vampyrus 93.72 0.00e+00 1160.00
IUUC-Rno-104835 Rattus norvegicus 99.15 0.00e+00 1192.00
IUUC-Sha-107528 Sarcophilus harrisii 89.98 0.00e+00 1118.00
IUUC-Ssc-116161 Sus scrofa 95.25 0.00e+00 1174.00
IUUC-Tgu-116569 Taeniopygia guttata 88.29 0.00e+00 1071.00
IUUC-Tni-120525 Tetraodon nigroviridis 74.28 0.00e+00 857.00
IUUC-Ttr-129297 Tursiops truncatus 94.57 0.00e+00 1169.00
Created Date 25-Jun-2017

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