iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-092017

Ensembl Protein ID

ENSPANP00000004126.1

UniProt Accession

A0A096MW80; A0A096MW80_PAPAN

Genbank Protein ID

ENSPANP00000004126

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHZZ01014539

Gene Name

FBXW8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000005792.2	ENSPANT00000004317.2	ENSPANP00000004126.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.10e-13	48.8	435	466
UBD/Beta-Prp	1.00e-43	149.7	203	505

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 7    tclaf..sd.tllvsGsdDgtikvWDlrtgvl 35
           tc+++  s  +l+vsG+ Dg +++ Dlr+g+ 
   Q: 435  TCVNLsdSPpNLMVSGNMDGRVRIHDLRSGNI 466
           89999873359*****************9975 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheae.........vtavkfspdgkilvtgseDrtikvwdlst 83
           +l++ +++v+++v+   ++ ++++g+++g ++vwd++t+++++ + + e+e         v+ v+++++  + v + eD+++++wdl+t
   Q: 203  ELEHIPDAVLCDVHS--HDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEedepgmqpnVSFVRINSS--LAVAAYEDGFLNIWDLRT 287
           567778999998888..9***********************9999777777789999999*********..9***************** PP
   S: 84   gkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkl 171
           gk+ ++  +h++++ +l++s+++ +++++s+ +++++   e+g++  + + +  ++v+++++ p++ ++ v+ ++ + ++ + lk ++ 
   Q: 288  GKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLSPSEEGYWQIAAEFEVPKLVQYLEIVPETgRCPVAVAAAGDLM-YLLKAEDS 375
           ***999999********************************************************99************8.******** PP
   S: 172  lrtltgghtdsvyslsfdsng.....kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs.pnderlvsgssDgsiriWdlrsg 254
            rtl  +h ++v++l+++ n+     + l ++ + +++ +++l++g+ + +l +  + +++v++s +  +++vsg++Dg +ri+dlrsg
   Q: 376  ARTLLYAHGPPVTCLDVSANQvafgvQGLGWVYEGSKILVYSLEAGRRLLKLGNVLRDFTCVNLSdSPPNLMVSGNMDGRVRIHDLRSG 464
           *****************************************************************78899******************* PP
   S: 255  dllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkkne 298
           ++  +l+ h+  v++v+v   +d+++v+g+e++ v +w++++n+
   Q: 465  NIALSLSAHQLGVSAVQV---DDWKIVSGGEEGLVSVWDYRTNQ 505
           **********99999999...*******************9987 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MDDCSLDEFR RRWQEELAQA QAPRKRRRPE AAERWARRPE VVPERGEQAS GDPALAQCLL 60
EGGRPPAARA TRTEGQDVAS RSRSPLAREG AGGGEQLVDQ LFRDLNEMND VPFFGIQLPY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTAGGGCTG CGGCAACAGC GGCTTCCGGC CGCGGCGGAC ACTTCCCTGG AAGGGACTGT 60
CCCGTGGCAC CCGGTGGAAC CGAGGAGAAC GTGGAGCGCC GGGAGCAGTG AATATGGACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:1990393--C:3M complex
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008283--P:cell proliferation
GO:0007030--P:Golgi organization
GO:0060716--P:labyrinthine layer blood vessel development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0060712--P:spongiotrophoblast layer development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001274	Ailuropoda melanoleuca	87.64	0.00e+00	936.00
IUUC-Apl-003239	Anas platyrhynchos	60.73	0.00e+00	662.00
