iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000000628.3	ENSMMUT00000000903.3	ENSMMUP00000000841.3
ENSMMUG00000000628.3	ENSMMUT00000019464.3	ENSMMUP00000018225.3
ENSMMUG00000000628.3	ENSMMUT00000073699.1	ENSMMUP00000046917.1
ENSMMUG00000000628.3	ENSMMUT00000053961.1	ENSMMUP00000059201.1
ENSMMUG00000000628.3	ENSMMUT00000060752.1	ENSMMUP00000057466.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.60e-107	360.9	547	873

Active Site

Position(s)	Description	Evidence
842	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e+ k  ++ np+s+    e +  F+++G++lg+a++++ +ld+
   Q: 547  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWF-NPSSF----ETEGQFTLIGIVLGLAIYNNCILDV 630
           689******************************************998888876.88888....789********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.lgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl + +p ly+slk ++e+ e ++e+  + +tf++s++  +g+   ++Lk++G++ip+tneN++e+v+l+ 
   Q: 631  HFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEY-EGNVEDD-MMITFQISQTDlFGNPMMYDLKENGDKIPITNENRKEFVNLYS 717
           *************************************.7799986.99***9665444******************************* PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y+l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++l+++t+y+ggyt+ds  i+ Fwe++++f++e+++ fLq
   Q: 718  DYILNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQ 806
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d +rlP+s+TCfn+L LPeYsske+lke+Ll Ai+++kgF++
   Q: 807  FTTGTDRAPVGGLGKLK---MIIAKNGPDtERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 873
           *****************...8888866666**************************************97 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

FTKLHGWPRS GEPQSDDIEA SRMKRAAAKH LIERYYHQLT EGCGNEACTN EFCASCPTFL 60
RMDNNAAAIK ALELYKINAK LCDPHPSKKG ASSAYLENSK GAPNNSCSEI KMNKKGTRID 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGTTACAG TGGAGGTAAA AGGAGTGGCT TGCAGGATGG AGAAGCTGCA CCAGTGTTAT 60
TGGAAGTGAG CCACCATTTG AATTTGCTAG CTCATGCTGC AGTATTCAGA TTAGTGGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002214	Ailuropoda melanoleuca	98.01	0.00e+00	1610.00
IUUC-Atr-003144	Amborella trichopoda	45.80	7.00e-96	344.00
IUUC-Apl-003742	Anas platyrhynchos	91.62	0.00e+00	1583.00
IUUC-Aca-004873	Anolis carolinensis	93.60	0.00e+00	1597.00
IUUC-Ame-011166	Astyanax mexicanus	86.71	0.00e+00	1451.00
IUUC-Bta-013286	Bos taurus	97.24	0.00e+00	1578.00
IUUC-Cja-019707	Callithrix jacchus	98.74	0.00e+00	1663.00
IUUC-Cfa-020154	Canis familiaris	97.92	0.00e+00	1617.00
IUUC-Cpo-021292	Cavia porcellus	97.42	0.00e+00	1598.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	49.06	2.00e-82	298.00
IUUC-Csa-023378	Chlorocebus sabaeus	100.00	0.00e+00	1670.00
IUUC-Cho-025059	Choloepus hoffmanni	93.57	0.00e+00	1509.00
IUUC-Cin-025643	Ciona intestinalis	45.03	0.00e+00	717.00
IUUC-Csv-026282	Ciona savignyi	45.10	0.00e+00	674.00
IUUC-Cme-027151	Cyanidioschyzon merolae	44.02	3.00e-101	363.00
IUUC-Dre-027901	Danio rerio	86.23	0.00e+00	1436.00
IUUC-Dno-029320	Dasypus novemcinctus	97.58	0.00e+00	1620.00
IUUC-Dor-030756	Dipodomys ordii	95.18	0.00e+00	743.00
IUUC-Dme-032035	Drosophila melanogaster	42.86	7.00e-166	578.00
IUUC-Eca-033843	Equus caballus	97.78	0.00e+00	1570.00
IUUC-Eeu-035109	Erinaceus europaeus	96.12	0.00e+00	1557.00
IUUC-Fca-036344	Felis catus	96.20	0.00e+00	1612.00
IUUC-Fal-036747	Ficedula albicollis	91.62	0.00e+00	1583.00
IUUC-Gmo-038840	Gadus morhua	63.58	0.00e+00	1103.00
IUUC-Gga-040399	Gallus gallus	91.50	0.00e+00	1582.00
IUUC-Gac-041933	Gasterosteus aculeatus	84.79	0.00e+00	1388.00
IUUC-Ggo-044804	Gorilla gorilla	99.20	0.00e+00	1666.00
IUUC-Hsa-045727	Homo sapiens	99.20	0.00e+00	1666.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	94.26	0.00e+00	1516.00
IUUC-Lch-050197	Latimeria chalumnae	90.90	0.00e+00	1546.00
IUUC-Loc-052743	Lepisosteus oculatus	88.14	0.00e+00	1517.00
IUUC-Lma-053245	Leptosphaeria maculans	33.87	6.00e-57	216.00
IUUC-Laf-053615	Loxodonta africana	96.08	0.00e+00	1605.00
IUUC-Meu-056061	Macropus eugenii	90.14	0.00e+00	1426.00
IUUC-Mga-059271	Meleagris gallopavo	90.60	0.00e+00	1560.00
IUUC-Mmr-061288	Microcebus murinus	98.05	0.00e+00	1654.00
IUUC-Mdo-062975	Monodelphis domestica	95.86	0.00e+00	1598.00
IUUC-Mmu-063674	Mus musculus	95.72	0.00e+00	1573.00
IUUC-Mpu-066568	Mustela putorius furo	98.27	0.00e+00	1640.00
IUUC-Mlu-067522	Myotis lucifugus	89.23	0.00e+00	1494.00
IUUC-Nle-069505	Nomascus leucogenys	99.20	0.00e+00	1666.00
IUUC-Opr-070570	Ochotona princeps	89.65	0.00e+00	1460.00
IUUC-Ont-071527	Oreochromis niloticus	84.53	0.00e+00	1462.00
IUUC-Oan-073446	Ornithorhynchus anatinus	91.19	0.00e+00	1051.00
IUUC-Ocu-074922	Oryctolagus cuniculus	95.88	0.00e+00	1622.00
IUUC-Ola-086996	Oryzias latipes	85.28	0.00e+00	1464.00
IUUC-Oga-088261	Otolemur garnettii	98.71	0.00e+00	1625.00
IUUC-Oar-090024	Ovis aries	97.24	0.00e+00	1578.00
IUUC-Ptr-090455	Pan troglodytes	99.20	0.00e+00	1666.00
IUUC-Pan-092509	Papio anubis	97.99	0.00e+00	1500.00
IUUC-Psi-092974	Pelodiscus sinensis	91.72	0.00e+00	1551.00
IUUC-Pma-094643	Petromyzon marinus	71.61	0.00e+00	1257.00
IUUC-Pno-094886	Phaeosphaeria nodorum	35.32	1.00e-57	219.00
IUUC-Pfo-096905	Poecilia formosa	85.24	0.00e+00	1459.00
IUUC-Pab-097840	Pongo abelii	97.30	0.00e+00	1593.00
IUUC-Pca-100869	Procavia capensis	96.72	0.00e+00	1588.00
IUUC-Pva-103040	Pteropus vampyrus	97.02	0.00e+00	667.00
IUUC-Rno-105453	Rattus norvegicus	95.84	0.00e+00	1578.00
IUUC-Sha-107651	Sarcophilus harrisii	95.86	0.00e+00	1598.00
IUUC-Smo-108858	Selaginella moellendorffii	49.65	8.00e-116	411.00
IUUC-Sar-113293	Sorex araneus	97.19	0.00e+00	1594.00
IUUC-Ssc-115979	Sus scrofa	97.31	0.00e+00	1593.00
IUUC-Tgu-116901	Taeniopygia guttata	91.62	0.00e+00	1582.00
IUUC-Tru-118368	Takifugu rubripes	85.90	0.00e+00	1461.00
IUUC-Tsy-119516	Tarsius syrichta	94.71	0.00e+00	1516.00
IUUC-Tni-120143	Tetraodon nigroviridis	83.72	0.00e+00	1452.00
IUUC-Tbe-127484	Tupaia belangeri	92.44	0.00e+00	1105.00
IUUC-Ttr-129078	Tursiops truncatus	97.08	0.00e+00	1568.00
IUUC-Vpa-130312	Vicugna pacos	89.80	0.00e+00	1350.00
IUUC-Xtr-132881	Xenopus tropicalis	91.47	0.00e+00	1547.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence