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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046743
UUCD1 version UUC-HoS-01114
Ensembl Protein ID ENSP00000377797.2
UniProt Accession Q70CQ1; Q5T3D9; Q5T3E0; Q96CK4; UBP49_HUMAN
Genbank Protein ID CAE51939.1; CAI13187.1; CAI13188.1; EAX04065.1; AAH14176.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 49; Deubiquitinating enzyme 49; Ubiquitin thioesterase 49; Ubiquitin-specific-processing protease 49
Genbank Nucleotide ID AJ586139; AL365205; AL365205; CH471081; BC014176
Gene Name USP49
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000164663.14 ENST00000394253.7 ENSP00000377797.2
ENSG00000164663.14 ENST00000373010.5 ENSP00000362101.1
ENSG00000164663.14 ENST00000448078.1 ENSP00000389842.1
ENSG00000164663.14 ENST00000373006.5 ENSP00000362097.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanmiRecords
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 14715245
Classification
Family E-value Score Start End
DUB/USP 1.70e-97 328.3 253 656
Active Site
Position(s) Description Evidence
262 Nucleophile ECO:0000305}
615 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp.................................................. 42
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+ +++k+++  p                                                  
   Q: 253  TGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPkatngktqlsgkptnssatelslrndraeaceregfcwngrasisrslel 344
           7******************************7777777777777777888999999999999999999999999999999999999999999 PP
   S: 43   ......kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsd 128
                 ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ ll+++++el         e+e+++++ l  
   Q: 345  iqnkepSSKHISLCRELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQEL---------ESEGTTRRILIP 427
           99999989999************************************************************.........668888899999 PP
   S: 129  eaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..........slqdcLesftkeeelegenkyycek 210
            +++k +k+  ++++++F+gql sq++c +c+ +s++ epf+dlsl++p++ ++ ++           l+++L++ft++e leg+  y c++
   Q: 428  FSQRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYHCIEKgfvplnqtecLLTEMLAKFTETEALEGRI-YACDQ 518
           9***************************************************998879*************************965.***** PP
   S: 211  ckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kkkYeLiavvvHsG. 288
           c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c+++  ++ +  +  Y+L+avv+H+G 
   Q: 519  CNSKRRksnpkplvlseARKQLMIYRLPQVLRLHLKRFRWSGR-NHREKIGVHVVFDQVLTMEPYCCRDMLSSLDkeTFAYDLSAVVMHHGk 609
           **9999999*******************************997.8889********************876654433999************ PP
   S: 289  slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           +++sGHY+ay++n++g+ W++++Dsk ++++ eev++   ++aY+lfY++
   Q: 610  GFGSGHYTAYCYNTEGGfWVHCNDSKLNVCSVEEVCK---TQAYILFYTQ 656
           *************9999********************...********98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons.
 Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons.
Protein Sequence
(Fasta)
MDRCKHVGRL RLAQDHSILN PQKWCCLECA TTESVWACLK CSHVACGRYI EDHALKHFEE 60
TGHPLAMEVR DLYVFCYLCK DYVLNDNPEG DLKLLRSSLL AVRGQKQDTP VRRGRTLRSM 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046743|DUB,USP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCGCCCTGG TGACAGCTCG CGCGTGCTGA TGATGGCGGT AAATAGAGGG GGCCGGGGGA 60
