iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-107159

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01179865

Gene Name

AIRE

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000003809.1	ENSSHAT00000004371.1	ENSSHAP00000004327.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	5.10e-11	42.7	296	338

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkC 51
            C+vC++gge    l++C+ C ++fH aCl+++  +e p+   w C  C
   Q: 296  ECAVCRDGGE----LICCDGCPRAFHLACLEPP-LTEIPSGM-WRCGCC 338
           6*********....*******************.*******7.****99 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

RPSGETDVRQ LLKLYRTEIS MAVDDTFPLL HGLADHDVIT EDKFRETQSL GEKDGCHKAL 60
HALLSWLLGR DSASIRAFWA VLFKDYNLER YGRLQAIHSS FPKDVDLSRG HKGRRPPASL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGACCCTCAG GGGAGACAGA CGTCCGGCAG CTGCTGAAAC TCTACCGAAC CGAGATCTCC 60
ATGGCGGTGG ACGACACTTT CCCGTTGCTC CATGGCCTGG CCGATCATGA CGTCATCACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008087--AIRE
IPR004865--HSR_dom
IPR000770--SAND_dom
IPR010919--SAND_dom-like
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51414--HSR
PS50864--SAND
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF03172--HSR
PF00628--PHD

PRINTS

PR01711--AIREGULATOR

SMART

SM00249--PHD

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0003682--F:chromatin binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0045182--F:translation regulator activity
GO:0008270--F:zinc ion binding
GO:0002509--P:central tolerance induction to self antigen
GO:0032602--P:chemokine production
GO:0006959--P:humoral immune response
GO:0045060--P:negative thymic T cell selection
GO:0002458--P:peripheral T cell tolerance induction
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000410--P:regulation of thymocyte migration
GO:0097536--P:thymus epithelium morphogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001612	Ailuropoda melanoleuca	47.49	3.00e-109	389.00
IUUC-Aca-004543	Anolis carolinensis	62.90	1.00e-21	93.60
IUUC-Bta-012988	Bos taurus	49.54	3.00e-117	415.00
IUUC-Bdi-014663	Brachypodium distachyon	59.57	9.00e-13	69.70
IUUC-Cja-019486	Callithrix jacchus	45.48	4.00e-64	238.00
IUUC-Cfa-021069	Canis familiaris	49.46	2.00e-110	392.00
IUUC-Cpo-021649	Cavia porcellus	46.83	1.00e-100	360.00
IUUC-Csa-023960	Chlorocebus sabaeus	48.97	3.00e-100	358.00
IUUC-Cne-026966	Cryptococcus neoformans	56.86	2.00e-11	63.90
IUUC-Dre-028583	Danio rerio	35.10	1.00e-71	263.00
IUUC-Dno-029869	Dasypus novemcinctus	44.37	2.00e-85	309.00
IUUC-Dor-030263	Dipodomys ordii	63.74	5.00e-31	127.00
IUUC-Ete-032778	Echinops telfairi	67.29	2.00e-39	156.00
IUUC-Eca-034328	Equus caballus	47.46	8.00e-106	377.00
IUUC-Fca-035400	Felis catus	46.10	2.00e-105	376.00
IUUC-Fal-036644	Ficedula albicollis	46.69	2.00e-75	276.00
IUUC-Fox-038014	Fusarium oxysporum	36.00	3.00e-08	54.30
IUUC-Fso-038262	Fusarium solani	38.00	2.00e-08	55.10
IUUC-Ggo-045250	Gorilla gorilla	49.81	2.00e-113	402.00
IUUC-Hsa-046603	Homo sapiens	49.05	1.00e-110	393.00
IUUC-Hvu-047073	Hordeum vulgare	54.39	5.00e-14	73.60
IUUC-Itr-048977	Ictidomys tridecemlineatus	47.30	1.00e-117	416.00
IUUC-Lch-050310	Latimeria chalumnae	38.39	1.00e-91	330.00
IUUC-Loc-052508	Lepisosteus oculatus	37.12	1.00e-93	337.00
IUUC-Lma-053053	Leptosphaeria maculans	51.06	2.00e-12	68.20
IUUC-Laf-054028	Loxodonta africana	53.33	3.00e-84	305.00
IUUC-Mcc-054935	Macaca mulatta	49.06	2.00e-111	395.00
IUUC-Mga-059318	Meleagris gallopavo	40.85	1.00e-56	213.00
IUUC-Mmr-061557	Microcebus murinus	42.00	3.00e-89	322.00
IUUC-Mdo-062475	Monodelphis domestica	76.01	0.00e+00	753.00
IUUC-Mmu-063994	Mus musculus	47.70	1.00e-125	443.00
IUUC-Mpu-066347	Mustela putorius furo	46.81	2.00e-118	419.00
IUUC-Mlu-068239	Myotis lucifugus	42.90	2.00e-51	196.00
IUUC-Nle-069544	Nomascus leucogenys	78.57	2.00e-22	99.00
IUUC-Opr-071199	Ochotona princeps	47.57	2.00e-46	180.00
IUUC-Ont-072571	Oreochromis niloticus	32.05	2.00e-55	209.00
IUUC-Oan-073739	Ornithorhynchus anatinus	57.89	3.00e-163	568.00
IUUC-Ogl-077865	Oryza glaberrima	60.87	4.00e-13	70.50
IUUC-Olo-080499	Oryza longistaminata	60.87	4.00e-13	71.20
IUUC-Opu-083209	Oryza punctata	60.87	5.00e-13	70.90
IUUC-Ola-086528	Oryzias latipes	35.26	9.00e-45	174.00
IUUC-Oga-088353	Otolemur garnettii	52.05	3.00e-123	435.00
IUUC-Oar-090065	Ovis aries	52.20	2.00e-93	335.00
IUUC-Ptr-091347	Pan troglodytes	48.30	2.00e-107	382.00
IUUC-Pan-092423	Papio anubis	48.82	5.00e-109	388.00
IUUC-Psi-093798	Pelodiscus sinensis	51.85	2.00e-137	482.00
IUUC-Pfo-096145	Poecilia formosa	38.46	1.00e-37	150.00
IUUC-Pab-098369	Pongo abelii	55.79	7.00e-79	287.00
IUUC-Pca-100537	Procavia capensis	45.83	1.00e-106	379.00
IUUC-Ppe-101215	Prunus persica	58.33	5.00e-13	69.70
IUUC-Pva-102639	Pteropus vampyrus	49.35	3.00e-108	385.00
IUUC-Pte-104185	Pyrenophora teres	29.94	3.00e-15	78.20
IUUC-Pyt-104775	Pyrenophora triticirepentis	32.02	1.00e-15	79.00
IUUC-Rno-105285	Rattus norvegicus	50.74	1.00e-128	452.00
IUUC-Sit-110355	Setaria italica	56.25	1.00e-11	66.20
IUUC-Sbi-113930	Sorghum bicolor	56.25	9.00e-12	66.20
IUUC-Ssc-115773	Sus scrofa	47.53	1.00e-115	409.00
IUUC-Tgu-116922	Taeniopygia guttata	46.15	3.00e-74	271.00
IUUC-Tru-118263	Takifugu rubripes	36.78	3.00e-39	155.00
IUUC-Tsy-119270	Tarsius syrichta	53.60	2.00e-60	226.00
IUUC-Tni-120138	Tetraodon nigroviridis	31.86	2.00e-65	243.00
IUUC-Tca-121757	Theobroma cacao	53.57	4.00e-13	71.20
IUUC-Tre-121959	Trichoderma reesei	39.58	5.00e-09	57.00
IUUC-Tvi-122553	Trichoderma virens	27.45	4.00e-09	57.40
IUUC-Tae-124715	Triticum aestivum	63.04	7.00e-14	73.60
IUUC-Tme-127204	Tuber melanosporum	55.32	1.00e-13	72.40
IUUC-Tbe-128077	Tupaia belangeri	46.30	3.00e-112	399.00
IUUC-Ttr-128781	Tursiops truncatus	52.94	5.00e-43	168.00
IUUC-Xma-133054	Xiphophorus maculatus	31.77	3.00e-64	239.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence