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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046224
UUCD1 version UUC-HoS-00203
Ensembl Protein ID ENSP00000430237.1
UniProt Accession Q86XS8; J3KN31; Q32P32; Q59EL1; Q641P9; Q6P177; Q7L2U2; Q9P0J9; GOLI_HUMAN
Genbank Protein ID AAM08686.1; BAD93037.1; EAW53773.1; AAH17100.2; AAH65244.1; AAH82267.1; AAI08307.1; AAF67007.1
Protein Name E3 ubiquitin-protein ligase RNF130; Goliath homolog; RING finger protein 130; RING-type E3 ubiquitin transferase RNF130
Genbank Nucleotide ID AY083998; AB209800; AC010285; BC017100; BC065244; BC082267; BC108306; AF155650
Gene Name RNF130
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000113269.13 ENST00000522208.6 ENSP00000429509.1
ENSG00000113269.13 ENST00000521389.5 ENSP00000430237.1
ENSG00000113269.13 ENST00000261947.4 ENSP00000261947.4
ENSG00000113269.13 ENST00000520911.5 ENSP00000430999.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRID
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 16549277
Classification
Family E-value Score Start End
E3 activity/RING/RING 7.40e-07 31.3 264 305
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           Ca+C e++   d +++lpC+Hvfh++C+  w       s + +CP C+
   Q: 264  CAVCIESYkqNDVVRILPCKHVFHKSCVDPW------LSEHCTCPMCK 305
           ********76666******************......**********6 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin-protein ligase.
 May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin-protein ligase.
Protein Sequence
(Fasta)
MSCAGRAGPA RLAALALLTC SLWPARADNA SQEYYTALIN VTVQEPGRGA PLTFRIDRGR 60
YGLDSPKAEV RGQVLAPLPL HGVADHLGCD PQTRFFVPPN IKQWIALLQR GNCTFKEKIS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046224|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGGCAGCCGC GCGAGAGGGA CTTTGTGTTC CGCTGACCCT CCTCGGGGCG CTTCCTCCCG 60
TGCCGCCCTT CCCCTCCCCC GCCGCGTCCT TGCGAGGCGC CTCCCATTCG GTGGGACCGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046224|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003137--PA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF02225--PA
PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0012501--P:programmed cell death
KEGG hsa:55819
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001953 Ailuropoda melanoleuca 98.81 0.00e+00 693.00
IUUC-Apl-003520 Anas platyrhynchos 88.59 1.00e-178 618.00
IUUC-Aca-005099 Anolis carolinensis 80.25 0.00e+00 627.00
IUUC-Afu-009087 Aspergillus fumigatus 30.08 2.00e-13 69.30
IUUC-Ame-010838 Astyanax mexicanus 68.23 6.00e-143 500.00
IUUC-Bta-013574 Bos taurus 98.75 0.00e+00 830.00
IUUC-Cja-019048 Callithrix jacchus 95.70 0.00e+00 819.00
IUUC-Cfa-020217 Canis familiaris 98.55 0.00e+00 705.00
IUUC-Cpo-021540 Cavia porcellus 97.35 0.00e+00 685.00
IUUC-Csa-023073 Chlorocebus sabaeus 100.00 0.00e+00 836.00
IUUC-Cho-024861 Choloepus hoffmanni 95.24 0.00e+00 671.00
IUUC-Dre-028252 Danio rerio 68.23 3.00e-153 535.00
IUUC-Dno-029343 Dasypus novemcinctus 98.91 2.00e-163 568.00
IUUC-Dor-030591 Dipodomys ordii 99.11 0.00e+00 694.00
IUUC-Ete-032447 Echinops telfairi 97.62 0.00e+00 642.00
IUUC-Eca-034368 Equus caballus 99.10 0.00e+00 686.00
IUUC-Eeu-034965 Erinaceus europaeus 89.58 2.00e-177 615.00
IUUC-Fca-036053 Felis catus 99.11 0.00e+00 694.00
IUUC-Fal-037232 Ficedula albicollis 85.46 0.00e+00 695.00
IUUC-Gmo-039437 Gadus morhua 65.16 3.00e-129 454.00
IUUC-Gga-041046 Gallus gallus 82.32 2.00e-180 625.00
IUUC-Gac-042488 Gasterosteus aculeatus 60.92 5.00e-133 467.00
IUUC-Ggo-044560 Gorilla gorilla 98.81 0.00e+00 691.00
IUUC-Itr-048004 Ictidomys tridecemlineatus 99.41 0.00e+00 697.00
IUUC-Lch-050557 Latimeria chalumnae 75.52 7.00e-178 616.00
IUUC-Loc-052249 Lepisosteus oculatus 74.10 5.00e-177 613.00
IUUC-Laf-053702 Loxodonta africana 98.49 0.00e+00 794.00
IUUC-Mcc-054898 Macaca mulatta 99.46 0.00e+00 763.00
IUUC-Meu-056040 Macropus eugenii 70.99 2.00e-146 511.00
IUUC-Mga-059957 Meleagris gallopavo 86.80 1.00e-179 621.00
IUUC-Mdo-061837 Monodelphis domestica 92.66 0.00e+00 735.00
IUUC-Mmu-063790 Mus musculus 98.50 0.00e+00 798.00
IUUC-Mpu-066143 Mustela putorius furo 98.81 0.00e+00 694.00
IUUC-Mlu-067291 Myotis lucifugus 97.02 0.00e+00 657.00
IUUC-Nle-069370 Nomascus leucogenys 98.16 0.00e+00 778.00
IUUC-Opr-070433 Ochotona princeps 79.39 3.00e-179 620.00
IUUC-Ont-071771 Oreochromis niloticus 59.47 2.00e-115 409.00
IUUC-Oan-073414 Ornithorhynchus anatinus 93.12 1.00e-155 541.00
IUUC-Ocu-074318 Oryctolagus cuniculus 99.00 0.00e+00 826.00
IUUC-Ola-086879 Oryzias latipes 65.70 5.00e-114 404.00
IUUC-Oga-088211 Otolemur garnettii 97.75 0.00e+00 785.00
IUUC-Oar-089978 Ovis aries 98.48 0.00e+00 812.00
IUUC-Ptr-091586 Pan troglodytes 100.00 0.00e+00 835.00
IUUC-Psi-094023 Pelodiscus sinensis 85.06 0.00e+00 700.00
IUUC-Pab-098663 Pongo abelii 98.71 0.00e+00 763.00
IUUC-Pca-100960 Procavia capensis 96.73 0.00e+00 644.00
IUUC-Pva-102567 Pteropus vampyrus 95.78 0.00e+00 725.00
IUUC-Rno-104966 Rattus norvegicus 93.77 0.00e+00 654.00
IUUC-Sha-106505 Sarcophilus harrisii 94.20 7.00e-148 516.00
IUUC-Sja-107946 Schizosaccharomyces japonicus 42.19 3.00e-13 68.90
IUUC-Ssc-116294 Sus scrofa 99.63 1.00e-161 561.00
IUUC-Tgu-117464 Taeniopygia guttata 85.97 0.00e+00 701.00
IUUC-Tni-120175 Tetraodon nigroviridis 58.31 5.00e-112 397.00
IUUC-Tbe-128124 Tupaia belangeri 71.73 1.00e-135 476.00
IUUC-Ttr-128752 Tursiops truncatus 99.11 0.00e+00 689.00
IUUC-Vpa-130764 Vicugna pacos 88.69 4.00e-173 600.00
IUUC-Xtr-132343 Xenopus tropicalis 77.44 9.00e-179 619.00
Created Date 25-Jun-2017

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