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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046225
Ensembl Protein ID ENSP00000378752.1
UniProt Accession Q9BTC0; A8MY65; B9EH82; E1P5I1; O15043; Q3ZTL7; Q3ZTL8; Q4VXS1; Q4VXS2; Q4VXV8; Q4VXV9; Q96D72; Q9BQW0; Q9BW03; Q9H4G6; Q9H4G7; Q9NTU8; Q9NUM8; Q9UFB6; DIDO1_HUMAN
Genbank Protein ID AAS49898.1; AAS49899.1; BAA20791.2; BAA92094.1; CAI95707.1; CAI95707.1; CAO03650.1; CAO03650.1; CAI95769.2; CAI95769.2; CAI95761.1; CAI95761.1; CAI95708.1; CAI95708.1; CAI95762.1; CAI95762.1; CAI95770.2; CAI95770.2; CAM28273.1; CAM28273.1; EAW75322.1; EAW75323.1; AAH00770.1; AAH04237.1; AAH14489.1; AAI37178.1; CAB61387.1
Protein Name Death-inducer obliterator 1; Death-associated transcription factor 1
Genbank Nucleotide ID AY481571; AY481572; AB002331; AK002127; AL117379; AL035669; AL117379; AL035669; AL035669; AL117379; AL035669; AL117379; AL117379; AL035669; AL035669; AL117379; AL035669; AL117379; AL117379; AL035669; CH471077; CH471077; BC000770; BC004237; BC012757; BC137177; AL133063
Gene Name DIDO1; C20orf158; DATF1; KIAA0333
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000101191.16 ENST00000395343.5 ENSP00000378752.1
ENSG00000101191.16 ENST00000395340.5 ENSP00000378749.1
ENSG00000101191.16 ENST00000370371.8 ENSP00000359397.4
ENSG00000101191.16 ENST00000370366.1 ENSP00000359391.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 4.00e-08 35.0 270 320
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 3    vClvCgeggedekslveCekCrewfHpaClkls...veeelpnsekwiCpkCr 52
           +C +C++++++ + +++C++C+ewfH +C+++s        +n e++iCp+C+
   Q: 270  YC-ICRQPHNN-RFMICCDRCEEWFHGDCVGISearGRLLERNGEDYICPNCT 320
           89.*******5.58999999*************7654444567777******6 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Isoform 2: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes.
 Isoform 2: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes.
Protein Sequence
(Fasta)
MDDKGDPSNE EAPKAIKPTS KEFRKTWGFR RTTIAKREGA GDAEADPLEP PPPQQQLGLS 60
LRRSGRQPKR TERVEQFLTI ARRRGRRSMP VSLEDSGEPT SCPATDAETA SEGSVESASE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046225|E3,PHD|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTACTTGCGC AGAACTCCCC TCGCGGCGAC CACGCACTAC GGGTTGGCGC CAGAGTCAAA 60
AGGCGTCGGC CCTCTGGCAA GATGGCTGCT GCGGAGGCGT TGGAGCGCGG AAATCTGGAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046225|E3,PHD|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR033082--DIDO1
IPR012921--SPOC_C
IPR003618--TFIIS_cen_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51321--TFIIS_CENTRAL
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF00628--PHD
PF07744--SPOC
PF07500--TFIIS_M
SMART

SM00249--PHD
SM00510--TFS2M
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005819--C:spindle
GO:0003723--F:RNA binding
GO:0008270--F:zinc ion binding
GO:0097190--P:apoptotic signaling pathway
GO:0006351--P:transcription, DNA-templated
KEGG hsa:11083
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001202 Ailuropoda melanoleuca 76.84 0.00e+00 1820.00
IUUC-Apl-003835 Anas platyrhynchos 66.36 2.00e-174 606.00
IUUC-Aca-004562 Anolis carolinensis 52.95 0.00e+00 1738.00
IUUC-Acl-008106 Aspergillus clavatus 34.15 5.00e-12 67.00
IUUC-Ani-009326 Aspergillus nidulans 53.57 7.00e-14 72.80
IUUC-Bta-013233 Bos taurus 70.86 0.00e+00 2227.00
IUUC-Cja-019811 Callithrix jacchus 91.89 0.00e+00 825.00
IUUC-Cfa-021034 Canis familiaris 77.84 0.00e+00 1661.00
IUUC-Cpo-021803 Cavia porcellus 72.74 0.00e+00 2498.00
IUUC-Csa-023686 Chlorocebus sabaeus 95.94 0.00e+00 3283.00
IUUC-Csv-026099 Ciona savignyi 65.45 3.00e-23 102.00
IUUC-Cgl-026411 Colletotrichum gloeosporioides 55.56 7.00e-15 75.10
IUUC-Dre-028475 Danio rerio 61.67 4.00e-59 222.00
IUUC-Dno-029513 Dasypus novemcinctus 80.82 0.00e+00 1610.00
IUUC-Dor-030833 Dipodomys ordii 69.80 0.00e+00 2069.00
IUUC-Dse-031262 Dothistroma septosporum 55.77 1.00e-14 75.50
IUUC-Ete-032750 Echinops telfairi 64.07 0.00e+00 849.00
IUUC-Fal-036812 Ficedula albicollis 54.57 0.00e+00 1213.00
IUUC-Fox-037812 Fusarium oxysporum 47.06 1.00e-12 67.80
IUUC-Fso-038446 Fusarium solani 50.00 2.00e-13 70.50
IUUC-Ggr-039960 Gaeumannomyces graminis 50.00 2.00e-13 70.90
IUUC-Gga-040620 Gallus gallus 66.06 5.00e-176 610.00
IUUC-Gac-041527 Gasterosteus aculeatus 45.33 0.00e+00 676.00
IUUC-Ggo-044747 Gorilla gorilla 99.11 0.00e+00 3496.00
IUUC-Itr-048422 Ictidomys tridecemlineatus 75.56 0.00e+00 2746.00
IUUC-Kpa-049206 Komagataella pastoris 27.97 6.00e-08 53.10
IUUC-Lch-050039 Latimeria chalumnae 47.68 0.00e+00 783.00
IUUC-Laf-053940 Loxodonta africana 71.46 0.00e+00 2407.00
IUUC-Mcc-055809 Macaca mulatta 96.34 0.00e+00 3324.00
IUUC-Mor-057044 Magnaporthe oryzae 50.00 7.00e-13 68.90
IUUC-Mpo-057588 Magnaporthe poae 50.00 3.00e-13 70.50
IUUC-Mga-060017 Meleagris gallopavo 57.26 0.00e+00 1867.00
IUUC-Mmr-061055 Microcebus murinus 77.57 0.00e+00 2624.00
IUUC-Mdo-062683 Monodelphis domestica 72.32 0.00e+00 1577.00
IUUC-Mmu-064010 Mus musculus 72.72 0.00e+00 2479.00
IUUC-Mac-064704 Musa acuminata 57.58 8.00e-10 58.20
IUUC-Mpu-066844 Mustela putorius furo 75.52 0.00e+00 1655.00
IUUC-Mlu-067160 Myotis lucifugus 71.23 0.00e+00 2458.00
IUUC-Nle-070068 Nomascus leucogenys 97.68 0.00e+00 3452.00
IUUC-Ont-072366 Oreochromis niloticus 43.81 2.00e-149 525.00
IUUC-Oan-072746 Ornithorhynchus anatinus 68.58 0.00e+00 1299.00
IUUC-Ocu-074336 Oryctolagus cuniculus 75.84 0.00e+00 1444.00
IUUC-Ogl-076925 Oryza glaberrima 43.64 1.00e-10 60.80
IUUC-Ola-086406 Oryzias latipes 45.93 2.00e-129 458.00
IUUC-Oga-088506 Otolemur garnettii 83.93 0.00e+00 1904.00
IUUC-Ptr-091448 Pan troglodytes 98.30 0.00e+00 3433.00
IUUC-Pan-092481 Papio anubis 96.33 0.00e+00 2042.00
IUUC-Psi-092995 Pelodiscus sinensis 58.40 0.00e+00 1625.00
IUUC-Pab-098673 Pongo abelii 98.48 0.00e+00 3456.00
IUUC-Rno-105243 Rattus norvegicus 72.14 0.00e+00 2513.00
IUUC-Sha-107260 Sarcophilus harrisii 74.06 0.00e+00 1637.00
IUUC-Sja-107904 Schizosaccharomyces japonicus 31.07 2.00e-14 74.70
IUUC-Stu-112199 Solanum tuberosum 36.49 2.00e-11 63.90
IUUC-Tgu-117059 Taeniopygia guttata 54.61 0.00e+00 1222.00
IUUC-Tru-117650 Takifugu rubripes 48.95 1.00e-131 465.00
IUUC-Tre-122185 Trichoderma reesei 60.78 1.00e-15 77.40
IUUC-Tvi-122269 Trichoderma virens 58.82 7.00e-15 75.10
IUUC-Ttr-129315 Tursiops truncatus 73.11 0.00e+00 1614.00
IUUC-Vpa-130265 Vicugna pacos 66.87 2.00e-113 404.00
IUUC-Xma-133754 Xiphophorus maculatus 43.90 1.00e-134 475.00
Created Date 25-Jun-2017

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