iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-132171

Ensembl Protein ID

ENSXETP00000027035.3

UniProt Accession

Q25C14; Q25C14_XENTR

Genbank Protein ID

BAE81788.1

Protein Name

Estrogen receptor; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1

Genbank Nucleotide ID

AAMC01057144

Gene Name

esr1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000012364.3	ENSXETT00000027035.3	ENSXETP00000027035.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	69.41	0.00e+00	736.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Xenopus tropicalis

Functional Description
(View)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Protein Sequence
(Fasta)

MTMPLHNKTT GVTLLHQIQS SELETLSRPP LKIPLERPLS EMYVENNRTG IFNYPEGTTY 60
DFAAAAAPVY SSASLSYAAS SETFGSSSLT GLHTLNNVPP SPVVFLQTPQ LSPFIHHHGQ 120

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Nucleotide Sequence
(Fasta)

GTTTTCTGCT TTAGCTCACA TCAGGTTGTG CTCTGTTTTC AGGTGGTTCT ACAAGTGCTG 60
ACACCACAGT TTAGCAGCTG GAACAGTGGA CAGCCATGTC ACATTTTCTT TGCCAGTAGC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR024736--Oestrogen-typ_rcpt_final_C_dom
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF12743--ESR1_C
PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00543--OESTROGENR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005634--C:nucleus
GO:0030284--F:estrogen receptor activity
GO:0043565--F:sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	75.72	0.00e+00	641.00
IUUC-Apl-003688	Anas platyrhynchos	80.49	0.00e+00	795.00
IUUC-Aca-005222	Anolis carolinensis	74.32	0.00e+00	813.00
IUUC-Ame-010731	Astyanax mexicanus	55.72	4.00e-136	478.00
IUUC-Bta-013112	Bos taurus	67.45	0.00e+00	740.00
IUUC-Cja-019408	Callithrix jacchus	69.92	0.00e+00	760.00
IUUC-Cfa-020694	Canis familiaris	66.23	0.00e+00	745.00
IUUC-Cpo-021426	Cavia porcellus	68.29	0.00e+00	731.00
IUUC-Csa-023736	Chlorocebus sabaeus	75.05	0.00e+00	695.00
IUUC-Cho-024593	Choloepus hoffmanni	29.86	2.00e-22	100.00
IUUC-Dre-027698	Danio rerio	51.36	2.00e-137	482.00
IUUC-Dno-029477	Dasypus novemcinctus	76.77	0.00e+00	645.00
IUUC-Dor-030572	Dipodomys ordii	75.40	1.00e-179	622.00
IUUC-Dme-031794	Drosophila melanogaster	32.48	2.00e-22	101.00
IUUC-Ete-032849	Echinops telfairi	65.14	1.00e-145	509.00
IUUC-Eca-033605	Equus caballus	67.39	0.00e+00	720.00
IUUC-Eeu-034683	Erinaceus europaeus	77.46	6.00e-88	317.00
IUUC-Fca-035928	Felis catus	75.62	0.00e+00	638.00
IUUC-Fal-036754	Ficedula albicollis	78.34	0.00e+00	871.00
IUUC-Gmo-038872	Gadus morhua	57.70	3.00e-113	401.00
IUUC-Gga-040988	Gallus gallus	78.17	0.00e+00	854.00
IUUC-Gac-042015	Gasterosteus aculeatus	61.93	2.00e-129	455.00
IUUC-Ggo-044749	Gorilla gorilla	69.08	0.00e+00	751.00
IUUC-Hsa-046944	Homo sapiens	68.74	0.00e+00	749.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	69.92	0.00e+00	759.00
IUUC-Lch-049855	Latimeria chalumnae	30.15	8.00e-28	117.00
IUUC-Loc-052414	Lepisosteus oculatus	61.95	0.00e+00	674.00
IUUC-Laf-054483	Loxodonta africana	32.44	2.00e-22	100.00
IUUC-Mcc-054781	Macaca mulatta	69.08	0.00e+00	751.00
IUUC-Meu-056232	Macropus eugenii	72.50	0.00e+00	780.00
IUUC-Mga-059319	Meleagris gallopavo	77.63	0.00e+00	852.00
IUUC-Mmr-061636	Microcebus murinus	68.21	1.00e-122	432.00
IUUC-Mdo-062661	Monodelphis domestica	73.73	0.00e+00	809.00
IUUC-Mmu-063330	Mus musculus	69.43	0.00e+00	727.00
IUUC-Mpu-065757	Mustela putorius furo	68.84	0.00e+00	761.00
IUUC-Mlu-067712	Myotis lucifugus	74.79	0.00e+00	680.00
IUUC-Nle-069283	Nomascus leucogenys	75.00	0.00e+00	689.00
IUUC-Opr-070391	Ochotona princeps	66.50	0.00e+00	743.00
IUUC-Ont-071369	Oreochromis niloticus	52.68	6.00e-122	431.00
IUUC-Oan-073734	Ornithorhynchus anatinus	59.36	6.00e-101	360.00
IUUC-Ocu-074292	Oryctolagus cuniculus	69.73	0.00e+00	751.00
IUUC-Oba-075103	Oryza barthii	24.10	3.00e-03	36.60
IUUC-Ogu-079042	Oryza glumaepatula	21.67	2.00e-04	40.80
IUUC-Olo-080944	Oryza longistaminata	24.10	1.00e-03	36.20
IUUC-Oni-082560	Oryza nivara	21.67	1.00e-03	37.70
IUUC-Ola-087052	Oryzias latipes	54.41	1.00e-129	456.00
IUUC-Oga-088586	Otolemur garnettii	70.23	0.00e+00	747.00
IUUC-Oar-090156	Ovis aries	75.39	0.00e+00	643.00
IUUC-Ptr-091321	Pan troglodytes	69.24	0.00e+00	752.00
IUUC-Pan-092851	Papio anubis	68.91	0.00e+00	749.00
IUUC-Psi-093434	Pelodiscus sinensis	76.57	0.00e+00	841.00
IUUC-Pfo-097379	Poecilia formosa	57.61	2.00e-135	476.00
IUUC-Pab-097735	Pongo abelii	69.08	0.00e+00	750.00
IUUC-Pca-100861	Procavia capensis	32.44	1.00e-22	100.00
IUUC-Ppe-101359	Prunus persica	38.46	2.30e-01	29.60
IUUC-Pva-102125	Pteropus vampyrus	69.19	0.00e+00	744.00
IUUC-Rno-106121	Rattus norvegicus	70.37	0.00e+00	726.00
IUUC-Sha-107547	Sarcophilus harrisii	74.07	0.00e+00	805.00
IUUC-Sar-113650	Sorex araneus	64.16	2.00e-144	505.00
IUUC-Ssc-115945	Sus scrofa	32.44	1.00e-22	101.00
IUUC-Tgu-117175	Taeniopygia guttata	77.66	0.00e+00	865.00
IUUC-Tru-117545	Takifugu rubripes	52.10	3.00e-141	496.00
IUUC-Tsy-119586	Tarsius syrichta	64.71	4.00e-172	597.00
IUUC-Tni-120121	Tetraodon nigroviridis	51.62	5.00e-143	501.00
IUUC-Tbe-127548	Tupaia belangeri	69.51	1.00e-146	513.00
IUUC-Ttr-128374	Tursiops truncatus	70.59	0.00e+00	626.00
IUUC-Vpa-130464	Vicugna pacos	66.37	2.00e-123	435.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence