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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064292
UUCD1 version UUC-MuM-00868
Ensembl Protein ID ENSMUSP00000112076.1
UniProt Accession Q99LC2; Q3UMB8; Q8BJW1; Q9CSU8; CSTF1_MOUSE
Genbank Protein ID BAB27929.1; BAC34379.1; BAC37353.1; BAE26180.1; AAH03440.1
Protein Name Cleavage stimulation factor subunit 1; CF-1 50 kDa subunit; Cleavage stimulation factor 50 kDa subunit
Genbank Nucleotide ID AK011943; AK050686; AK078667; AK145001; BC003440
Gene Name Cstf1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000027498.14 ENSMUST00000116375.1 ENSMUSP00000112076.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 6.30e-28 96.8 172 202
UBD/Beta-Prp 1.20e-73 249.1 102 429
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           H d+vtclaf ++  +l+sGs+D t+k++D+
   Q: 172  HVDEVTCLAFhPTeQILASGSRDYTLKLFDY 202
           9**********77799**************7 PP
   

   UBD/Beta-Prp
   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkl.......................lrslsgheaevtavkfspdgkilvt 69
           ++ ++hk+++++ ++s+d++l+atgs+d++ik+ d++++ +                       +r+l++h +evt++ f+p+++il++
   Q: 102  CYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAksampievmmnetaqqnmenhpvIRTLYDHVDEVTCLAFHPTEQILAS 190
           67889*********************************988************************************************ PP
   S: 70   gseDrtikvwdlstgkcvhtlk..ghedsvlslsfspsgdklvsGshdrtirvwdletgqclee..tlsghdgvvncvvvhpdgnllvs 154
           gs+D+t+k++d+s+++  +++k  ++ ++++s+sf+psgd++++G+++ t+r++d++t qc+ +  ++++h++++++v+++p++n++v+
   Q: 191  GSRDYTLKLFDYSKPSAKRAFKyiQEAEMLRSISFHPSGDFILVGTQHPTLRLYDINTFQCFVScnPQDQHTDAICSVNYNPSANMYVT 279
           *****************99999999***************************************99*********************** PP
   S: 155  GslDrtvrlWdlktgkllrtltgghtdsvysls.fdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs....pnderlv 238
           Gs+D++++lWd  ++++++t++++h+++  + + f++n+k+++s ++d+  klw+++tg+++++++g     ++v+ +    +++e ++
   Q: 280  GSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAiFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTqavfNHTEDYI 368
           *********************9999998777666***********************************99999888877789****** PP
   S: 239  sgssDgsiri..Wdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkkn 297
              ++++i++  Wd+r+ +  + l+l +++++ + v+s++++ ++++s+d ++++w  +++
   Q: 369  LLPDERTISLccWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRST 429
           ********9888********************************************98765 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA (By similarity).
 One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA (By similarity).
Protein Sequence
(Fasta)
MYRTKVGLKD RQQLYKLIIS QLLYDGYISI ANGLINEIKP QSVCAPSEQL LHLIKLGMEN 60
DDTAVQYAIG RSDTVAPGTG IDLEFDADVQ TMSPEASEYE TCYVTSHKGP CRVATYSRDG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064292|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGAGCTGTCG GAGCCCGGAA GTGGTGCACC AACGGCCCGT CCGATCTGCG GCCGTTCTAT 60
CGCCCGCCGT GCTCCCCAGG ATCAGGCGTT CGCCAGTCAC ACACAGCCCT TTGGATTCAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064292|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0507--mRNA processing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR032028--CSTF1_dimer
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF16699--CSTF1_dimer
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0003723--F:RNA binding
GO:0006397--P:mRNA processing
KEGG mmu:67337
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002163 Ailuropoda melanoleuca 99.77 0.00e+00 907.00
IUUC-Atr-002687 Amborella trichopoda 38.16 2.00e-67 249.00
IUUC-Apl-003438 Anas platyrhynchos 98.14 0.00e+00 894.00
IUUC-Aca-005178 Anolis carolinensis 97.22 0.00e+00 889.00
IUUC-Aly-005791 Arabidopsis lyrata 37.03 2.00e-79 289.00
IUUC-Ath-006689 Arabidopsis thaliana 38.21 4.00e-80 291.00
IUUC-Ame-011217 Astyanax mexicanus 92.25 3.00e-163 566.00
IUUC-Bta-012619 Bos taurus 99.54 0.00e+00 906.00
IUUC-Bdi-014515 Brachypodium distachyon 43.12 6.00e-79 287.00
IUUC-Bra-017450 Brassica rapa 36.49 2.00e-74 273.00
IUUC-Cel-018151 Caenorhabditis elegans 51.97 2.00e-133 468.00
IUUC-Cja-019304 Callithrix jacchus 99.54 0.00e+00 905.00
IUUC-Cfa-020208 Canis familiaris 99.77 0.00e+00 907.00
IUUC-Cpo-022245 Cavia porcellus 99.77 0.00e+00 907.00
IUUC-Csa-023066 Chlorocebus sabaeus 99.54 0.00e+00 905.00
IUUC-Cho-024770 Choloepus hoffmanni 99.73 0.00e+00 789.00
IUUC-Cin-025621 Ciona intestinalis 57.14 8.00e-152 530.00
IUUC-Csv-026071 Ciona savignyi 60.14 5.00e-163 567.00
IUUC-Dre-028254 Danio rerio 90.02 0.00e+00 832.00
IUUC-Dno-029903 Dasypus novemcinctus 99.77 0.00e+00 907.00
IUUC-Dor-030423 Dipodomys ordii 99.54 0.00e+00 907.00
IUUC-Dme-031993 Drosophila melanogaster 55.11 4.00e-133 468.00
IUUC-Ete-032689 Echinops telfairi 98.66 2.00e-82 299.00
IUUC-Eca-033316 Equus caballus 99.54 0.00e+00 906.00
IUUC-Eeu-035001 Erinaceus europaeus 94.66 0.00e+00 863.00
IUUC-Fca-036447 Felis catus 99.77 0.00e+00 907.00
IUUC-Fal-037601 Ficedula albicollis 98.14 0.00e+00 894.00
IUUC-Gmo-038531 Gadus morhua 88.22 0.00e+00 801.00
IUUC-Gga-040869 Gallus gallus 97.91 0.00e+00 893.00
IUUC-Gac-042380 Gasterosteus aculeatus 89.40 0.00e+00 822.00
IUUC-Gma-043478 Glycine max 38.81 2.00e-83 303.00
IUUC-Ggo-045302 Gorilla gorilla 99.54 0.00e+00 905.00
IUUC-Hsa-045678 Homo sapiens 99.54 0.00e+00 905.00
IUUC-Hvu-047301 Hordeum vulgare 43.62 6.00e-81 294.00
IUUC-Itr-048259 Ictidomys tridecemlineatus 99.77 0.00e+00 907.00
IUUC-Lch-050319 Latimeria chalumnae 94.43 0.00e+00 867.00
IUUC-Lpe-051440 Leersia perrieri 40.45 2.00e-66 246.00
IUUC-Loc-052035 Lepisosteus oculatus 91.65 0.00e+00 842.00
IUUC-Laf-054275 Loxodonta africana 99.77 0.00e+00 907.00
IUUC-Mcc-055857 Macaca mulatta 86.31 0.00e+00 751.00
IUUC-Meu-056194 Macropus eugenii 99.37 5.00e-92 330.00
IUUC-Mtr-058667 Medicago truncatula 38.32 7.00e-76 277.00
IUUC-Mga-059710 Meleagris gallopavo 97.91 0.00e+00 893.00
IUUC-Mmr-060604 Microcebus murinus 99.77 0.00e+00 907.00
IUUC-Mdo-062953 Monodelphis domestica 99.07 0.00e+00 903.00
IUUC-Mac-064568 Musa acuminata 44.14 4.00e-78 284.00
IUUC-Mpu-066294 Mustela putorius furo 67.79 8.00e-164 570.00
IUUC-Mlu-067995 Myotis lucifugus 98.84 0.00e+00 897.00
IUUC-Nle-069322 Nomascus leucogenys 99.54 0.00e+00 905.00
IUUC-Opr-070580 Ochotona princeps 99.30 0.00e+00 904.00
IUUC-Ont-072554 Oreochromis niloticus 91.88 0.00e+00 845.00
IUUC-Oan-072856 Ornithorhynchus anatinus 98.61 0.00e+00 899.00
IUUC-Ocu-074150 Oryctolagus cuniculus 87.96 0.00e+00 766.00
IUUC-Oba-075585 Oryza barthii 36.60 3.00e-69 255.00
IUUC-Obr-076069 Oryza brachyantha 38.46 1.00e-74 273.00
IUUC-Ogl-077045 Oryza glaberrima 39.74 2.00e-79 289.00
IUUC-Ogu-078697 Oryza glumaepatula 39.74 4.00e-75 276.00
IUUC-Oin-080119 Oryza indica 39.74 2.00e-79 289.00
IUUC-Olo-081093 Oryza longistaminata 31.56 7.00e-44 173.00
IUUC-Ome-081718 Oryza meridionalis 32.82 5.00e-56 212.00
IUUC-Oni-082072 Oryza nivara 36.60 3.00e-69 255.00
IUUC-Opu-084080 Oryza punctata 34.71 2.00e-56 213.00
IUUC-Oru-085070 Oryza rufipogon 36.88 1.00e-68 255.00
IUUC-Osa-086149 Oryza sativa 39.74 2.00e-79 289.00
IUUC-Ola-086697 Oryzias latipes 91.42 0.00e+00 844.00
IUUC-Oga-088697 Otolemur garnettii 99.77 0.00e+00 907.00
IUUC-Oar-089774 Ovis aries 99.77 0.00e+00 907.00
IUUC-Ptr-090924 Pan troglodytes 99.54 0.00e+00 905.00
IUUC-Pan-092373 Papio anubis 99.54 0.00e+00 904.00
IUUC-Psi-094001 Pelodiscus sinensis 97.91 0.00e+00 892.00
IUUC-Pma-094274 Petromyzon marinus 73.89 0.00e+00 695.00
IUUC-Ppa-095562 Physcomitrella patens 36.18 2.00e-80 293.00
IUUC-Pfo-097235 Poecilia formosa 91.42 0.00e+00 841.00
IUUC-Pab-098608 Pongo abelii 99.54 0.00e+00 905.00
IUUC-Pca-100268 Procavia capensis 99.54 0.00e+00 906.00
IUUC-Ppe-101425 Prunus persica 41.56 1.00e-82 300.00
IUUC-Pva-103183 Pteropus vampyrus 99.77 0.00e+00 907.00
IUUC-Rno-105097 Rattus norvegicus 100.00 0.00e+00 907.00
IUUC-Sha-107642 Sarcophilus harrisii 99.07 0.00e+00 903.00
IUUC-Smo-108680 Selaginella moellendorffii 35.83 2.00e-77 283.00
IUUC-Sit-110471 Setaria italica 40.89 5.00e-82 298.00
IUUC-Sly-111143 Solanum lycopersicum 33.89 2.00e-33 135.00
IUUC-Stu-111926 Solanum tuberosum 44.10 5.00e-33 133.00
IUUC-Sar-112947 Sorex araneus 100.00 7.00e-175 605.00
IUUC-Sbi-113769 Sorghum bicolor 42.73 3.00e-79 288.00
IUUC-Ssc-115736 Sus scrofa 99.77 0.00e+00 907.00
IUUC-Tgu-117457 Taeniopygia guttata 98.14 0.00e+00 894.00
IUUC-Tru-117760 Takifugu rubripes 91.18 0.00e+00 842.00
IUUC-Tsy-118943 Tarsius syrichta 98.84 0.00e+00 893.00
IUUC-Tni-120081 Tetraodon nigroviridis 91.88 0.00e+00 846.00
IUUC-Tca-121190 Theobroma cacao 40.19 5.00e-86 311.00
IUUC-Tae-125535 Triticum aestivum 44.51 8.00e-84 304.00
IUUC-Tur-126329 Triticum urartu 44.51 2.00e-83 303.00
IUUC-Tbe-127878 Tupaia belangeri 98.35 0.00e+00 880.00
IUUC-Ttr-128985 Tursiops truncatus 99.77 0.00e+00 907.00
IUUC-Vpa-130147 Vicugna pacos 99.54 0.00e+00 905.00
IUUC-Vvi-130935 Vitis vinifera 39.07 5.00e-85 308.00
IUUC-Xtr-132482 Xenopus tropicalis 95.13 0.00e+00 870.00
IUUC-Xma-133929 Xiphophorus maculatus 91.42 0.00e+00 841.00
Created Date 25-Jun-2017

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