IUUC-Aca-004756	Anolis carolinensis	57.14	2.00e-126	445.00
IUUC-Ame-011198	Astyanax mexicanus	53.23	4.00e-56	211.00
IUUC-Bta-012430	Bos taurus	55.99	3.00e-154	538.00
IUUC-Cja-019131	Callithrix jacchus	87.12	0.00e+00	1011.00
IUUC-Cfa-021022	Canis familiaris	78.54	0.00e+00	907.00
IUUC-Cpo-021898	Cavia porcellus	76.90	0.00e+00	889.00
IUUC-Csa-023452	Chlorocebus sabaeus	97.66	0.00e+00	1132.00
IUUC-Cho-024759	Choloepus hoffmanni	73.24	0.00e+00	819.00
IUUC-Dre-028123	Danio rerio	42.03	2.00e-140	493.00
IUUC-Dno-029045	Dasypus novemcinctus	87.09	0.00e+00	825.00
IUUC-Dor-030433	Dipodomys ordii	76.73	0.00e+00	759.00
IUUC-Ete-032465	Echinops telfairi	76.86	0.00e+00	737.00
IUUC-Eca-034134	Equus caballus	86.79	0.00e+00	890.00
IUUC-Eeu-035047	Erinaceus europaeus	76.53	0.00e+00	761.00
IUUC-Fca-036574	Felis catus	86.89	0.00e+00	875.00
IUUC-Fal-037665	Ficedula albicollis	58.68	2.00e-167	582.00
IUUC-Gmo-039137	Gadus morhua	39.53	6.00e-67	247.00
IUUC-Gga-040711	Gallus gallus	58.45	0.00e+00	650.00
IUUC-Gac-041675	Gasterosteus aculeatus	49.47	2.00e-49	188.00
IUUC-Ggo-045331	Gorilla gorilla	97.56	0.00e+00	998.00
IUUC-Hsa-046240	Homo sapiens	94.82	0.00e+00	1107.00
IUUC-Itr-048412	Ictidomys tridecemlineatus	88.01	0.00e+00	874.00
IUUC-Loc-052631	Lepisosteus oculatus	48.19	2.00e-162	565.00
IUUC-Laf-054127	Loxodonta africana	72.03	8.00e-55	205.00
IUUC-Mcc-055083	Macaca mulatta	96.82	0.00e+00	1120.00
IUUC-Mga-060113	Meleagris gallopavo	61.62	0.00e+00	637.00
IUUC-Mmr-061780	Microcebus murinus	83.81	0.00e+00	906.00
IUUC-Mdo-063066	Monodelphis domestica	60.18	0.00e+00	697.00
IUUC-Mmu-063524	Mus musculus	75.75	0.00e+00	823.00
IUUC-Mpu-066913	Mustela putorius furo	87.64	0.00e+00	910.00
IUUC-Mlu-067924	Myotis lucifugus	82.58	0.00e+00	914.00
IUUC-Nle-069558	Nomascus leucogenys	93.19	0.00e+00	1018.00
IUUC-Opr-070506	Ochotona princeps	81.11	0.00e+00	889.00
IUUC-Ont-071514	Oreochromis niloticus	47.35	2.00e-141	496.00
IUUC-Ocu-074477	Oryctolagus cuniculus	84.95	0.00e+00	856.00
IUUC-Ola-087416	Oryzias latipes	43.60	6.00e-144	504.00
IUUC-Oga-088643	Otolemur garnettii	82.94	0.00e+00	926.00
IUUC-Oar-090172	Ovis aries	85.19	0.00e+00	873.00
IUUC-Ptr-090870	Pan troglodytes	94.82	0.00e+00	1101.00
IUUC-Psi-093794	Pelodiscus sinensis	62.53	0.00e+00	645.00
IUUC-Pfo-096192	Poecilia formosa	49.31	1.00e-143	503.00
IUUC-Pab-097882	Pongo abelii	93.63	0.00e+00	1087.00
IUUC-Pca-100902	Procavia capensis	84.23	3.00e-153	535.00
IUUC-Pva-103139	Pteropus vampyrus	82.97	0.00e+00	943.00
IUUC-Rno-105798	Rattus norvegicus	79.29	0.00e+00	838.00
IUUC-Sha-106576	Sarcophilus harrisii	64.34	0.00e+00	657.00
IUUC-Ssc-115923	Sus scrofa	75.88	0.00e+00	895.00
IUUC-Tgu-116667	Taeniopygia guttata	52.80	1.00e-106	379.00
IUUC-Tru-118323	Takifugu rubripes	42.83	3.00e-133	468.00
IUUC-Tsy-118818	Tarsius syrichta	69.69	6.00e-96	343.00
IUUC-Tni-120438	Tetraodon nigroviridis	41.68	6.00e-131	461.00
IUUC-Tbe-127784	Tupaia belangeri	83.01	1.00e-96	346.00
IUUC-Ttr-128288	Tursiops truncatus	72.94	0.00e+00	798.00
IUUC-Vpa-130307	Vicugna pacos	78.22	0.00e+00	787.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence