iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-064134

UUCD1 version

UUC-MuM-00185

Ensembl Protein ID

ENSMUSP00000022890.8

UniProt Accession

P50636; Q3UGT2; Q9QUJ5; RN19A_MOUSE

Genbank Protein ID

AAF18302.1; AAF18303.1; BAE28125.1; AAH40769.1; AAK51469.1; AAG37798.1; CAA50643.1

Protein Name

E3 ubiquitin-protein ligase RNF19A; Double ring-finger protein; Gametogenesis-expressed protein GEG-154; RING finger protein 19A; UBCM4-interacting protein 117; XY body protein

Genbank Nucleotide ID

AF120206; AF120207; AK147768; BC040769; AF360999; AF071560; X71642

Gene Name

Rnf19a; Geg-154; Rnf19; Xybp

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000022280.8	ENSMUST00000022890.8	ENSMUSP00000022890.8

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RBR	1.00e-52	179.6	132	332

Active Site

Position(s)	Description	Evidence
316	N/A	{ECO:0000250\|UniProtKB:Q9Y4X5}

Domain Profile

E3 activity/RBR

   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpekleeseikellveeelykryekllleevveadaalkw 90
           C++Cll++s+++++ +++C+h+ C +Cl+qyl+++i+e++ ++iscp  ec+e++++++i+ +l+++ l+++ye+++l++++ ad++++w
   Q: 132  CPLCLLRHSKDRFPDIMTCHHRSCVDCLRQYLRIEISESR-VNISCP--ECTERFNPHDIRLILSDDVLMEKYEEFMLRRWLVADPDCRW 218
           ****************************************.9*****..89*************************************** PP
   S: 91   cpapdCslvvllekea..eklevecekcgkefCveCkeewHeglsCkelkeklakteeek.......eeaeskelleanskkCpkCkvyi 171
           cpapdC ++v++  +a  +kl++ +e+cg+efC++Ck++wH++++C+++++++a++ + +       + ++++ ++++++k+Cp+C +yi
   Q: 219  CPAPDCGYAVIAFGCAscPKLTCGREGCGTEFCYHCKQIWHPNQTCDAARQERAQSLRLRtirsssiSYSQESGAAADDIKPCPRCAAYI 308
           *************999889************************************99998999*99999999****************** PP
   S: 172  ek..negCnhmtCakCkaefCwlC 193
           +k  +++CnhmtCa C++efCwlC
   Q: 309  IKmnDGSCNHMTCAVCGCEFCWLC 332
           *997889***************** PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR.

Protein Sequence
(Fasta)

MQEQEISFIF KYNEGLCMNI DSDSILMSIL DMSLHQQMGS DRDLQSSTSS VSLPSVKKAP 60
KQRRISIGSL FRRKKDSKRK SRELNGGVDG IASIESIHSE MCADKNSIFS TNTSSDNGLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGGAGAAT GGCAGTTGCT GTGTTGGTTC CCGGCTGCGA CGGTCCGACT GGAGTCACAG 60
AGGGGAGTTC GGGAAAGCGG CCGCCCGCAA CCGTTCCACC GGCAGCTCTC GCCCTAGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF01485--IBR

SMART

SM00647--IBR
SM00184--RING

Gene Ontology

GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0016021--C:integral component of membrane
GO:0000151--C:ubiquitin ligase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

mmu:30945

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001958	Ailuropoda melanoleuca	93.57	0.00e+00	1347.00
IUUC-Apl-003427	Anas platyrhynchos	87.94	0.00e+00	1144.00
IUUC-Aca-004252	Anolis carolinensis	85.07	0.00e+00	1115.00
IUUC-Ame-011434	Astyanax mexicanus	78.85	0.00e+00	883.00
IUUC-Bta-013558	Bos taurus	93.45	0.00e+00	1348.00
IUUC-Cel-018626	Caenorhabditis elegans	55.49	1.00e-111	397.00
IUUC-Cja-019070	Callithrix jacchus	93.81	0.00e+00	1346.00
IUUC-Cfa-020286	Canis familiaris	93.10	0.00e+00	1340.00
IUUC-Cpo-022015	Cavia porcellus	92.50	0.00e+00	1318.00
IUUC-Csa-023975	Chlorocebus sabaeus	93.57	0.00e+00	1315.00
IUUC-Cho-024442	Choloepus hoffmanni	78.69	0.00e+00	1123.00
IUUC-Cin-025143	Ciona intestinalis	55.41	2.00e-43	168.00
IUUC-Dre-028422	Danio rerio	73.56	0.00e+00	879.00
IUUC-Dno-029018	Dasypus novemcinctus	92.64	0.00e+00	1248.00
IUUC-Dor-030548	Dipodomys ordii	87.36	9.00e-175	607.00
IUUC-Eca-034249	Equus caballus	93.68	0.00e+00	1348.00
IUUC-Eeu-035298	Erinaceus europaeus	96.52	0.00e+00	834.00
IUUC-Fca-035912	Felis catus	92.98	0.00e+00	1339.00
IUUC-Fal-037488	Ficedula albicollis	84.62	0.00e+00	1108.00
IUUC-Gmo-038893	Gadus morhua	82.06	0.00e+00	811.00
IUUC-Gga-040380	Gallus gallus	87.02	0.00e+00	1109.00
IUUC-Gac-041421	Gasterosteus aculeatus	73.69	0.00e+00	884.00
IUUC-Ggo-044893	Gorilla gorilla	93.69	0.00e+00	1342.00
IUUC-Hsa-046876	Homo sapiens	93.57	0.00e+00	1339.00
IUUC-Itr-048257	Ictidomys tridecemlineatus	93.93	0.00e+00	1347.00
IUUC-Lch-049774	Latimeria chalumnae	83.70	0.00e+00	1100.00
IUUC-Loc-052040	Lepisosteus oculatus	77.28	0.00e+00	988.00
IUUC-Laf-053874	Loxodonta africana	92.98	0.00e+00	1306.00
IUUC-Mcc-054817	Macaca mulatta	95.11	9.00e-109	385.00
IUUC-Meu-056648	Macropus eugenii	89.32	4.00e-173	602.00
IUUC-Mga-060175	Meleagris gallopavo	85.99	0.00e+00	1135.00
IUUC-Mmr-060800	Microcebus murinus	93.93	0.00e+00	1349.00
IUUC-Mdo-061827	Monodelphis domestica	85.17	0.00e+00	1101.00
IUUC-Mpu-066076	Mustela putorius furo	93.10	0.00e+00	1336.00
IUUC-Mlu-068218	Myotis lucifugus	92.62	0.00e+00	1264.00
IUUC-Nle-069707	Nomascus leucogenys	96.18	0.00e+00	1081.00
IUUC-Opr-070977	Ochotona princeps	92.83	0.00e+00	1329.00
IUUC-Ont-072373	Oreochromis niloticus	78.67	0.00e+00	931.00
IUUC-Oan-073376	Ornithorhynchus anatinus	86.36	1.00e-163	569.00
IUUC-Ocu-074878	Oryctolagus cuniculus	91.90	0.00e+00	1290.00
IUUC-Ola-086472	Oryzias latipes	78.41	0.00e+00	932.00
IUUC-Oga-088377	Otolemur garnettii	93.43	0.00e+00	1331.00
IUUC-Oar-089540	Ovis aries	93.10	0.00e+00	1341.00
IUUC-Ptr-090613	Pan troglodytes	93.57	0.00e+00	1339.00
IUUC-Pan-092879	Papio anubis	93.57	0.00e+00	1318.00
IUUC-Psi-093201	Pelodiscus sinensis	87.27	0.00e+00	1098.00
IUUC-Pma-094620	Petromyzon marinus	70.40	0.00e+00	815.00
IUUC-Pfo-096615	Poecilia formosa	83.52	0.00e+00	891.00
IUUC-Pca-100625	Procavia capensis	91.40	0.00e+00	1303.00
IUUC-Pva-103110	Pteropus vampyrus	85.60	0.00e+00	1061.00
IUUC-Rno-105998	Rattus norvegicus	96.43	0.00e+00	1352.00
IUUC-Sha-107523	Sarcophilus harrisii	84.90	0.00e+00	1107.00
IUUC-Sar-113089	Sorex araneus	90.41	0.00e+00	922.00
IUUC-Ssc-115471	Sus scrofa	92.74	0.00e+00	1300.00
IUUC-Tgu-117080	Taeniopygia guttata	86.44	0.00e+00	1149.00
IUUC-Tru-117547	Takifugu rubripes	78.82	0.00e+00	884.00
IUUC-Tsy-119143	Tarsius syrichta	93.57	0.00e+00	1337.00
IUUC-Tni-119693	Tetraodon nigroviridis	77.23	0.00e+00	878.00
IUUC-Ttr-129175	Tursiops truncatus	92.62	0.00e+00	1317.00
IUUC-Vpa-130594	Vicugna pacos	86.61	0.00e+00	1241.00
IUUC-Xtr-132579	Xenopus tropicalis	86.18	0.00e+00	1117.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence