iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	dbPTM	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.10e-30	103.6	156	208

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           +vq+lyd+ +q+++eL +++Gdv++v   +  de+W++g  e  +++G+fP+ +v+ 
   Q: 156  LVQALYDFVPQESGELDFRRGDVITVT--DRSDENWWNG--EIGNRKGIFPATYVTP 208
           79************************7..9*********..9************985 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Required for proper signaling by sevenless. May act to stimulate the ability of Sos to catalyze Ras1 activation by linking sevenless and Sos in a signaling complex.

Protein Sequence
(Fasta)

MEAIAKHDFS ATADDELSFR KTQILKILNM EDDSNWYRAE LDGKEGLIPS NYIEMKNHDW 60
YYGRITRADA EKLLSNKHEG AFLIRISESS PGDFSLSVKC PDGVQHFKVL RDAQSKFFLW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCTTGGAAT AATAAAGCGA CCCGGCCACG GTCACGCTGC TATGAAAATA AAAGTGAATT 60
ACAAATTTAG CAGTAGTAAT ATGTTAGCCA AACCGCTCCC GCGCCTAATT AGTGTCGCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0807--Transducer

Interpro

IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005118--F:sevenless binding
GO:0005070--F:SH3/SH2 adaptor activity
GO:0004871--F:signal transducer activity
GO:0007015--P:actin filament organization
GO:0007256--P:activation of JNKK activity
GO:0008595--P:anterior/posterior axis specification, embryo
GO:0008306--P:associative learning
GO:0016477--P:cell migration
GO:0001700--P:embryonic development via the syncytial blastoderm
GO:0007476--P:imaginal disc-derived wing morphogenesis
GO:0045087--P:innate immune response
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0008355--P:olfactory learning
GO:0030707--P:ovarian follicle cell development
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0043410--P:positive regulation of MAPK cascade
GO:0045678--P:positive regulation of R7 cell differentiation
GO:0007265--P:Ras protein signal transduction
GO:0042127--P:regulation of cell proliferation
GO:0008360--P:regulation of cell shape
GO:0045500--P:sevenless signaling pathway
GO:0007614--P:short-term memory
GO:0038202--P:TORC1 signaling
GO:0008293--P:torso signaling pathway

KEGG

dme:Dmel_CG6033

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001345	Ailuropoda melanoleuca	63.64	6.00e-67	245.00
IUUC-Apl-003322	Anas platyrhynchos	63.44	2.00e-66	244.00
IUUC-Aca-005193	Anolis carolinensis	64.62	4.00e-78	283.00
IUUC-Ame-010929	Astyanax mexicanus	64.62	2.00e-78	283.00
IUUC-Bgr-012270	Blumeria graminis	56.00	2.00e-11	62.80
IUUC-Bta-012932	Bos taurus	65.57	1.00e-78	285.00
IUUC-Cel-018665	Caenorhabditis elegans	61.03	1.00e-76	278.00
IUUC-Cja-019225	Callithrix jacchus	65.57	1.00e-78	285.00
IUUC-Cfa-020887	Canis familiaris	65.57	1.00e-78	285.00
IUUC-Cpo-022488	Cavia porcellus	65.57	1.00e-78	285.00
IUUC-Csa-023326	Chlorocebus sabaeus	65.57	1.00e-78	285.00
IUUC-Cho-024953	Choloepus hoffmanni	53.55	1.00e-55	207.00
IUUC-Cin-025144	Ciona intestinalis	61.93	1.00e-74	271.00
IUUC-Csv-026210	Ciona savignyi	60.58	1.00e-73	268.00
IUUC-Dre-028403	Danio rerio	66.04	6.00e-79	285.00
IUUC-Dno-029187	Dasypus novemcinctus	65.09	9.00e-78	281.00
IUUC-Dor-030763	Dipodomys ordii	65.57	1.00e-78	285.00
IUUC-Ete-032354	Echinops telfairi	46.70	6.00e-46	176.00
IUUC-Eca-033222	Equus caballus	65.57	1.00e-78	285.00
IUUC-Eeu-034513	Erinaceus europaeus	69.70	9.00e-37	145.00
IUUC-Fca-036294	Felis catus	65.57	1.00e-78	285.00
IUUC-Fal-037130	Ficedula albicollis	64.62	1.00e-77	281.00
IUUC-Gmo-039546	Gadus morhua	64.15	4.00e-77	280.00
IUUC-Gga-041139	Gallus gallus	65.09	2.00e-78	283.00
IUUC-Gac-041968	Gasterosteus aculeatus	64.15	7.00e-78	282.00
IUUC-Ggo-044562	Gorilla gorilla	65.57	1.00e-78	285.00
IUUC-Hsa-046730	Homo sapiens	65.57	1.00e-78	285.00
IUUC-Itr-049025	Ictidomys tridecemlineatus	65.57	1.00e-78	285.00
IUUC-Lch-050230	Latimeria chalumnae	63.12	5.00e-48	183.00
IUUC-Loc-052723	Lepisosteus oculatus	64.15	7.00e-78	282.00
IUUC-Laf-053774	Loxodonta africana	65.09	7.00e-78	282.00
IUUC-Mcc-054603	Macaca mulatta	65.57	1.00e-78	285.00
IUUC-Meu-056173	Macropus eugenii	53.30	2.00e-58	217.00
IUUC-Mga-059950	Meleagris gallopavo	65.09	2.00e-78	283.00
IUUC-Mmr-060878	Microcebus murinus	65.57	1.00e-78	285.00
IUUC-Mdo-062454	Monodelphis domestica	65.09	3.00e-78	283.00
IUUC-Mmu-063913	Mus musculus	65.57	2.00e-78	284.00
IUUC-Mpu-066125	Mustela putorius furo	65.57	1.00e-78	285.00
IUUC-Mlu-068007	Myotis lucifugus	65.57	1.00e-78	285.00
IUUC-Nle-069101	Nomascus leucogenys	65.57	1.00e-78	285.00
IUUC-Opr-071075	Ochotona princeps	65.57	1.00e-78	285.00
IUUC-Ont-072253	Oreochromis niloticus	64.15	6.00e-77	279.00
IUUC-Oan-073107	Ornithorhynchus anatinus	44.44	2.00e-47	181.00
IUUC-Ocu-074583	Oryctolagus cuniculus	65.57	1.00e-78	285.00
IUUC-Ola-086586	Oryzias latipes	67.55	8.00e-58	216.00
IUUC-Oga-089047	Otolemur garnettii	65.57	1.00e-78	285.00
IUUC-Oar-089904	Ovis aries	60.85	1.00e-70	258.00
IUUC-Ptr-090678	Pan troglodytes	65.57	1.00e-78	285.00
IUUC-Pan-092090	Papio anubis	65.57	1.00e-78	285.00
IUUC-Psi-093765	Pelodiscus sinensis	65.09	3.00e-78	283.00
IUUC-Pma-094650	Petromyzon marinus	62.74	5.00e-76	276.00
IUUC-Pfo-096131	Poecilia formosa	64.62	4.00e-78	283.00
IUUC-Pab-098709	Pongo abelii	65.57	1.00e-78	285.00
IUUC-Pca-100581	Procavia capensis	63.44	3.00e-66	243.00
IUUC-Pva-103066	Pteropus vampyrus	65.57	1.00e-78	285.00
IUUC-Rno-105224	Rattus norvegicus	65.57	1.00e-78	285.00
IUUC-Sce-106264	Saccharomyces cerevisiae	56.00	7.00e-12	64.30
IUUC-Sha-107247	Sarcophilus harrisii	63.44	2.00e-66	243.00
IUUC-Sar-113277	Sorex araneus	55.19	4.00e-60	223.00
IUUC-Ssc-115478	Sus scrofa	65.57	1.00e-78	285.00
IUUC-Tgu-117479	Taeniopygia guttata	64.62	1.00e-77	281.00
IUUC-Tru-118451	Takifugu rubripes	60.71	2.00e-68	251.00
IUUC-Tsy-119029	Tarsius syrichta	64.15	1.00e-53	201.00
IUUC-Tni-120563	Tetraodon nigroviridis	45.87	8.00e-49	185.00
IUUC-Tbe-128097	Tupaia belangeri	65.57	4.00e-78	282.00
IUUC-Ttr-128195	Tursiops truncatus	54.17	2.00e-63	234.00
IUUC-Vpa-130754	Vicugna pacos	65.57	1.00e-78	285.00
IUUC-Xtr-132275	Xenopus tropicalis	60.71	1.00e-76	278.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence