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Tag Content
iUUCD ID IUUC-Eca-034066
Ensembl Protein ID ENSECAP00000009841.1
UniProt Accession F6VFA7; F6VFA7_HORSE
Protein Name Histone-lysine N-methyltransferase
Gene Name WHSC1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSECAG00000011661.1 ENSECAT00000012457.1 ENSECAP00000009841.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 1.70e-15 57.1 833 873
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC +gg+    l++Ce C  +fHp+Cl+++    +p+ + w+C++Cr
   Q: 833  WCFVCSKGGS----LLCCESCPAAFHPDCLNIE----MPDGS-WFCNDCR 873
           8*********....*******************....9***8.******8 PP
   
Organism Equus caballus
Protein Sequence
(Fasta)
MEFSIKKNPL SVQKVVKCIK MKQAPEILGN TNGKTQNCEV NRECSVFLSK AQLSTSLQEG 60
VMQKFNGHDA LPFIPTEKLK DLTSRVFNGE PGAHDARLRF ESQEMKGIGT PPNTTPIKNG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Eca-034066|E3,PHD|Equus caballus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTTTAATATT GTAGTGTTCT AAGAACGGAA GCATCTGGGC TGAATGGAAT TTAGCATCAA 60
AAAAAATCCT CTTTCTGTTC AGAAAGTTGT AAAGTGCATA AAGATGAAGC AGGCACCAGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Eca-034066|E3,PHD|Equus caballus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR006560--AWS_dom
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51215--AWS
PS50118--HMG_BOX_2
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS50089--ZF_RING_2
Pfam

PF00505--HMG_box
PF00855--PWWP
PF00856--SET
SMART

SM00570--AWS
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00184--RING
SM00317--SET
Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0043565--F:sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0003289--P:atrial septum primum morphogenesis
GO:0003290--P:atrial septum secundum morphogenesis
GO:0060348--P:bone development
GO:0010452--P:histone H3-K36 methylation
GO:0034770--P:histone H4-K20 methylation
GO:0003149--P:membranous septum morphogenesis
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048298--P:positive regulation of isotype switching to IgA isotypes
GO:2001032--P:regulation of double-strand break repair via nonhomologous end joining
GO:0070201--P:regulation of establishment of protein localization
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002181 Ailuropoda melanoleuca 94.72 0.00e+00 2506.00
IUUC-Apl-003677 Anas platyrhynchos 82.30 0.00e+00 2177.00
IUUC-Aca-004278 Anolis carolinensis 76.85 0.00e+00 1407.00
IUUC-Ame-011932 Astyanax mexicanus 70.94 0.00e+00 1033.00
IUUC-Bta-012522 Bos taurus 87.16 0.00e+00 2274.00
IUUC-Cja-018908 Callithrix jacchus 92.91 0.00e+00 2387.00
IUUC-Cfa-020894 Canis familiaris 93.76 0.00e+00 2557.00
IUUC-Cpo-021982 Cavia porcellus 89.55 0.00e+00 2391.00
IUUC-Csa-023807 Chlorocebus sabaeus 93.65 0.00e+00 2424.00
IUUC-Cho-024405 Choloepus hoffmanni 74.01 0.00e+00 744.00
IUUC-Csv-026298 Ciona savignyi 39.64 2.00e-58 219.00
IUUC-Cme-027319 Cyanidioschyzon merolae 31.25 8.60e-02 30.80
IUUC-Dre-027492 Danio rerio 71.78 0.00e+00 1070.00
IUUC-Dno-030020 Dasypus novemcinctus 87.74 0.00e+00 2059.00
IUUC-Dor-031103 Dipodomys ordii 84.47 0.00e+00 2172.00
IUUC-Ete-032488 Echinops telfairi 82.35 0.00e+00 2139.00
IUUC-Eeu-035199 Erinaceus europaeus 72.49 0.00e+00 771.00
IUUC-Fca-035434 Felis catus 88.32 0.00e+00 2036.00
IUUC-Fal-037113 Ficedula albicollis 80.45 0.00e+00 2185.00
IUUC-Gmo-039686 Gadus morhua 70.78 0.00e+00 1015.00
IUUC-Gga-040273 Gallus gallus 80.50 0.00e+00 2141.00
IUUC-Gac-042123 Gasterosteus aculeatus 50.49 0.00e+00 1246.00
IUUC-Ggo-044643 Gorilla gorilla 93.20 0.00e+00 2436.00
IUUC-Hsa-046380 Homo sapiens 93.41 0.00e+00 2412.00
IUUC-Itr-048658 Ictidomys tridecemlineatus 92.88 0.00e+00 1458.00
IUUC-Lch-050217 Latimeria chalumnae 66.94 0.00e+00 1757.00
IUUC-Loc-052766 Lepisosteus oculatus 58.78 0.00e+00 1282.00
IUUC-Laf-053780 Loxodonta africana 91.51 0.00e+00 2484.00
IUUC-Mcc-054928 Macaca mulatta 93.87 0.00e+00 2459.00
IUUC-Meu-056184 Macropus eugenii 77.36 0.00e+00 805.00
IUUC-Mga-059576 Meleagris gallopavo 81.25 0.00e+00 2147.00
IUUC-Mmr-061045 Microcebus murinus 93.48 0.00e+00 2509.00
IUUC-Mdo-062576 Monodelphis domestica 85.25 0.00e+00 2261.00
IUUC-Mmu-063640 Mus musculus 90.70 0.00e+00 2378.00
IUUC-Mac-065303 Musa acuminata 28.04 4.00e-11 63.20
IUUC-Mpu-066512 Mustela putorius furo 94.80 0.00e+00 2505.00
IUUC-Mlu-067280 Myotis lucifugus 79.94 0.00e+00 1099.00
IUUC-Nle-069896 Nomascus leucogenys 93.33 0.00e+00 2318.00
IUUC-Ont-072197 Oreochromis niloticus 73.59 0.00e+00 1040.00
IUUC-Oan-072724 Ornithorhynchus anatinus 80.87 0.00e+00 1396.00
IUUC-Ocu-074758 Oryctolagus cuniculus 88.68 0.00e+00 2331.00
IUUC-Ogu-078030 Oryza glumaepatula 28.43 3.00e-12 65.90
IUUC-Oin-079557 Oryza indica 26.74 1.00e-09 57.00
IUUC-Olo-080702 Oryza longistaminata 41.94 2.00e-45 177.00
IUUC-Opu-083371 Oryza punctata 42.31 8.00e-47 182.00
IUUC-Osa-085353 Oryza sativa 26.74 1.00e-09 57.00
IUUC-Oga-088702 Otolemur garnettii 92.26 0.00e+00 2139.00
IUUC-Oar-089736 Ovis aries 81.20 0.00e+00 1994.00
IUUC-Ptr-091055 Pan troglodytes 93.33 0.00e+00 2411.00
IUUC-Pan-092752 Papio anubis 96.58 0.00e+00 1441.00
IUUC-Psi-093620 Pelodiscus sinensis 82.57 0.00e+00 2192.00
IUUC-Pfo-097464 Poecilia formosa 50.71 0.00e+00 1217.00
IUUC-Pab-098051 Pongo abelii 93.26 0.00e+00 2439.00
IUUC-Pop-099927 Populus trichocarpa 28.96 1.00e-11 65.50
IUUC-Pca-100273 Procavia capensis 90.48 0.00e+00 2387.00
IUUC-Pva-102473 Pteropus vampyrus 79.70 0.00e+00 1973.00
IUUC-Rno-105056 Rattus norvegicus 90.56 0.00e+00 2384.00
IUUC-Sha-107494 Sarcophilus harrisii 85.84 0.00e+00 2241.00
IUUC-Sar-113310 Sorex araneus 92.28 0.00e+00 1894.00
IUUC-Sbi-114581 Sorghum bicolor 34.26 2.00e-09 56.20
IUUC-Ssc-116344 Sus scrofa 85.84 0.00e+00 2293.00
IUUC-Tgu-116786 Taeniopygia guttata 82.28 0.00e+00 2177.00
IUUC-Tru-117638 Takifugu rubripes 50.07 0.00e+00 1244.00
IUUC-Tsy-118937 Tarsius syrichta 95.64 0.00e+00 1561.00
IUUC-Tni-120452 Tetraodon nigroviridis 53.94 0.00e+00 1181.00
IUUC-Tae-125237 Triticum aestivum 29.45 2.00e-07 49.70
IUUC-Tbe-127291 Tupaia belangeri 88.18 0.00e+00 1556.00
IUUC-Ttr-129017 Tursiops truncatus 84.61 0.00e+00 1806.00
IUUC-Xtr-132673 Xenopus tropicalis 67.29 0.00e+00 1797.00
Created Date 25-Jun-2017

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