iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062536

UUCD1 version

UUC-MoD-00731

Ensembl Protein ID

ENSMODP00000003223.2

UniProt Accession

F7DI62; F7DI62_MONDO

Protein Name

E3 ubiquitin-protein ligase

Gene Name

WWP2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000002655.3	ENSMODT00000003291.2	ENSMODP00000003223.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-135	452.3	539	871

Active Site

Position(s)	Description	Evidence
840	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 539  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 626
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle++dpe+y+s+ +iken   ++ee+gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNkeeY+ l+++
   Q: 627  GFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKEN---NLEECGLELYFIQDMEILGKVTSHELKEGGESIRVTEENKEEYIMLLTD 712
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev ple+l++F+e+elel++cG++eid+ d++k+t y++ yt++s+ iqwFw+v++e+++e+r ++LqFv
   Q: 713  WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMADWQKNTIYRH-YTKNSRPIQWFWQVVKEMDNEKRIRLLQFV 800
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p++f+i k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLlyAieet+gF++
   Q: 801  TGTCRLPVGGFAELIgcngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQ 871
           *********************************************************************96 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MASASSSRAG VGLPFEKSQL TLKVVSAKPK VHSRQPRINS FVEVAVDGLP SETKKTGKRI 60
GSSELLWNEI IVLNVTAQSH LDLKVWSCHT LRNELLGTAS VNLSNVLKNN GGKMENTQLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCATCTG CTAGCTCCAG CAGGGCAGGA GTGGGCCTGC CTTTTGAGAA GTCTCAGCTT 60
ACTTTGAAAG GTGAGTGAAA CTCATTTTTA TTTTGCCAAA GGCCAGTGAG CTATAGCAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	91.08	0.00e+00	1557.00
IUUC-Apl-003912	Anas platyrhynchos	76.75	0.00e+00	1239.00
IUUC-Aca-004291	Anolis carolinensis	81.38	0.00e+00	1442.00
IUUC-Bta-013231	Bos taurus	90.71	0.00e+00	1535.00
IUUC-Cel-018299	Caenorhabditis elegans	67.01	0.00e+00	828.00
IUUC-Cja-019455	Callithrix jacchus	90.71	0.00e+00	1598.00
IUUC-Cfa-021017	Canis familiaris	92.09	0.00e+00	1566.00
IUUC-Cpo-021988	Cavia porcellus	90.71	0.00e+00	1580.00
IUUC-Csa-023549	Chlorocebus sabaeus	90.94	0.00e+00	1607.00
IUUC-Cin-025212	Ciona intestinalis	71.63	0.00e+00	868.00
IUUC-Csv-026256	Ciona savignyi	70.59	0.00e+00	861.00
IUUC-Dre-028513	Danio rerio	91.77	0.00e+00	1138.00
IUUC-Dno-028976	Dasypus novemcinctus	91.52	0.00e+00	1610.00
IUUC-Dor-030176	Dipodomys ordii	89.27	0.00e+00	1476.00
IUUC-Dme-032041	Drosophila melanogaster	67.71	0.00e+00	859.00
IUUC-Eca-033949	Equus caballus	91.97	0.00e+00	1587.00
IUUC-Eeu-034529	Erinaceus europaeus	83.78	0.00e+00	1306.00
IUUC-Fca-036236	Felis catus	91.28	0.00e+00	1592.00
IUUC-Fal-036948	Ficedula albicollis	79.89	0.00e+00	1350.00
IUUC-Gmo-038842	Gadus morhua	89.42	0.00e+00	1074.00
IUUC-Gga-040617	Gallus gallus	80.90	0.00e+00	1450.00
IUUC-Gac-041338	Gasterosteus aculeatus	69.96	0.00e+00	1262.00
IUUC-Ggo-045278	Gorilla gorilla	91.40	0.00e+00	1617.00
IUUC-Hsa-046148	Homo sapiens	91.28	0.00e+00	1616.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	96.83	0.00e+00	1104.00
IUUC-Lch-050663	Latimeria chalumnae	78.39	0.00e+00	1392.00
IUUC-Loc-052604	Lepisosteus oculatus	75.57	0.00e+00	1320.00
IUUC-Laf-053944	Loxodonta africana	88.23	0.00e+00	1583.00
IUUC-Mcc-055655	Macaca mulatta	90.83	0.00e+00	1608.00
IUUC-Meu-055953	Macropus eugenii	84.17	0.00e+00	1451.00
IUUC-Mga-060190	Meleagris gallopavo	81.42	0.00e+00	1447.00
IUUC-Mmr-060896	Microcebus murinus	91.58	0.00e+00	1573.00
IUUC-Mmu-064017	Mus musculus	90.94	0.00e+00	1587.00
IUUC-Mpu-066608	Mustela putorius furo	88.79	0.00e+00	1515.00
IUUC-Mlu-067623	Myotis lucifugus	88.66	0.00e+00	1526.00
IUUC-Nle-069496	Nomascus leucogenys	89.12	0.00e+00	1564.00
IUUC-Opr-071054	Ochotona princeps	81.18	0.00e+00	1377.00
IUUC-Ont-071279	Oreochromis niloticus	73.91	0.00e+00	1277.00
IUUC-Oan-073512	Ornithorhynchus anatinus	89.22	0.00e+00	1501.00
IUUC-Ocu-074271	Oryctolagus cuniculus	90.10	0.00e+00	1557.00
IUUC-Ola-087237	Oryzias latipes	68.10	0.00e+00	1224.00
IUUC-Oga-088164	Otolemur garnettii	91.51	0.00e+00	1607.00
IUUC-Oar-089698	Ovis aries	91.06	0.00e+00	1543.00
IUUC-Ptr-091306	Pan troglodytes	90.02	0.00e+00	1585.00
IUUC-Pan-092814	Papio anubis	87.07	0.00e+00	1517.00
IUUC-Pma-094279	Petromyzon marinus	71.73	0.00e+00	808.00
IUUC-Pfo-096709	Poecilia formosa	73.39	0.00e+00	1284.00
IUUC-Pab-098494	Pongo abelii	87.54	0.00e+00	1538.00
IUUC-Pca-100596	Procavia capensis	80.66	0.00e+00	1318.00
IUUC-Pva-103154	Pteropus vampyrus	86.71	0.00e+00	1481.00
IUUC-Rno-104954	Rattus norvegicus	88.93	0.00e+00	1345.00
IUUC-Sha-106781	Sarcophilus harrisii	96.67	0.00e+00	1746.00
IUUC-Ssc-116307	Sus scrofa	79.20	0.00e+00	1358.00
IUUC-Tgu-116530	Taeniopygia guttata	76.75	0.00e+00	1208.00
IUUC-Tru-118287	Takifugu rubripes	90.33	0.00e+00	1078.00
IUUC-Tsy-119097	Tarsius syrichta	78.54	0.00e+00	1153.00
IUUC-Tni-120801	Tetraodon nigroviridis	67.78	0.00e+00	1142.00
IUUC-Tbe-127793	Tupaia belangeri	79.82	0.00e+00	1375.00
IUUC-Ttr-128275	Tursiops truncatus	86.01	0.00e+00	1496.00
IUUC-Uma-129332	Ustilago maydis	45.78	6.00e-141	494.00
IUUC-Xtr-132866	Xenopus tropicalis	83.10	0.00e+00	1142.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence