iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-064165

UUCD1 version

UUC-MuM-00498

Ensembl Protein ID

ENSMUSP00000113283.1

UniProt Accession

Q6I6G8; Q3KNL8; Q6ZPU4; Q8C956; HECW2_MOUSE

Genbank Protein ID

BAD23960.1; BAC31406.1; AAI07220.1; BAC98135.1

Protein Name

E3 ubiquitin-protein ligase HECW2; HECT, C2 and WW domain-containing protein 2; HECT-type E3 ubiquitin transferase HECW2; NEDD4-like E3 ubiquitin-protein ligase 2

Genbank Nucleotide ID

AB182244; AK042922; BC107219; AK129325

Gene Name

Hecw2; Kiaa1301; Nedl2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000042807.15	ENSMUST00000120904.7	ENSMUSP00000113283.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	circBase	miRTarBase	microRNA
TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-121	407.2	1246	1578

Active Site

Position(s)	Description	Evidence
1546	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1246 DLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1331
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+  ++l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLkpgG+nipVt++Nk+eY+++
   Q: 1332 AFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDN---DIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIER 1414
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1415 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1501
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ + lP+++TCfn+L+LP+Y+s + l+ekLl+A+eet+ F+l+
   Q: 1502 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1578
           **************************************************************************985 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. Involved in the regulation of mitotic metaphase/anaphase transition.

Protein Sequence
(Fasta)

MASSAREHLL FVRRRNPQMR YTLSPENLQS LAAQNSMPEN MALQRANSDT DLVTSESRSS 60
LTASMYEYTL GQAQNLIIFW DIKEEVDPSD WIGLYHIDEN SPANFWDSKN RGVTGTQKGQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTCTGGAGC GCCGTCCCCA GGGAGGTCCC GTGGGCCCGG GTCTGGCCGC TTCTCCCCAG 60
CTCTGCTCGG TCAAGCTCCC GAGTACCCGA CGTGCAGGCG GCCCCCCGCC CAGCGCCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0072686--C:mitotic spindle
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030071--P:regulation of mitotic metaphase/anaphase transition

KEGG

mmu:329152

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	94.24	0.00e+00	2899.00
IUUC-Apl-003935	Anas platyrhynchos	83.85	0.00e+00	2674.00
IUUC-Aca-004558	Anolis carolinensis	82.61	0.00e+00	2608.00
IUUC-Ame-010893	Astyanax mexicanus	88.33	0.00e+00	1304.00
IUUC-Bta-013093	Bos taurus	96.22	0.00e+00	1578.00
IUUC-Cja-019651	Callithrix jacchus	93.00	0.00e+00	2791.00
IUUC-Cfa-021232	Canis familiaris	99.12	0.00e+00	1626.00
IUUC-Cpo-021770	Cavia porcellus	89.46	0.00e+00	2795.00
IUUC-Csa-023970	Chlorocebus sabaeus	94.24	0.00e+00	2894.00
IUUC-Cho-024512	Choloepus hoffmanni	86.57	0.00e+00	2583.00
IUUC-Csv-026127	Ciona savignyi	72.55	1.00e-155	543.00
IUUC-Dre-028275	Danio rerio	84.96	0.00e+00	1476.00
IUUC-Dno-029963	Dasypus novemcinctus	93.14	0.00e+00	2735.00
IUUC-Dor-030282	Dipodomys ordii	88.74	0.00e+00	1967.00
IUUC-Dme-032217	Drosophila melanogaster	72.11	0.00e+00	661.00
IUUC-Ete-033132	Echinops telfairi	82.91	0.00e+00	1260.00
IUUC-Eca-033978	Equus caballus	93.86	0.00e+00	2877.00
IUUC-Eeu-035278	Erinaceus europaeus	63.60	0.00e+00	1158.00
IUUC-Fca-036157	Felis catus	94.24	0.00e+00	2883.00
IUUC-Fal-037110	Ficedula albicollis	96.81	0.00e+00	1644.00
IUUC-Gmo-039291	Gadus morhua	80.31	0.00e+00	1019.00
IUUC-Gga-040821	Gallus gallus	84.52	0.00e+00	2671.00
IUUC-Gac-042456	Gasterosteus aculeatus	64.75	0.00e+00	1899.00
IUUC-Ggo-044862	Gorilla gorilla	94.20	0.00e+00	2787.00
IUUC-Hsa-046219	Homo sapiens	94.43	0.00e+00	2943.00
IUUC-Lch-050526	Latimeria chalumnae	77.53	0.00e+00	2410.00
IUUC-Loc-052648	Lepisosteus oculatus	87.46	0.00e+00	1520.00
IUUC-Laf-054005	Loxodonta africana	93.79	0.00e+00	2918.00
IUUC-Mcc-055314	Macaca mulatta	94.36	0.00e+00	2887.00
IUUC-Meu-056356	Macropus eugenii	67.55	0.00e+00	1098.00
IUUC-Mga-060074	Meleagris gallopavo	83.69	0.00e+00	2565.00
IUUC-Mmr-061526	Microcebus murinus	94.30	0.00e+00	2883.00
IUUC-Mdo-063017	Monodelphis domestica	90.33	0.00e+00	2765.00
IUUC-Mpu-065835	Mustela putorius furo	94.64	0.00e+00	1553.00
IUUC-Mlu-067709	Myotis lucifugus	89.62	0.00e+00	2733.00
IUUC-Nle-069308	Nomascus leucogenys	94.17	0.00e+00	2910.00
IUUC-Opr-070330	Ochotona princeps	81.00	0.00e+00	2372.00
IUUC-Ont-071345	Oreochromis niloticus	87.42	0.00e+00	1451.00
IUUC-Ocu-074775	Oryctolagus cuniculus	93.16	0.00e+00	2607.00
IUUC-Ola-087225	Oryzias latipes	63.99	0.00e+00	1831.00
IUUC-Oga-088177	Otolemur garnettii	92.35	0.00e+00	2764.00
IUUC-Oar-089452	Ovis aries	93.54	0.00e+00	2886.00
IUUC-Ptr-090806	Pan troglodytes	94.49	0.00e+00	2926.00
IUUC-Pan-091838	Papio anubis	94.13	0.00e+00	2773.00
IUUC-Psi-094090	Pelodiscus sinensis	84.76	0.00e+00	2671.00
IUUC-Pfo-096520	Poecilia formosa	68.06	0.00e+00	1511.00
IUUC-Pab-098405	Pongo abelii	94.36	0.00e+00	2912.00
IUUC-Pca-100441	Procavia capensis	87.67	0.00e+00	2219.00
IUUC-Pva-102324	Pteropus vampyrus	98.74	0.00e+00	1622.00
IUUC-Rno-105943	Rattus norvegicus	98.10	0.00e+00	3086.00
IUUC-Sha-106985	Sarcophilus harrisii	87.33	0.00e+00	2310.00
IUUC-Sar-113505	Sorex araneus	95.20	0.00e+00	1536.00
IUUC-Ssc-115439	Sus scrofa	93.12	0.00e+00	1912.00
IUUC-Tgu-117078	Taeniopygia guttata	89.76	0.00e+00	1759.00
IUUC-Tru-118671	Takifugu rubripes	83.35	0.00e+00	1442.00
IUUC-Tni-120069	Tetraodon nigroviridis	74.68	0.00e+00	1347.00
IUUC-Tbe-127975	Tupaia belangeri	91.94	0.00e+00	2415.00
IUUC-Ttr-128469	Tursiops truncatus	88.79	0.00e+00	2612.00
IUUC-Vpa-130498	Vicugna pacos	84.32	0.00e+00	2392.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence