iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066796

Ensembl Protein ID

ENSMPUP00000003414.1

UniProt Accession

M3XWG4; M3XWG4_MUSPF

Genbank Protein ID

ENSMPUP00000003414

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01015485

Gene Name

AMFR

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000003445.1	ENSMPUT00000003481.1	ENSMPUP00000003414.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	4.60e-09	36.7	246	284
UBD/Alpha-Helix/CUE	1.90e-11	43.7	361	402

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiC+++++   + lpCgH+fh +Cl  w        +  +CP+Cr
   Q: 246  CAICWDSMQA-ARKLPCGHLFHNSCLRSW------LEQDTSCPTCR 284
           ********99.******************......9*********8 PP

UBD/Alpha-Helix/CUE

   S: 1    dletaleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           +l+ +++q++e+FP+++y ++ ++L ++t s+e +++n+Leg 
   Q: 361  QLNAMAHQIQEMFPQVPYHLVLQDL-QLTRSVEITTDNILEGR 402
           5889*********************.***************95 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MLVAKLIQCI VFGPLRVSER QHLKDKFWNF IFYKFIFIFG VLNVQTVEEV VMWCLWFAGL 60
VFLHLMVQLC KDRFEYLSFS PTTPMSSHGR VLSLLIAMLL SCCGLAVVCC VTGYTHGMHT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTCTAGTAA ATACCGCATG CTGTGTTTTG ATGTTGGTGG CTAAACTAAT CCAGTGTATC 60
GTGTTTGGCC CTCTTCGAGT GAGTGAGAGG CAGGTAAGTC TAACCTTAGG ATGGATTCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR003892--CUE
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51140--CUE
PS50089--ZF_RING_2

