iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000032192.9	ENSMUST00000213990.1	ENSMUSP00000149938.1
ENSMUSG00000032192.9	ENSMUST00000215002.1	ENSMUSP00000150270.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
PHOSIDA	mUbiSiDa
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.00e-42	141.2	235	275
UBD/Beta-Prp	2.00e-54	185.9	189	394

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf....sdtllvsGsdDgtikvWDlrtgvllk 37
           gH ++v cl++    +++++vsG+ D++ +vWD+r+g +++
   Q: 235  GHGADVLCLDLapseTGNTFVSGGCDKKAMVWDMRSGQCVQ 275
           8***********9644499********************98 PP

UBD/Beta-Prp

   S: 46   rslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp..sgdklvsGshdrtirvwdletgqcleet 132
           +s+  h++  +a++f +++  ++t+s D+t  +wd+++g+ +++++gh ++vl+l++ p  +g+++vsG+ d+ ++vwd+++gqc++  
   Q: 189  KSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPseTGNTFVSGGCDKKAMVWDMRSGQCVQ-A 276
           567889999*********99***************************************9778************************.* PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl.tgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlng 220
           ++ h++ vn+v++ p+g+ ++sGs+D t+rl+dl+ ++ +    ++       s++f+ +g+ l +g +d t+++wd+ +g+ v +l g
   Q: 277  FETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYsKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFG 365
           *******************************************5333556778999********************************* PP
   S: 221  htdnvksvrfspnderlvsgssDgsiriW 249
           h++ v+ +r+sp+++ + sgs D ++r+W
   Q: 366  HENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
           ***************************** PP

Organism

Mus musculus

Functional Description
(View)

Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Protein Sequence
(Fasta)

MCDQTFLVNV FGSCDKCFKQ RALRPVFKKS QQLNYCSTCA EIMATDGLHE NETLASLKSE 60
AESLKGKLEE ERAKLHDVEL HQVAERVEAL GQFVMKTRRT LKGHGNKVLC MDWCKDKRRI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGACCAAT GGCTCAAATC TTCACACCAC CGCAGTAACC TCCCTCGTTT CTGGCCAGCC 60
ACCCCAGGTG TTCATTGCTC TGTAAGGTAT GTACTCTTTA ACCTCAGGGA ACTTGTGCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0472--Membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0807--Transducer
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR016346--Guanine_nucleotide-bd_bsu
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0043209--C:myelin sheath
GO:0005634--C:nucleus
GO:0001917--C:photoreceptor inner segment
GO:0001750--C:photoreceptor outer segment
GO:0005886--C:plasma membrane
GO:0051087--F:chaperone binding
GO:0031682--F:G-protein gamma-subunit binding
GO:0005096--F:GTPase activator activity
GO:0004871--F:signal transducer activity
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:1901386--P:negative regulation of voltage-gated calcium channel activity
GO:0043547--P:positive regulation of GTPase activity

KEGG

mmu:14697

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001811	Ailuropoda melanoleuca	92.41	0.00e+00	766.00
IUUC-Apl-003399	Anas platyrhynchos	98.40	0.00e+00	649.00
IUUC-Aca-004861	Anolis carolinensis	92.66	0.00e+00	777.00
IUUC-Ame-011851	Astyanax mexicanus	91.74	0.00e+00	685.00
IUUC-Bta-012438	Bos taurus	99.15	0.00e+00	731.00
IUUC-Cel-018408	Caenorhabditis elegans	64.64	5.00e-139	487.00
IUUC-Cja-019086	Callithrix jacchus	99.24	0.00e+00	815.00
IUUC-Cfa-021255	Canis familiaris	97.20	0.00e+00	758.00
IUUC-Cpo-021398	Cavia porcellus	97.22	0.00e+00	804.00
IUUC-Csa-023776	Chlorocebus sabaeus	99.15	0.00e+00	731.00
IUUC-Cin-025305	Ciona intestinalis	57.65	2.00e-131	461.00
IUUC-Csv-026058	Ciona savignyi	57.81	2.00e-127	448.00
IUUC-Dre-028432	Danio rerio	84.81	0.00e+00	679.00
IUUC-Dno-029958	Dasypus novemcinctus	86.55	5.00e-147	513.00
IUUC-Dor-031013	Dipodomys ordii	99.61	4.00e-153	533.00
IUUC-Dme-031889	Drosophila melanogaster	68.90	5.00e-149	520.00
IUUC-Eca-033977	Equus caballus	93.42	0.00e+00	768.00
IUUC-Eeu-035079	Erinaceus europaeus	97.70	0.00e+00	798.00
IUUC-Fca-035693	Felis catus	91.94	0.00e+00	760.00
IUUC-Fal-037345	Ficedula albicollis	98.02	0.00e+00	728.00
IUUC-Gmo-039222	Gadus morhua	90.93	0.00e+00	658.00
IUUC-Gga-040320	Gallus gallus	98.02	0.00e+00	728.00
IUUC-Gac-042644	Gasterosteus aculeatus	91.22	0.00e+00	687.00
IUUC-Ggo-044489	Gorilla gorilla	95.20	0.00e+00	776.00
IUUC-Hsa-046434	Homo sapiens	99.24	0.00e+00	821.00
IUUC-Itr-048771	Ictidomys tridecemlineatus	93.35	1.00e-176	611.00
IUUC-Loc-052790	Lepisosteus oculatus	90.31	0.00e+00	723.00
IUUC-Laf-054255	Loxodonta africana	97.71	0.00e+00	803.00
IUUC-Mcc-055610	Macaca mulatta	98.73	0.00e+00	811.00
IUUC-Meu-056819	Macropus eugenii	85.97	0.00e+00	692.00
IUUC-Mga-059740	Meleagris gallopavo	86.78	0.00e+00	715.00
IUUC-Mmr-061221	Microcebus murinus	98.99	0.00e+00	818.00
IUUC-Mdo-062619	Monodelphis domestica	97.73	0.00e+00	724.00
IUUC-Mpu-065766	Mustela putorius furo	99.00	0.00e+00	627.00
IUUC-Mlu-067221	Myotis lucifugus	91.44	0.00e+00	751.00
IUUC-Nle-069515	Nomascus leucogenys	99.37	0.00e+00	659.00
IUUC-Opr-070195	Ochotona princeps	90.84	0.00e+00	729.00
IUUC-Ont-071535	Oreochromis niloticus	78.73	3.00e-172	597.00
IUUC-Oan-072899	Ornithorhynchus anatinus	97.30	4.00e-107	380.00
IUUC-Ocu-074666	Oryctolagus cuniculus	99.34	0.00e+00	629.00
IUUC-Ola-086578	Oryzias latipes	92.33	0.00e+00	652.00
IUUC-Oga-089090	Otolemur garnettii	98.74	0.00e+00	815.00
IUUC-Oar-090017	Ovis aries	92.39	0.00e+00	745.00
IUUC-Ptr-091280	Pan troglodytes	89.87	0.00e+00	727.00
IUUC-Pan-092198	Papio anubis	98.74	0.00e+00	660.00
IUUC-Psi-093030	Pelodiscus sinensis	85.57	0.00e+00	720.00
IUUC-Pma-094140	Petromyzon marinus	83.10	3.00e-105	373.00
IUUC-Pfo-097182	Poecilia formosa	92.07	0.00e+00	666.00
IUUC-Pab-098157	Pongo abelii	99.43	0.00e+00	735.00
IUUC-Pca-100988	Procavia capensis	77.47	2.00e-171	595.00
IUUC-Pva-102232	Pteropus vampyrus	86.57	3.00e-177	613.00
IUUC-Rno-105526	Rattus norvegicus	96.34	0.00e+00	697.00
IUUC-Sce-106298	Saccharomyces cerevisiae	34.54	1.00e-67	250.00
IUUC-Sha-106754	Sarcophilus harrisii	96.46	0.00e+00	757.00
IUUC-Ssc-115390	Sus scrofa	98.74	0.00e+00	815.00
IUUC-Tgu-117377	Taeniopygia guttata	87.28	0.00e+00	702.00
IUUC-Tru-117938	Takifugu rubripes	92.07	0.00e+00	654.00
IUUC-Tsy-119392	Tarsius syrichta	84.81	0.00e+00	667.00
IUUC-Tni-119834	Tetraodon nigroviridis	73.16	7.00e-166	576.00
IUUC-Tbe-127469	Tupaia belangeri	95.74	0.00e+00	732.00
IUUC-Ttr-128252	Tursiops truncatus	95.45	0.00e+00	776.00
IUUC-Vpa-130173	Vicugna pacos	80.36	4.00e-157	547.00
IUUC-Xtr-131803	Xenopus tropicalis	91.39	0.00e+00	728.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence