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Tag Content
UUCD2 ID IUUC-Tgu-116530
UUCD1 version UUC-TaG-00447
Ensembl Protein ID ENSTGUP00000008415.1
UniProt Accession H0ZCV4; H0ZCV4_TAEGU
Genbank Protein ID ENSTGUP00000008415
Protein Name E3 ubiquitin-protein ligase
Genbank Nucleotide ID ABQF01035020
Gene Name WWP2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSTGUG00000008128.1 ENSTGUT00000008503.1 ENSTGUP00000008415.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 4.30e-136 453.5 473 805
Active Site
Position(s) Description Evidence
774 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 473  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 560
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle++dpe+y+s+ + ken   ++ee+gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNkeeY+ l+++
   Q: 561  GFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWTKEN---SLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD 646
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev+ple+l++F+e+elel++cG++eid++d++k+t y++ yt++s++iqwFw+v++e+++e+r ++LqFv
   Q: 647  WRFTRGVEEQTKAFLDGFNEVVPLEWLRYFDEKELELMLCGMQEIDMNDWQKNTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFV 734
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p++f+i k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLlyAieet+gF++
   Q: 735  TGTCRLPVGGFAELIgvngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQ 805
           *********************************************************************96 PP
   
Organism Taeniopygia guttata
Protein Sequence
(Fasta)
VENRQLTLDL QTENKGSVVS GGELTVFLDS PAVALGSVPD GTAATEGECP VEPGRSGPSP 60
ALLLPSSGSA PSLAGSAPSL AASFSPCSSP NAGSQVPGRD PPSTAVATEG RHQPPSTNCF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Tgu-116530|E3,HECT|Taeniopygia guttata
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGGAGAACA GGCAGCTGAC CCTGGACCTG CAGACGGAGA ACAAAGGCAG CGTTGTGTCT 60
GGCGGGGAGC TGACGGTGTT CCTGGACAGC CCGGCTGTTG CTCTGGGCAG CGTTCCCGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Tgu-116530|E3,HECT|Taeniopygia guttata
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00632--HECT
PF00397--WW
SMART

SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001575 Ailuropoda melanoleuca 75.92 0.00e+00 1179.00
IUUC-Apl-003912 Anas platyrhynchos 71.53 0.00e+00 1119.00
IUUC-Aca-004291 Anolis carolinensis 74.23 0.00e+00 1174.00
IUUC-Bta-013231 Bos taurus 76.08 0.00e+00 1167.00
IUUC-Cja-019455 Callithrix jacchus 75.46 0.00e+00 1201.00
IUUC-Cfa-021017 Canis familiaris 75.62 0.00e+00 1171.00
IUUC-Cpo-021988 Cavia porcellus 74.51 0.00e+00 1177.00
IUUC-Csa-023549 Chlorocebus sabaeus 75.86 0.00e+00 1210.00
IUUC-Dre-028513 Danio rerio 86.87 0.00e+00 1045.00
IUUC-Dno-028976 Dasypus novemcinctus 76.11 0.00e+00 1177.00
IUUC-Dor-030176 Dipodomys ordii 73.33 0.00e+00 1117.00
IUUC-Eca-033949 Equus caballus 76.23 0.00e+00 1184.00
IUUC-Eeu-034529 Erinaceus europaeus 78.57 0.00e+00 962.00
IUUC-Fca-036236 Felis catus 76.48 0.00e+00 1197.00
IUUC-Fal-036948 Ficedula albicollis 83.95 0.00e+00 1262.00
IUUC-Gmo-038842 Gadus morhua 84.13 0.00e+00 976.00
IUUC-Gga-040617 Gallus gallus 82.01 0.00e+00 1293.00
IUUC-Gac-041338 Gasterosteus aculeatus 67.60 0.00e+00 1038.00
IUUC-Ggo-045278 Gorilla gorilla 75.99 0.00e+00 1214.00
IUUC-Hsa-046148 Homo sapiens 75.96 0.00e+00 1215.00
IUUC-Itr-047945 Ictidomys tridecemlineatus 89.35 0.00e+00 995.00
IUUC-Lch-050663 Latimeria chalumnae 69.17 0.00e+00 1110.00
IUUC-Loc-052604 Lepisosteus oculatus 69.02 0.00e+00 1067.00
IUUC-Laf-053944 Loxodonta africana 75.74 0.00e+00 1192.00
IUUC-Mcc-055655 Macaca mulatta 75.74 0.00e+00 1209.00
IUUC-Meu-055953 Macropus eugenii 64.94 0.00e+00 995.00
IUUC-Mga-060190 Meleagris gallopavo 81.64 0.00e+00 1284.00
IUUC-Mmr-060896 Microcebus murinus 75.96 0.00e+00 1186.00
IUUC-Mdo-062536 Monodelphis domestica 76.75 0.00e+00 1229.00
IUUC-Mmu-064017 Mus musculus 75.71 0.00e+00 1176.00
IUUC-Mpu-066608 Mustela putorius furo 73.92 0.00e+00 1128.00
IUUC-Mlu-067623 Myotis lucifugus 73.40 0.00e+00 1137.00
IUUC-Nle-069496 Nomascus leucogenys 73.68 0.00e+00 1162.00
IUUC-Opr-071054 Ochotona princeps 89.58 0.00e+00 1058.00
IUUC-Ont-071279 Oreochromis niloticus 67.32 0.00e+00 1014.00
IUUC-Oan-073512 Ornithorhynchus anatinus 73.16 0.00e+00 1132.00
IUUC-Ocu-074271 Oryctolagus cuniculus 74.54 0.00e+00 1172.00
IUUC-Ola-087237 Oryzias latipes 65.43 0.00e+00 992.00
IUUC-Oga-088164 Otolemur garnettii 76.35 0.00e+00 1191.00
IUUC-Oar-089698 Ovis aries 75.83 0.00e+00 1167.00
IUUC-Ptr-091306 Pan troglodytes 74.51 0.00e+00 1182.00
IUUC-Pan-092814 Papio anubis 79.44 0.00e+00 1136.00
IUUC-Pfo-096709 Poecilia formosa 84.79 0.00e+00 985.00
IUUC-Pab-098494 Pongo abelii 73.77 0.00e+00 1165.00
IUUC-Pca-100596 Procavia capensis 73.26 0.00e+00 972.00
IUUC-Pva-103154 Pteropus vampyrus 80.85 0.00e+00 1058.00
IUUC-Rno-104954 Rattus norvegicus 75.59 0.00e+00 1168.00
IUUC-Sha-106781 Sarcophilus harrisii 76.66 0.00e+00 1241.00
IUUC-Ssc-116307 Sus scrofa 72.30 0.00e+00 1099.00
IUUC-Tbe-127793 Tupaia belangeri 72.42 0.00e+00 997.00
IUUC-Ttr-128275 Tursiops truncatus 89.93 0.00e+00 1073.00
IUUC-Xtr-132866 Xenopus tropicalis 77.85 0.00e+00 1023.00
Created Date 25-Jun-2017

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