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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-105421
Ensembl Protein ID ENSRNOP00000027813.5
UniProt Accession F1LWB1; F1LWB1_RAT
Genbank Protein ID ENSRNOP00000027813
Protein Name Vav guanine nucleotide exchange factor 3
Genbank Nucleotide ID AABR07012868
Gene Name Vav3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000020485.6 ENSRNOT00000027813.6 ENSRNOP00000027813.5
ENSRNOG00000020485.6 ENSRNOT00000077883.1 ENSRNOP00000073138.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 2.40e-14 53.4 794 845
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+l kGd+v++   +   +gW++g  e +g+ G fP+ +ve+
   Q: 794  IARYDFCARDMRELSLLKGDMVKIY-TKMSANGWWRG--EVNGRVGWFPSTYVEE 845
           688*********************9.999999*****..9*************86 PP
   
Organism Rattus norvegicus
Protein Sequence
(Fasta)
MEPWKQCAQW LIHCKVLPAN HRVTWDSAQV FDLAQTLRDG VLLCQLLNNL RPHSINLKEI 60
NLRPQMSQFL CLKNIRTFLA ACCDTFGMKK SELFEAFDLF DVRDFGKVIE TLSRLSRTPI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105421|UBD,SH3|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGAGCCGT GGAAGCAGTG CGCTCAGTGG CTCATCCACT GCAAAGTGCT GCCCGCCAAC 60
CACCGGGTGA CCTGGGACTC GGCGCAGGTG TTCGACCTGG CGCAGACCCT CCGCGATGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105421|UBD,SH3|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc
Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain
IPR003096--SM22_calponin
PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2
Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF00018--SH3_1
PF07653--SH3_2
PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00888--SM22CALPONIN
SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0050853--P:B cell receptor signaling pathway
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007229--P:integrin-mediated signaling pathway
GO:0030032--P:lamellipodium assembly
GO:0030593--P:neutrophil chemotaxis
GO:0030890--P:positive regulation of B cell proliferation
GO:0045785--P:positive regulation of cell adhesion
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0008361--P:regulation of cell size
GO:0035023--P:regulation of Rho protein signal transduction
GO:0042493--P:response to drug
GO:0007264--P:small GTPase mediated signal transduction
GO:0006906--P:vesicle fusion
KEGG rno:295378
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001362 Ailuropoda melanoleuca 94.81 0.00e+00 1588.00
IUUC-Apl-003734 Anas platyrhynchos 86.01 0.00e+00 1346.00
IUUC-Aca-004477 Anolis carolinensis 81.26 0.00e+00 1384.00
IUUC-Ame-011279 Astyanax mexicanus 66.78 0.00e+00 1118.00
IUUC-Bta-012722 Bos taurus 93.86 0.00e+00 1576.00
IUUC-Cja-018941 Callithrix jacchus 94.87 0.00e+00 1570.00
IUUC-Cfa-020266 Canis familiaris 94.61 0.00e+00 1406.00
IUUC-Cpo-021966 Cavia porcellus 94.26 0.00e+00 1377.00
IUUC-Csa-023892 Chlorocebus sabaeus 94.37 0.00e+00 1452.00
IUUC-Dre-028199 Danio rerio 66.36 0.00e+00 1125.00
IUUC-Dno-029474 Dasypus novemcinctus 93.98 0.00e+00 1573.00
IUUC-Eca-033961 Equus caballus 94.61 0.00e+00 1434.00
IUUC-Eeu-034719 Erinaceus europaeus 74.63 0.00e+00 780.00
IUUC-Fca-036572 Felis catus 94.37 0.00e+00 1549.00
IUUC-Fal-036802 Ficedula albicollis 84.00 0.00e+00 1466.00
IUUC-Gmo-039409 Gadus morhua 70.19 0.00e+00 1170.00
IUUC-Gga-040884 Gallus gallus 85.01 0.00e+00 1459.00
IUUC-Gac-041395 Gasterosteus aculeatus 71.95 0.00e+00 1246.00
IUUC-Ggo-044460 Gorilla gorilla 92.52 0.00e+00 1373.00
IUUC-Hsa-046099 Homo sapiens 91.66 0.00e+00 1571.00
IUUC-Itr-048144 Ictidomys tridecemlineatus 91.18 0.00e+00 1380.00
IUUC-Lch-049650 Latimeria chalumnae 80.28 1.00e-106 379.00
IUUC-Loc-052487 Lepisosteus oculatus 73.27 0.00e+00 1243.00
IUUC-Laf-054564 Loxodonta africana 93.15 0.00e+00 1565.00
IUUC-Mcc-054622 Macaca mulatta 91.66 0.00e+00 1572.00
IUUC-Meu-056680 Macropus eugenii 84.06 0.00e+00 1400.00
IUUC-Mga-060013 Meleagris gallopavo 81.56 0.00e+00 1382.00
IUUC-Mmr-061251 Microcebus murinus 90.27 0.00e+00 1592.00
IUUC-Mdo-061875 Monodelphis domestica 91.62 0.00e+00 1547.00
IUUC-Mmu-063735 Mus musculus 97.76 0.00e+00 1663.00
IUUC-Mpu-065856 Mustela putorius furo 94.33 0.00e+00 1580.00
IUUC-Mlu-068108 Myotis lucifugus 89.03 0.00e+00 1497.00
IUUC-Nle-069863 Nomascus leucogenys 90.33 0.00e+00 1534.00
IUUC-Opr-070372 Ochotona princeps 82.60 0.00e+00 1035.00
IUUC-Ont-072286 Oreochromis niloticus 72.10 0.00e+00 1233.00
IUUC-Ocu-074194 Oryctolagus cuniculus 95.28 0.00e+00 1593.00
IUUC-Ola-086336 Oryzias latipes 70.47 0.00e+00 1217.00
IUUC-Oar-089272 Ovis aries 93.51 0.00e+00 1611.00
IUUC-Ptr-090652 Pan troglodytes 92.82 0.00e+00 1575.00
IUUC-Pan-092550 Papio anubis 90.99 0.00e+00 1388.00
IUUC-Psi-093784 Pelodiscus sinensis 79.83 0.00e+00 1249.00
IUUC-Ppa-095161 Physcomitrella patens 43.64 2.00e-09 56.60
IUUC-Pfo-097308 Poecilia formosa 69.59 0.00e+00 1223.00
IUUC-Pab-098698 Pongo abelii 92.68 0.00e+00 1573.00
IUUC-Pva-102262 Pteropus vampyrus 94.60 0.00e+00 1523.00
IUUC-Sha-107325 Sarcophilus harrisii 91.62 0.00e+00 1566.00
IUUC-Sar-113456 Sorex araneus 88.55 0.00e+00 1503.00
IUUC-Tgu-116595 Taeniopygia guttata 82.23 0.00e+00 1374.00
IUUC-Tru-117884 Takifugu rubripes 67.21 0.00e+00 1207.00
IUUC-Tsy-119429 Tarsius syrichta 86.52 0.00e+00 1305.00
IUUC-Tni-119951 Tetraodon nigroviridis 69.01 0.00e+00 1150.00
IUUC-Tbe-127995 Tupaia belangeri 83.25 1.00e-174 607.00
IUUC-Ttr-128281 Tursiops truncatus 94.10 0.00e+00 1572.00
IUUC-Xtr-132427 Xenopus tropicalis 72.03 0.00e+00 1282.00
Created Date 25-Jun-2017

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