Pfam

PF02845--CUE
PF13639--zf-RING_2

SMART

SM00546--CUE
SM00184--RING

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005794--C:Golgi apparatus
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0004872--F:receptor activity
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0032092--P:positive regulation of protein binding
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0051259--P:protein oligomerization
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001300	Ailuropoda melanoleuca	96.34	0.00e+00	1031.00
IUUC-Apl-003404	Anas platyrhynchos	87.96	0.00e+00	918.00
IUUC-Aca-004559	Anolis carolinensis	84.91	0.00e+00	870.00
IUUC-Ame-011640	Astyanax mexicanus	73.62	0.00e+00	751.00
IUUC-Bta-012980	Bos taurus	96.53	0.00e+00	1046.00
IUUC-Cel-018598	Caenorhabditis elegans	24.33	2.00e-28	120.00
IUUC-Cja-019577	Callithrix jacchus	95.26	0.00e+00	1034.00
IUUC-Cfa-020793	Canis familiaris	97.45	0.00e+00	1046.00
IUUC-Cpo-022387	Cavia porcellus	95.99	0.00e+00	1003.00
IUUC-Csa-023168	Chlorocebus sabaeus	95.62	0.00e+00	1039.00
IUUC-Cho-024433	Choloepus hoffmanni	96.69	0.00e+00	859.00
IUUC-Cin-025215	Ciona intestinalis	48.47	1.00e-140	493.00
IUUC-Csv-026133	Ciona savignyi	49.42	5.00e-129	454.00
IUUC-Dre-027594	Danio rerio	72.87	0.00e+00	704.00
IUUC-Dno-029407	Dasypus novemcinctus	96.53	0.00e+00	1011.00
IUUC-Dor-030961	Dipodomys ordii	96.17	0.00e+00	1031.00
IUUC-Ete-032962	Echinops telfairi	87.23	0.00e+00	854.00
IUUC-Eca-033683	Equus caballus	95.26	0.00e+00	1008.00
IUUC-Eeu-034515	Erinaceus europaeus	98.52	3.00e-79	288.00
IUUC-Fca-035398	Felis catus	97.80	0.00e+00	994.00
IUUC-Fal-036758	Ficedula albicollis	81.23	0.00e+00	878.00
IUUC-Gmo-039014	Gadus morhua	73.39	0.00e+00	695.00
IUUC-Gga-040575	Gallus gallus	88.14	0.00e+00	951.00
IUUC-Gac-041414	Gasterosteus aculeatus	73.14	0.00e+00	678.00
IUUC-Hsa-046272	Homo sapiens	95.44	0.00e+00	1036.00
IUUC-Itr-047956	Ictidomys tridecemlineatus	95.99	0.00e+00	1005.00
IUUC-Lch-050491	Latimeria chalumnae	81.05	0.00e+00	802.00
IUUC-Loc-052758	Lepisosteus oculatus	77.20	0.00e+00	759.00
IUUC-Laf-053452	Loxodonta africana	96.72	0.00e+00	1009.00
IUUC-Mcc-055820	Macaca mulatta	95.80	0.00e+00	1041.00
IUUC-Meu-056726	Macropus eugenii	87.90	0.00e+00	751.00
IUUC-Mga-059937	Meleagris gallopavo	88.14	0.00e+00	920.00
IUUC-Mmr-060730	Microcebus murinus	95.62	0.00e+00	999.00
IUUC-Mdo-062771	Monodelphis domestica	92.99	0.00e+00	987.00
IUUC-Mmu-064219	Mus musculus	95.27	0.00e+00	1026.00
IUUC-Mlu-068189	Myotis lucifugus	95.07	0.00e+00	992.00
IUUC-Nle-069239	Nomascus leucogenys	95.62	0.00e+00	1038.00
IUUC-Opr-070702	Ochotona princeps	88.04	2.00e-142	499.00
IUUC-Ont-072033	Oreochromis niloticus	75.10	0.00e+00	739.00
IUUC-Oan-073717	Ornithorhynchus anatinus	85.63	0.00e+00	856.00
IUUC-Ocu-074145	Oryctolagus cuniculus	93.25	0.00e+00	1014.00
IUUC-Ogl-077929	Oryza glaberrima	53.49	6.00e-11	60.10
IUUC-Ola-087152	Oryzias latipes	72.39	0.00e+00	711.00
IUUC-Oga-088486	Otolemur garnettii	96.17	0.00e+00	1006.00
IUUC-Oar-089310	Ovis aries	96.90	0.00e+00	1050.00
IUUC-Ptr-090649	Pan troglodytes	95.44	0.00e+00	1035.00
IUUC-Pan-091692	Papio anubis	91.06	0.00e+00	974.00
IUUC-Psi-093064	Pelodiscus sinensis	94.97	0.00e+00	776.00
IUUC-Pma-094763	Petromyzon marinus	77.78	2.00e-91	328.00
IUUC-Ppa-095969	Physcomitrella patens	29.39	8.00e-36	145.00
IUUC-Pfo-096810	Poecilia formosa	74.56	0.00e+00	717.00
IUUC-Pab-097859	Pongo abelii	95.44	0.00e+00	1039.00
IUUC-Pop-099576	Populus trichocarpa	26.76	3.00e-27	116.00
IUUC-Pca-100344	Procavia capensis	94.55	0.00e+00	966.00
IUUC-Pva-103114	Pteropus vampyrus	68.07	0.00e+00	642.00
IUUC-Rno-105880	Rattus norvegicus	93.36	0.00e+00	999.00
IUUC-Sha-107015	Sarcophilus harrisii	94.00	0.00e+00	960.00
IUUC-Smo-109664	Selaginella moellendorffii	31.61	1.00e-32	134.00
IUUC-Sar-113397	Sorex araneus	98.11	0.00e+00	764.00
IUUC-Ssc-115988	Sus scrofa	93.06	9.00e-149	519.00
IUUC-Tgu-116717	Taeniopygia guttata	89.36	0.00e+00	895.00
IUUC-Tru-117805	Takifugu rubripes	71.82	0.00e+00	739.00
IUUC-Tsy-119442	Tarsius syrichta	90.15	0.00e+00	938.00
IUUC-Tni-119777	Tetraodon nigroviridis	72.77	8.00e-171	593.00
IUUC-Tbe-127322	Tupaia belangeri	67.70	4.00e-109	388.00
IUUC-Ttr-128181	Tursiops truncatus	96.17	0.00e+00	1045.00
IUUC-Vpa-130483	Vicugna pacos	85.61	0.00e+00	645.00
IUUC-Xtr-132614	Xenopus tropicalis	81.21	0.00e+00	756.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence