iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037062

Ensembl Protein ID

ENSFALP00000010438.1

UniProt Accession

U3K5Y4; U3K5Y4_FICAL

Genbank Protein ID

ENSFALP00000010438

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTO01011842

Gene Name

USP28

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000010009.1	ENSFALT00000010480.1	ENSFALP00000010438.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.60e-57	192.5	145	631

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeef 84
           +G+kN+gNtC++ +v+Q+L+++pe+r+l+l      +  e++      +++ +++++lq lf+ ++ + +k v+p++ l+ l+++ ++ 
   Q: 145  VGMKNIGNTCWFSAVIQSLFQLPEFRRLVLGyslpqNVLESCCS-HTGKRNIAFMQELQCLFALMLGTWRKFVDPSAALELLRDVFRS- 231
           6******************************8666533333332.3489999**********************************98. PP
   S: 85   sgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldls 173
            +  qqD++Ef++ lld le++++         +           +  ++  k+++++++lF g++ ++ +    +n+ s+ e+f +++
   Q: 232  AEQPQQDVSEFTHKLLDWLEDAFQ---------L---------TVNATSPGDKSENPMVQLFYGTFLTEGVH--EGNTFSKIETFGQYP 300
           7899*******************2.........2.........234578999***************99887..6788899******** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
           l+v+g +     +l++cLe  + e e++++         ++++  ++ +++klP+vL+++L+Rf+f+++ +++eki++k+efp+ + ++
   Q: 301  LQVNGYR-----NLTECLEGAMVEGEMDEAT------ASQSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHTKLEFPQAMYMD 378
           *******.....9*****9998888888643......344445566779************************************9999 PP
   S: 263  p..fcts.................................................................................. 267
           +  +c++                                                                                  
   Q: 379  RylYCNKdliqmkreemkrlkekmvtlqhklerymeygsgparfplpdmlqyvlefiatkpavssaqssqttllhsqakprvldvlsqp 467
           84466668888888888888888888888888888888888888888888888888777777777777777776666666666666666 PP
   S: 268  ...................peekqke............................................................... 274
                              +     +                                                               
   Q: 468  ngirektdtrtedeaffvaN-----Sspqqnssvelqapvsaaelsecpaphvvseeeltlvqtclqrwrneieqdvqdlkesiarinl 551
           66666665555555555550.....0555555667777777777777777777777788888888888888888888888999999999 PP
   S: 275  ............kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                       ++ Y+L+av+vH+G+++ GHY+a+++++ ++ Wl+++D  Vte+++ee ++e+      ++aY+l+Y 
   Q: 552  sieqmycdpllqQVPYRLHAVLVHEGQANAGHYWAFIYDQPRQrWLKYNDIAVTESSWEELERESFgglrnASAYCLMYI 631
           999999999999***************************87778******************97769************6 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MRFREDCQVL LNQMKEITGI QDSAFLLAAL KAADGDLMEA VTFLTEDPGP EPVQSPAWEG 60
STVSKQLPQD VSAAPTPNNQ DNLCTANTVR PLESPKTPAA ERDAAERAQD AHSAENKNRS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGAAAAACG GGCGGCGCGC GGGGCGCCGG TAGCAGGCGA GGGCTCGGGC GGGCGCTCAG 60
ACACCGCCGC CCCCGCGGGG GCAGCTCCGC GAGTGCTCCC CGCCGCCGAG CAGCGTCGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0016604--C:nuclear body
GO:0043234--C:protein complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008283--P:cell proliferation
GO:0034644--P:cellular response to UV
GO:0000077--P:DNA damage checkpoint
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0016579--P:protein deubiquitination
GO:0007265--P:Ras protein signal transduction
GO:0031647--P:regulation of protein stability
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

