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Tag Content
UUCD2 ID IUUC-Tgu-117047
UUCD1 version UUC-TaG-00773
Ensembl Protein ID ENSTGUP00000000072.1
UniProt Accession H0YP75; H0YP75_TAEGU
Genbank Protein ID ENSTGUP00000000072
Protein Name Histone-lysine N-methyltransferase
Genbank Nucleotide ID ABQF01045933
Gene Name KMT2A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSTGUG00000000065.1 ENSTGUT00000000072.1 ENSTGUP00000000072.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 5.70e-26 90.3 1338 1391
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCrsk 54
           k+C+vCg++++ +k+l+eC+kCr+ +Hp+Cl+++ ++++p+++k  wiC+kC ++
   Q: 1338 KFCHVCGRQHQATKQLLECNKCRNSYHPECLGPN-YPTKPTKKKkvWICTKCVRC 1391
           58********************************.*****99999*******876 PP
   
Organism Taeniopygia guttata
Protein Sequence
(Fasta)
QDEQFLGFGS DEEVKVRSPT RSPTVKSSPR KPRGRPRSSS DRSSAVLSDS SSVCSPSSKS 60
ETTSMEKVKK KESKSGEKRR GRPPALTSVK FKLSQEKDTS DIQKGSKEEK ESLKKIKRSP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Tgu-117047|E3,PHD|Taeniopygia guttata
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAGGATGAAC AGTTTTTAGG TTTTGGTTCA GATGAAGAAG TCAAAGTACG AAGTCCCACC 60
AGGTCCCCCA CAGGTAAGTT GAAGGTGCAG GATTGGGTGT TGACTTTTGT GATTGCTGTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Tgu-117047|E3,PHD|Taeniopygia guttata
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001487--Bromodomain
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR016569--MeTrfase_trithorax
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50014--BROMODOMAIN_2
PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS50016--ZF_PHD_2
Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC
SMART

SM00297--BROMO
SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET
Gene Ontology

GO:0005829--C:cytosol
GO:0071339--C:MLL1 complex
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0045322--F:unmethylated CpG binding
GO:0008270--F:zinc ion binding
GO:0009952--P:anterior/posterior pattern specification
GO:0032922--P:circadian regulation of gene expression
GO:0060216--P:definitive hemopoiesis
GO:0006306--P:DNA methylation
GO:0035162--P:embryonic hemopoiesis
GO:0035640--P:exploration behavior
GO:0044648--P:histone H3-K4 dimethylation
GO:0080182--P:histone H3-K4 trimethylation
GO:0043984--P:histone H4-K16 acetylation
GO:0048873--P:homeostasis of number of cells within a tissue
GO:0008285--P:negative regulation of cell proliferation
GO:0018026--P:peptidyl-lysine monomethylation
GO:2001040--P:positive regulation of cellular response to drug
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032411--P:positive regulation of transporter activity
GO:0009791--P:post-embryonic development
GO:0006461--P:protein complex assembly
GO:0071440--P:regulation of histone H3-K14 acetylation
GO:1901674--P:regulation of histone H3-K27 acetylation
GO:2000615--P:regulation of histone H3-K9 acetylation
GO:0048172--P:regulation of short-term neuronal synaptic plasticity
GO:0048536--P:spleen development
GO:0008542--P:visual learning
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001054 Aegilops tauschii 34.74 5.00e-13 69.30
IUUC-Aml-002274 Ailuropoda melanoleuca 79.44 0.00e+00 4956.00
IUUC-Atr-002455 Amborella trichopoda 48.10 1.00e-39 158.00
IUUC-Apl-003478 Anas platyrhynchos 92.27 0.00e+00 4745.00
IUUC-Aca-005086 Anolis carolinensis 67.99 0.00e+00 3729.00
IUUC-Aly-006448 Arabidopsis lyrata 48.10 5.00e-40 159.00
IUUC-Ath-006690 Arabidopsis thaliana 47.40 9.00e-38 152.00
IUUC-Ame-011195 Astyanax mexicanus 44.51 0.00e+00 832.00
IUUC-Bta-012974 Bos taurus 79.00 0.00e+00 4984.00
IUUC-Bdi-014882 Brachypodium distachyon 33.17 5.00e-26 112.00
IUUC-Bol-016540 Brassica oleracea 48.05 3.00e-38 153.00
IUUC-Cja-019226 Callithrix jacchus 77.81 0.00e+00 4932.00
IUUC-Cfa-021049 Canis familiaris 79.77 0.00e+00 4978.00
IUUC-Cpo-021459 Cavia porcellus 80.00 0.00e+00 3627.00
IUUC-Cre-022891 Chlamydomonas reinhardtii 50.78 2.00e-39 159.00
IUUC-Csa-023434 Chlorocebus sabaeus 78.81 0.00e+00 3654.00
IUUC-Cho-024652 Choloepus hoffmanni 76.01 0.00e+00 3251.00
IUUC-Cin-025724 Ciona intestinalis 54.43 1.00e-95 344.00
IUUC-Csv-026268 Ciona savignyi 37.20 7.00e-131 461.00
IUUC-Cme-027224 Cyanidioschyzon merolae 34.18 2.00e-12 67.80
IUUC-Dre-028180 Danio rerio 65.31 0.00e+00 1154.00
IUUC-Dno-029068 Dasypus novemcinctus 82.64 0.00e+00 2061.00
IUUC-Dor-030550 Dipodomys ordii 75.32 0.00e+00 4301.00
IUUC-Dme-032023 Drosophila melanogaster 46.55 2.00e-89 325.00
IUUC-Ete-032834 Echinops telfairi 69.66 0.00e+00 2218.00
IUUC-Eca-033615 Equus caballus 79.67 0.00e+00 4858.00
IUUC-Eeu-035136 Erinaceus europaeus 75.12 0.00e+00 1051.00
IUUC-Fca-036453 Felis catus 72.34 0.00e+00 1997.00
IUUC-Fal-037256 Ficedula albicollis 96.39 0.00e+00 6255.00
IUUC-Gmo-038641 Gadus morhua 67.46 0.00e+00 1091.00
IUUC-Gga-040828 Gallus gallus 91.43 0.00e+00 5779.00
IUUC-Gac-041452 Gasterosteus aculeatus 70.34 0.00e+00 1155.00
IUUC-Gma-043554 Glycine max 49.02 5.00e-39 156.00
IUUC-Ggo-045124 Gorilla gorilla 75.35 0.00e+00 3372.00
IUUC-Hsa-046143 Homo sapiens 78.88 0.00e+00 3611.00
IUUC-Hvu-047762 Hordeum vulgare 29.33 5.00e-19 89.00
IUUC-Itr-049024 Ictidomys tridecemlineatus 76.89 0.00e+00 4242.00
IUUC-Lch-049704 Latimeria chalumnae 66.68 0.00e+00 3980.00
IUUC-Lpe-051476 Leersia perrieri 30.09 3.00e-22 100.00
IUUC-Loc-052181 Lepisosteus oculatus 78.63 0.00e+00 1302.00
IUUC-Laf-053946 Loxodonta africana 79.87 0.00e+00 4828.00
IUUC-Mcc-055508 Macaca mulatta 78.76 0.00e+00 3621.00
IUUC-Meu-056485 Macropus eugenii 76.38 0.00e+00 2812.00
IUUC-Mtr-058327 Medicago truncatula 40.44 1.00e-38 154.00
IUUC-Mga-059943 Meleagris gallopavo 88.10 0.00e+00 5339.00
IUUC-Mmr-061178 Microcebus murinus 77.96 0.00e+00 4898.00
IUUC-Mdo-063031 Monodelphis domestica 81.58 0.00e+00 3783.00
IUUC-Mmu-063650 Mus musculus 78.34 0.00e+00 3522.00
IUUC-Mpu-066495 Mustela putorius furo 79.92 0.00e+00 3345.00
IUUC-Mlu-068045 Myotis lucifugus 74.32 0.00e+00 4588.00
IUUC-Nle-069064 Nomascus leucogenys 79.10 0.00e+00 4922.00
IUUC-Opr-071043 Ochotona princeps 74.31 0.00e+00 3625.00
IUUC-Ont-072556 Oreochromis niloticus 65.92 0.00e+00 1120.00
IUUC-Oan-073324 Ornithorhynchus anatinus 75.79 0.00e+00 2097.00
IUUC-Ocu-074190 Oryctolagus cuniculus 77.69 0.00e+00 4837.00
IUUC-Oba-075647 Oryza barthii 49.36 5.00e-39 155.00
IUUC-Obr-076458 Oryza brachyantha 32.66 9.00e-26 111.00
IUUC-Ogl-077851 Oryza glaberrima 32.14 6.00e-25 108.00
IUUC-Ogu-078706 Oryza glumaepatula 31.84 1.00e-25 111.00
IUUC-Oin-079802 Oryza indica 29.13 3.00e-20 92.80
IUUC-Olo-080577 Oryza longistaminata 47.71 2.00e-36 147.00
IUUC-Ome-081214 Oryza meridionalis 49.36 6.00e-39 155.00
IUUC-Oni-083000 Oryza nivara 49.36 6.00e-39 155.00
IUUC-Opu-083842 Oryza punctata 49.36 7.00e-39 155.00
IUUC-Oru-084361 Oryza rufipogon 49.36 7.00e-39 155.00
IUUC-Osa-085421 Oryza sativa 32.14 1.00e-24 107.00
IUUC-Ola-087176 Oryzias latipes 63.13 0.00e+00 1137.00
IUUC-Olu-087718 Ostreococcus lucimarinus 36.76 2.00e-36 148.00
IUUC-Oga-088208 Otolemur garnettii 78.47 0.00e+00 4843.00
IUUC-Oar-090152 Ovis aries 79.39 0.00e+00 5011.00
IUUC-Ptr-091127 Pan troglodytes 78.88 0.00e+00 3591.00
IUUC-Pan-092679 Papio anubis 78.84 0.00e+00 3622.00
IUUC-Psi-094059 Pelodiscus sinensis 86.15 0.00e+00 5553.00
IUUC-Pma-094258 Petromyzon marinus 59.53 0.00e+00 678.00
IUUC-Pfo-096536 Poecilia formosa 67.90 0.00e+00 1122.00
IUUC-Pab-098262 Pongo abelii 79.21 0.00e+00 4913.00
IUUC-Pca-100358 Procavia capensis 75.84 0.00e+00 4605.00
IUUC-Pva-102522 Pteropus vampyrus 74.55 0.00e+00 3898.00
IUUC-Rno-105200 Rattus norvegicus 77.85 0.00e+00 3457.00
IUUC-Sha-107174 Sarcophilus harrisii 81.50 0.00e+00 5033.00
IUUC-Smo-109164 Selaginella moellendorffii 51.30 5.00e-41 162.00
IUUC-Sit-110552 Setaria italica 31.47 2.00e-26 114.00
IUUC-Sly-111176 Solanum lycopersicum 48.37 1.00e-36 148.00
IUUC-Stu-112529 Solanum tuberosum 48.37 7.00e-39 155.00
IUUC-Sar-113503 Sorex araneus 71.64 0.00e+00 2649.00
IUUC-Sbi-114254 Sorghum bicolor 26.92 4.00e-10 59.70
IUUC-Ssc-115509 Sus scrofa 50.98 0.00e+00 754.00
IUUC-Tru-118328 Takifugu rubripes 65.79 0.00e+00 1147.00
IUUC-Tsy-118953 Tarsius syrichta 71.58 0.00e+00 2362.00
IUUC-Tni-120837 Tetraodon nigroviridis 66.34 0.00e+00 1134.00
IUUC-Tae-124647 Triticum aestivum 29.72 7.00e-19 88.20
IUUC-Tbe-127950 Tupaia belangeri 71.95 0.00e+00 2238.00
IUUC-Ttr-128643 Tursiops truncatus 77.57 0.00e+00 4749.00
IUUC-Vpa-130660 Vicugna pacos 79.22 0.00e+00 1769.00
IUUC-Vvi-131476 Vitis vinifera 46.75 4.00e-40 160.00
IUUC-Xtr-132869 Xenopus tropicalis 66.41 0.00e+00 2248.00
IUUC-Xma-133393 Xiphophorus maculatus 64.13 0.00e+00 1073.00
Created Date 25-Jun-2017

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