GGGGACGGAG GAGGTGGGGA GGCAGCAAAG TGGGTAGCTC CAGGGGGTAG GGGGAACGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046743|DUB,USP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00443--UCH
PF02148--zf-UBP
SMART

SM00290--ZnF_UBP
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0004197--F:cysteine-type endopeptidase activity
GO:0042393--F:histone binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0000398--P:mRNA splicing, via spliceosome
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:25862
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002395 Ailuropoda melanoleuca 95.07 0.00e+00 846.00
IUUC-Apl-003658 Anas platyrhynchos 79.31 0.00e+00 1059.00
IUUC-Aca-005278 Anolis carolinensis 80.46 0.00e+00 1086.00
IUUC-Bta-012911 Bos taurus 90.55 0.00e+00 1144.00
IUUC-Cja-019171 Callithrix jacchus 96.95 0.00e+00 1284.00
IUUC-Cfa-020408 Canis familiaris 91.27 0.00e+00 1189.00
IUUC-Cpo-022233 Cavia porcellus 83.98 0.00e+00 1080.00
IUUC-Csa-024272 Chlorocebus sabaeus 97.92 0.00e+00 1065.00
IUUC-Cho-025051 Choloepus hoffmanni 90.00 0.00e+00 650.00
IUUC-Cin-025587 Ciona intestinalis 47.94 1.00e-105 377.00
IUUC-Dno-029856 Dasypus novemcinctus 91.27 0.00e+00 1197.00
IUUC-Ete-032761 Echinops telfairi 75.72 0.00e+00 863.00
IUUC-Eca-033851 Equus caballus 84.35 0.00e+00 1017.00
IUUC-Fca-035919 Felis catus 94.50 0.00e+00 791.00
IUUC-Fal-037290 Ficedula albicollis 77.15 0.00e+00 951.00
IUUC-Gmo-039249 Gadus morhua 77.36 2.00e-145 509.00
IUUC-Gac-042595 Gasterosteus aculeatus 59.94 0.00e+00 756.00
IUUC-Ggo-044979 Gorilla gorilla 99.56 0.00e+00 1322.00
IUUC-Itr-048251 Ictidomys tridecemlineatus 92.58 0.00e+00 1236.00
IUUC-Lch-050294 Latimeria chalumnae 75.79 0.00e+00 962.00
IUUC-Loc-051961 Lepisosteus oculatus 68.62 0.00e+00 815.00
IUUC-Laf-053819 Loxodonta africana 94.38 0.00e+00 847.00
IUUC-Mcc-055048 Macaca mulatta 98.40 0.00e+00 1305.00
IUUC-Meu-055971 Macropus eugenii 67.76 7.00e-150 524.00
IUUC-Mmr-061253 Microcebus murinus 79.11 3.00e-157 548.00
IUUC-Mdo-062073 Monodelphis domestica 82.90 0.00e+00 1103.00
IUUC-Mmu-064095 Mus musculus 90.54 0.00e+00 1202.00
IUUC-Mpu-066318 Mustela putorius furo 94.50 0.00e+00 862.00
IUUC-Mlu-067090 Myotis lucifugus 88.36 0.00e+00 1155.00
IUUC-Nle-069486 Nomascus leucogenys 99.27 0.00e+00 1320.00
IUUC-Opr-070563 Ochotona princeps 91.45 0.00e+00 1219.00
IUUC-Oan-073245 Ornithorhynchus anatinus 89.97 0.00e+00 627.00
IUUC-Ocu-074851 Oryctolagus cuniculus 90.43 0.00e+00 959.00
IUUC-Ola-086413 Oryzias latipes 58.10 0.00e+00 707.00
IUUC-Oga-088862 Otolemur garnettii 93.30 0.00e+00 1224.00
IUUC-Oar-089462 Ovis aries 89.93 0.00e+00 802.00
IUUC-Ptr-091525 Pan troglodytes 99.84 0.00e+00 1195.00
IUUC-Pan-092363 Papio anubis 98.34 0.00e+00 1249.00
IUUC-Psi-093353 Pelodiscus sinensis 81.64 0.00e+00 1082.00
IUUC-Pma-094155 Petromyzon marinus 59.39 7.00e-84 303.00
IUUC-Pfo-096413 Poecilia formosa 61.16 0.00e+00 782.00
IUUC-Pab-098592 Pongo abelii 98.27 0.00e+00 1069.00
IUUC-Pca-100449 Procavia capensis 90.72 0.00e+00 1209.00
IUUC-Pva-102868 Pteropus vampyrus 91.12 0.00e+00 1179.00
IUUC-Rno-105190 Rattus norvegicus 89.67 0.00e+00 1214.00
IUUC-Sha-107337 Sarcophilus harrisii 83.16 0.00e+00 1090.00
IUUC-Sar-113561 Sorex araneus 95.18 4.00e-94 338.00
IUUC-Ssc-115735 Sus scrofa 90.98 0.00e+00 1163.00
IUUC-Tgu-117025 Taeniopygia guttata 72.13 0.00e+00 877.00
IUUC-Tru-117585 Takifugu rubripes 60.59 0.00e+00 760.00
IUUC-Tsy-118814 Tarsius syrichta 94.18 0.00e+00 1241.00
IUUC-Xtr-132090 Xenopus tropicalis 71.47 0.00e+00 939.00
Created Date 25-Jun-2017

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