fab:101812926

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001836	Ailuropoda melanoleuca	64.46	0.00e+00	902.00
IUUC-Apl-004010	Anas platyrhynchos	79.48	0.00e+00	1186.00
IUUC-Aca-004741	Anolis carolinensis	63.32	0.00e+00	1338.00
IUUC-Acl-008164	Aspergillus clavatus	22.33	4.00e-14	73.90
IUUC-Ame-011910	Astyanax mexicanus	44.26	4.00e-167	582.00
IUUC-Bta-013377	Bos taurus	63.03	0.00e+00	879.00
IUUC-Cfa-020378	Canis familiaris	66.70	0.00e+00	1440.00
IUUC-Cpo-021817	Cavia porcellus	63.24	0.00e+00	877.00
IUUC-Csa-023446	Chlorocebus sabaeus	67.44	0.00e+00	1457.00
IUUC-Cho-024717	Choloepus hoffmanni	54.84	2.00e-125	443.00
IUUC-Cme-027167	Cyanidioschyzon merolae	31.97	4.00e-13	70.50
IUUC-Dor-030955	Dipodomys ordii	60.53	0.00e+00	833.00
IUUC-Ete-032828	Echinops telfairi	63.72	9.00e-166	577.00
IUUC-Eca-034300	Equus caballus	62.68	0.00e+00	868.00
IUUC-Eeu-034458	Erinaceus europaeus	58.68	0.00e+00	1105.00
IUUC-Fca-035753	Felis catus	64.29	0.00e+00	911.00
IUUC-Gmo-039593	Gadus morhua	52.82	0.00e+00	641.00
IUUC-Gga-040878	Gallus gallus	75.36	0.00e+00	1072.00
IUUC-Ggo-045384	Gorilla gorilla	64.20	0.00e+00	885.00
IUUC-Hsa-046277	Homo sapiens	64.29	0.00e+00	889.00
IUUC-Itr-048276	Ictidomys tridecemlineatus	73.83	8.00e-130	457.00
IUUC-Kpa-049349	Komagataella pastoris	32.29	1.00e-09	58.90
IUUC-Loc-052636	Lepisosteus oculatus	60.76	0.00e+00	1267.00
IUUC-Laf-053808	Loxodonta africana	62.59	0.00e+00	832.00
IUUC-Mcc-055473	Macaca mulatta	67.35	0.00e+00	1456.00
IUUC-Meu-056416	Macropus eugenii	52.99	0.00e+00	691.00
IUUC-Mga-060011	Meleagris gallopavo	69.73	0.00e+00	1469.00
IUUC-Mdo-061955	Monodelphis domestica	67.16	0.00e+00	1402.00
IUUC-Mmu-063870	Mus musculus	62.65	0.00e+00	866.00
IUUC-Mpu-066454	Mustela putorius furo	67.32	0.00e+00	1372.00
IUUC-Mlu-067487	Myotis lucifugus	59.74	0.00e+00	807.00
IUUC-Nle-070044	Nomascus leucogenys	63.84	0.00e+00	890.00
IUUC-Opr-070888	Ochotona princeps	74.82	3.00e-122	432.00
IUUC-Oga-088618	Otolemur garnettii	62.95	0.00e+00	880.00
IUUC-Oar-089848	Ovis aries	67.02	0.00e+00	1431.00
IUUC-Ptr-091630	Pan troglodytes	65.38	0.00e+00	634.00
IUUC-Pan-092882	Papio anubis	68.26	0.00e+00	1135.00
IUUC-Psi-093422	Pelodiscus sinensis	74.11	0.00e+00	1625.00
IUUC-Pma-094250	Petromyzon marinus	47.22	2.00e-73	268.00
IUUC-Pab-098337	Pongo abelii	63.75	0.00e+00	889.00
IUUC-Pva-102226	Pteropus vampyrus	58.83	0.00e+00	1143.00
IUUC-Rno-105735	Rattus norvegicus	66.87	0.00e+00	1434.00
IUUC-Sha-107489	Sarcophilus harrisii	62.20	0.00e+00	1339.00
IUUC-Sar-112977	Sorex araneus	51.15	5.00e-148	518.00
IUUC-Sre-115145	Sporisorium reilianum	22.44	6.00e-09	57.00
IUUC-Ssc-115463	Sus scrofa	65.65	0.00e+00	787.00
IUUC-Tgu-116609	Taeniopygia guttata	87.30	0.00e+00	1236.00
IUUC-Tni-119983	Tetraodon nigroviridis	51.16	0.00e+00	659.00
IUUC-Ttr-128887	Tursiops truncatus	58.25	0.00e+00	785.00
IUUC-Uma-129338	Ustilago maydis	22.10	9.00e-12	66.60
IUUC-Vpa-130614	Vicugna pacos	61.38	0.00e+00	1026.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence