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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046618
UUCD1 version UUC-HoS-00941
Ensembl Protein ID ENSP00000366902.4
UniProt Accession P10074; Q5SY19; TZAP_HUMAN
Genbank Protein ID AAA65124.1; AAB08973.1; AAB08973.1; CAI16079.1; AAH13573.1; AAA35989.1
Protein Name Telomere zinc finger-associated protein; Krueppel-related zinc finger protein 3; Zinc finger and BTB domain-containing protein 48; Zinc finger protein 855
Genbank Nucleotide ID L16896; U45325; U45324; AL591866; BC013573; M20677
Gene Name ZBTB48; HKR3; TZAP; ZNF855
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000204859.12 ENST00000377674.8 ENSP00000366902.4
ENSG00000204859.12 ENST00000466813.1 ENSP00000467104.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProt
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 1.20e-06 30.4 26 87
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +D +l vgg +f+ah +vLa +S++F++l      ++ s++ v++    +e f  ll+F Ytg l +
   Q: 26   CDATLDVGGLVFKAHWSVLACCSHFFQSLYG----DG-SGGSVVLPAGFAEIFGLLLDFFYTGHLAL 87
           89***************************94....45.4899*********************9976 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Telomere-binding protein that acts as a regulator of telomere length (PubMed:28082411). Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28082411). Preferentially binds to long telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411). Also acts as a transcription regulator that binds to promoter regions (PubMed:7969177, PubMed:24382891). Regulates expression the J and/or S elements in MHC II promoter (PubMed:7969177). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891).
 Telomere-binding protein that acts as a regulator of telomere length (PubMed:28082411). Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28082411). Preferentially binds to long telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411). Also acts as a transcription regulator that binds to promoter regions (PubMed:7969177, PubMed:24382891). Regulates expression the J and/or S elements in MHC II promoter (PubMed:7969177). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891).
Protein Sequence
(Fasta)
MDGSFVQHSV RVLQELNKQR EKGQYCDATL DVGGLVFKAH WSVLACCSHF FQSLYGDGSG 60
GSVVLPAGFA EIFGLLLDFF YTGHLALTSG NRDQVLLAAR ELRVPEAVEL CQSFKPKTSV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046618|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GACGTCACGT CCGGCGCGGA GACGGTGGAG TCTCCGCACT GTCGGCGGGG TACGCATAGC 60
CGGGCACTAG GTTCGTGGGC TGTGGAGGCG ACGGAGCAGG GGGCCAGTGG GGCCAGCTCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046618|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0779--Telomere
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0003691--F:double-stranded telomeric DNA binding
GO:0042802--F:identical protein binding
GO:0046872--F:metal ion binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0010833--P:telomere maintenance via telomere lengthening
GO:0006351--P:transcription, DNA-templated
KEGG hsa:3104
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001731 Ailuropoda melanoleuca 93.17 0.00e+00 1249.00
IUUC-Bta-012521 Bos taurus 92.59 0.00e+00 1231.00
IUUC-Cja-019221 Callithrix jacchus 90.35 0.00e+00 1190.00
IUUC-Cfa-020921 Canis familiaris 90.59 0.00e+00 1202.00
IUUC-Cpo-021758 Cavia porcellus 93.17 0.00e+00 1218.00
IUUC-Csa-023497 Chlorocebus sabaeus 98.11 0.00e+00 1328.00
IUUC-Dno-029919 Dasypus novemcinctus 89.39 0.00e+00 1197.00
IUUC-Dor-030586 Dipodomys ordii 90.12 0.00e+00 1209.00
IUUC-Ete-032430 Echinops telfairi 87.35 0.00e+00 1143.00
IUUC-Eca-033442 Equus caballus 93.60 0.00e+00 1229.00
IUUC-Eeu-034922 Erinaceus europaeus 86.24 0.00e+00 783.00
IUUC-Fca-035486 Felis catus 93.31 0.00e+00 1247.00
IUUC-Gmo-039194 Gadus morhua 54.29 2.00e-176 612.00
IUUC-Gga-040361 Gallus gallus 89.75 0.00e+00 727.00
IUUC-Ggo-045193 Gorilla gorilla 99.42 0.00e+00 1303.00
IUUC-Itr-048576 Ictidomys tridecemlineatus 94.48 0.00e+00 1251.00
IUUC-Lch-049869 Latimeria chalumnae 58.99 0.00e+00 800.00
IUUC-Laf-053873 Loxodonta africana 88.10 0.00e+00 1173.00
IUUC-Mcc-055703 Macaca mulatta 98.26 0.00e+00 1331.00
IUUC-Meu-056339 Macropus eugenii 79.74 0.00e+00 1061.00
IUUC-Mmr-061354 Microcebus murinus 96.37 0.00e+00 1286.00
IUUC-Mdo-062372 Monodelphis domestica 71.47 2.00e-141 496.00
IUUC-Mmu-063883 Mus musculus 90.84 0.00e+00 1251.00
IUUC-Mpu-066260 Mustela putorius furo 92.73 0.00e+00 1259.00
IUUC-Mlu-067675 Myotis lucifugus 84.91 0.00e+00 1034.00
IUUC-Nle-069672 Nomascus leucogenys 98.69 0.00e+00 1339.00
IUUC-Opr-070357 Ochotona princeps 87.50 0.00e+00 1159.00
IUUC-Oan-072874 Ornithorhynchus anatinus 78.70 0.00e+00 1026.00
IUUC-Ocu-073872 Oryctolagus cuniculus 91.86 0.00e+00 1231.00
IUUC-Oga-088469 Otolemur garnettii 94.77 0.00e+00 1311.00
IUUC-Oar-090081 Ovis aries 84.47 0.00e+00 1088.00
IUUC-Ptr-090537 Pan troglodytes 99.85 0.00e+00 1310.00
IUUC-Pan-092530 Papio anubis 98.26 0.00e+00 1331.00
IUUC-Psi-093837 Pelodiscus sinensis 73.68 0.00e+00 995.00
IUUC-Pab-097987 Pongo abelii 98.55 0.00e+00 1296.00
IUUC-Pca-100921 Procavia capensis 87.79 0.00e+00 1169.00
IUUC-Rno-105597 Rattus norvegicus 90.14 0.00e+00 1235.00
IUUC-Sha-107605 Sarcophilus harrisii 92.05 0.00e+00 663.00
IUUC-Sar-113191 Sorex araneus 61.88 6.00e-101 361.00
IUUC-Ssc-115656 Sus scrofa 93.78 0.00e+00 1262.00
IUUC-Tsy-119603 Tarsius syrichta 89.57 4.00e-107 382.00
IUUC-Tni-120741 Tetraodon nigroviridis 72.07 3.00e-144 505.00
IUUC-Ttr-129274 Tursiops truncatus 91.42 0.00e+00 1207.00
IUUC-Vpa-130774 Vicugna pacos 76.16 0.00e+00 922.00
Created Date 25-Jun-2017

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