iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120801

UUCD1 version

UUC-TeN-00740

Ensembl Protein ID

ENSTNIP00000001641.1

UniProt Accession

H3C075; H3C075_TETNG

Protein Name

E3 ubiquitin-protein ligase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000008850.1	ENSTNIT00000011889.1	ENSTNIP00000011701.1
ENSTNIG00000008850.1	ENSTNIT00000000340.1	ENSTNIP00000001641.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-130	435.9	550	883

Active Site

Position(s)	Description	Evidence
852	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllg.kalqdgrlld 89
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr+++ kal++g+++d
   Q: 550  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAmKALYHGKFID 637
           6799********************************************************9.89**************66********* PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvv 178
           + ++ +fyk++l+kk +l+dle++dpe+y+s++++ken   ++ee+g++l f ++ eilg+++++eLk+gGen+ Vt+eNkeeY++l++
   Q: 638  TGFTLPFYKQMLDKKPTLKDLESIDPEFYNSIMWVKEN---NLEECGVELFFAQDMEILGKVTSHELKEGGENELVTEENKEEYISLLT 723
           ************************************99...9*********************************************** PP
   S: 179  eyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqF 267
           ++r+++g+keq+ af +Gfnev+ple+l++F+e+elel++cG++eid+ d++k+t y++ yt++s++i+wFw+v++e+++e+r ++LqF
   Q: 724  NWRFTRGVKEQTRAFLDGFNEVVPLEWLRYFDEKELELMLCGMQEIDLADWQKNTIYRH-YTKNSKQIHWFWQVVKEMDNEKRIRLLQF 811
           *********************************************************99.***************************** PP
   S: 268  vTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           vTg++rlP+gGf el     p++f+i k +++++lP+s+TCfn+L+LP+Y s e+l+ekL++Aieet+gF++
   Q: 812  VTGTCRLPVGGFSELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYRSLEQLREKLMFAIEETEGFGQ 883
           **********************************************************************96 PP

Organism

Tetraodon nigroviridis

Protein Sequence
(Fasta)

FVEVTADGLT SETKKTGKRS GHLELQWNED LTLNVTPQSR LDLKLWSCLT LRKELLGFAT 60
IDLLDTLRTY DGKMENVQLS LVLQTENKGS VVTGGELNVC LDGMVVDLGS LLNGSTAADS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAACTG CCAGTGTGAA CAGACCTGGC AGTGCCCAGA CCACCGAGAA GTCCCAGCTG 60
ATCTTAAAAG GTAACCGTGG TATATTTCCT GTTTCCATAA CAACACAGAA CTGTTCAGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0060021--P:palate development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	88.01	0.00e+00	1120.00
IUUC-Aca-004291	Anolis carolinensis	68.97	0.00e+00	1201.00
IUUC-Bta-013231	Bos taurus	90.14	0.00e+00	1108.00
IUUC-Cja-019455	Callithrix jacchus	67.22	0.00e+00	1167.00
IUUC-Cfa-021017	Canis familiaris	90.67	0.00e+00	1113.00
IUUC-Cpo-021988	Cavia porcellus	67.34	0.00e+00	1166.00
IUUC-Csa-023549	Chlorocebus sabaeus	66.92	0.00e+00	1172.00
IUUC-Dre-028513	Danio rerio	94.06	0.00e+00	1167.00
IUUC-Dno-028976	Dasypus novemcinctus	68.80	0.00e+00	1176.00
IUUC-Dor-030176	Dipodomys ordii	90.67	0.00e+00	1107.00
IUUC-Eca-033949	Equus caballus	90.14	0.00e+00	1113.00
IUUC-Eeu-034529	Erinaceus europaeus	88.22	0.00e+00	951.00
IUUC-Fca-036236	Felis catus	82.44	0.00e+00	1135.00
IUUC-Fal-036948	Ficedula albicollis	90.96	0.00e+00	1125.00
IUUC-Gmo-038842	Gadus morhua	92.43	0.00e+00	1093.00
IUUC-Gga-040617	Gallus gallus	88.69	0.00e+00	1142.00
IUUC-Gac-041338	Gasterosteus aculeatus	93.69	0.00e+00	1133.00
IUUC-Ggo-045278	Gorilla gorilla	67.11	0.00e+00	1168.00
IUUC-Hsa-046148	Homo sapiens	67.11	0.00e+00	1167.00
IUUC-Lch-050663	Latimeria chalumnae	89.36	0.00e+00	1141.00
IUUC-Loc-052604	Lepisosteus oculatus	73.15	0.00e+00	1291.00
IUUC-Laf-053944	Loxodonta africana	88.61	0.00e+00	1124.00
IUUC-Mcc-055655	Macaca mulatta	66.78	0.00e+00	1162.00
IUUC-Meu-055953	Macropus eugenii	75.57	0.00e+00	964.00
IUUC-Mga-060190	Meleagris gallopavo	89.13	0.00e+00	1143.00
IUUC-Mmr-060896	Microcebus murinus	81.71	0.00e+00	1115.00
IUUC-Mdo-062536	Monodelphis domestica	90.58	0.00e+00	1127.00
IUUC-Mmu-064017	Mus musculus	86.51	0.00e+00	1122.00
IUUC-Mpu-066608	Mustela putorius furo	66.00	0.00e+00	1124.00
IUUC-Mlu-067623	Myotis lucifugus	66.82	0.00e+00	1120.00
IUUC-Nle-069496	Nomascus leucogenys	65.02	0.00e+00	1118.00
IUUC-Opr-071054	Ochotona princeps	89.79	0.00e+00	1098.00
IUUC-Ont-071279	Oreochromis niloticus	80.80	0.00e+00	1387.00
IUUC-Oan-073512	Ornithorhynchus anatinus	85.86	0.00e+00	1079.00
IUUC-Ocu-074271	Oryctolagus cuniculus	80.69	0.00e+00	1110.00
IUUC-Ola-087237	Oryzias latipes	92.24	0.00e+00	1138.00
IUUC-Oga-088164	Otolemur garnettii	81.18	0.00e+00	1116.00
IUUC-Oar-089698	Ovis aries	90.14	0.00e+00	1108.00
IUUC-Ptr-091306	Pan troglodytes	66.12	0.00e+00	1140.00
IUUC-Pan-092814	Papio anubis	74.83	0.00e+00	1090.00
IUUC-Pfo-096709	Poecilia formosa	85.75	0.00e+00	1161.00
IUUC-Pab-098494	Pongo abelii	80.36	0.00e+00	1115.00
IUUC-Pca-100596	Procavia capensis	79.32	0.00e+00	979.00
IUUC-Pva-103154	Pteropus vampyrus	81.59	0.00e+00	1074.00
IUUC-Rno-104954	Rattus norvegicus	81.34	0.00e+00	1107.00
IUUC-Sha-106781	Sarcophilus harrisii	70.90	0.00e+00	1264.00
IUUC-Ssc-116307	Sus scrofa	65.61	0.00e+00	1130.00
IUUC-Tru-118287	Takifugu rubripes	85.11	0.00e+00	1192.00
IUUC-Tbe-127793	Tupaia belangeri	72.99	0.00e+00	959.00
IUUC-Ttr-128275	Tursiops truncatus	90.14	0.00e+00	1111.00
IUUC-Xtr-132866	Xenopus tropicalis	85.59	0.00e+00	1093.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence