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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105798
UUCD1 version UUC-RaN-00278
Ensembl Protein ID ENSRNOP00000069282.1
UniProt Accession P0DL28; FBXW8_RAT
Genbank Protein ID ENSRNOP00000069282
Protein Name F-box/WD repeat-containing protein 8; F-box and WD-40 domain-containing protein 8
Genbank Nucleotide ID AABR06072298
Gene Name Fbxw8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000001126.7 ENSRNOT00000080853.1 ENSRNOP00000069117.1
ENSRNOG00000001126.7 ENSRNOT00000079510.1 ENSRNOP00000069282.1
ENSRNOG00000001126.7 ENSRNOT00000064756.3 ENSRNOP00000059618.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.90e-14 53.6 472 502
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrt 32
           H+ +v++++ +d+ +vsG+  g + vWD+r 
   Q: 472  HQLGVSAVQMDDWKIVSGGEEGLVSVWDYRM 502
           7778999999669***************875 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation. Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (By similarity). The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain.
 Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation. Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (By similarity). The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain.
Protein Sequence
(Fasta)
MEDHNLEEFR QRWQEELAHS QVLRRRRRLE AGERRPRRPE AGARGEPASG YLGLAQGLLE 60
GAGRPPAPRP GRTDRKDVSS RSRSPPDRDA AEPEPLVDQL IRDLNEMDDV PFFDVHLPYE 120
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Protein Fasta Sequence


>IUUC-Rno-105798|E3,WD_repeat|Rattus norvegicus
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Nucleotide Sequence
(Fasta)
CGTAGGCCTG GGAGCGGCAA GCATGGAGGA CCATAACCTG GAGGAGTTCC GCCAGCGCTG 60
GCAGGAGGAA TTGGCGCACT CGCAGGTGCT GAGGCGACGG CGGCGGCTCG AGGCTGGGGA 120
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Nucleotide Fasta Sequence


>IUUC-Rno-105798|E3,WD_repeat|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0333--Golgi apparatus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR001810--F-box_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12937--F-box-like
SMART

SM00256--FBOX
SM00320--WD40
Gene Ontology

GO:1990393--C:3M complex
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008283--P:cell proliferation
GO:0007030--P:Golgi organization
GO:0060716--P:labyrinthine layer blood vessel development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0016567--P:protein ubiquitination
GO:0060712--P:spongiotrophoblast layer development
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001274 Ailuropoda melanoleuca 85.91 0.00e+00 936.00
IUUC-Apl-003239 Anas platyrhynchos 60.62 0.00e+00 684.00
IUUC-Aca-004756 Anolis carolinensis 60.00 3.00e-135 474.00
IUUC-Ame-011198 Astyanax mexicanus 40.55 4.00e-57 214.00
IUUC-Bta-012430 Bos taurus 52.61 3.00e-138 485.00
IUUC-Cja-019131 Callithrix jacchus 73.87 0.00e+00 840.00
IUUC-Cfa-021022 Canis familiaris 76.21 0.00e+00 909.00
IUUC-Cpo-021898 Cavia porcellus 77.74 0.00e+00 913.00
IUUC-Csa-023452 Chlorocebus sabaeus 77.05 0.00e+00 904.00
IUUC-Cho-024759 Choloepus hoffmanni 71.91 0.00e+00 793.00
IUUC-Dre-028123 Danio rerio 43.65 2.00e-147 515.00
IUUC-Dno-029045 Dasypus novemcinctus 87.31 0.00e+00 847.00
IUUC-Dor-030433 Dipodomys ordii 77.51 0.00e+00 766.00
IUUC-Ete-032465 Echinops telfairi 80.39 0.00e+00 765.00
IUUC-Eca-034134 Equus caballus 86.59 0.00e+00 904.00
IUUC-Eeu-035047 Erinaceus europaeus 75.97 0.00e+00 774.00
IUUC-Fca-036574 Felis catus 85.92 0.00e+00 886.00
IUUC-Fal-037665 Ficedula albicollis 59.88 3.00e-174 604.00
IUUC-Gmo-039137 Gadus morhua 39.53 2.00e-66 246.00
IUUC-Gga-040711 Gallus gallus 59.46 0.00e+00 664.00
IUUC-Gac-041675 Gasterosteus aculeatus 53.16 2.00e-56 211.00
IUUC-Ggo-045331 Gorilla gorilla 79.88 0.00e+00 822.00
IUUC-Hsa-046240 Homo sapiens 77.42 0.00e+00 892.00
IUUC-Itr-048412 Ictidomys tridecemlineatus 87.40 0.00e+00 885.00
IUUC-Loc-052631 Lepisosteus oculatus 49.15 1.00e-165 577.00
IUUC-Laf-054127 Loxodonta africana 80.42 3.00e-64 236.00
IUUC-Mcc-055083 Macaca mulatta 77.59 0.00e+00 885.00
IUUC-Mga-060113 Meleagris gallopavo 61.61 0.00e+00 652.00
IUUC-Mmr-061780 Microcebus murinus 82.80 0.00e+00 927.00
IUUC-Mdo-063066 Monodelphis domestica 59.72 0.00e+00 705.00
IUUC-Mmu-063524 Mus musculus 92.14 0.00e+00 1001.00
IUUC-Mpu-066913 Mustela putorius furo 85.88 0.00e+00 908.00
IUUC-Mlu-067924 Myotis lucifugus 82.08 0.00e+00 931.00
IUUC-Nle-069558 Nomascus leucogenys 77.49 0.00e+00 845.00
IUUC-Opr-070506 Ochotona princeps 82.89 0.00e+00 905.00
IUUC-Ont-071514 Oreochromis niloticus 42.86 3.00e-147 515.00
IUUC-Ocu-074477 Oryctolagus cuniculus 85.57 0.00e+00 871.00
IUUC-Ola-087416 Oryzias latipes 45.38 2.00e-148 519.00
IUUC-Oga-088643 Otolemur garnettii 86.88 0.00e+00 925.00
IUUC-Oar-090172 Ovis aries 85.16 0.00e+00 886.00
IUUC-Ptr-090870 Pan troglodytes 77.55 0.00e+00 895.00
IUUC-Pan-092017 Papio anubis 76.21 0.00e+00 894.00
IUUC-Psi-093794 Pelodiscus sinensis 62.63 0.00e+00 646.00
IUUC-Pfo-096192 Poecilia formosa 50.29 1.00e-147 516.00
IUUC-Pab-097882 Pongo abelii 76.72 0.00e+00 879.00
IUUC-Pca-100902 Procavia capensis 72.59 2.00e-139 489.00
IUUC-Pva-103139 Pteropus vampyrus 81.30 0.00e+00 940.00
IUUC-Sha-106576 Sarcophilus harrisii 61.82 0.00e+00 667.00
IUUC-Ssc-115923 Sus scrofa 73.66 0.00e+00 875.00
IUUC-Tgu-116667 Taeniopygia guttata 57.33 1.00e-119 422.00
IUUC-Tru-118323 Takifugu rubripes 44.60 6.00e-143 501.00
IUUC-Tsy-118818 Tarsius syrichta 76.77 5.00e-110 390.00
IUUC-Tni-120438 Tetraodon nigroviridis 43.78 9.00e-141 493.00
IUUC-Tbe-127784 Tupaia belangeri 91.26 3.00e-111 395.00
IUUC-Ttr-128288 Tursiops truncatus 76.29 0.00e+00 791.00
IUUC-Vpa-130307 Vicugna pacos 80.88 0.00e+00 767.00
Created Date 25-Jun-2017

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