iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074465

UUCD1 version

UUC-OrC-00238

Ensembl Protein ID

ENSOCUP00000005403.2

UniProt Accession

G1SQL9; G1SQL9_RABIT

Protein Name

Uncharacterized protein

Gene Name

FBXO18

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000006237.3	ENSOCUT00000006243.2	ENSOCUP00000005403.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	90.65	0.00e+00	1864.00	IUUC-Hsa-046650
E3 adaptor/Cullin RING/SCF/F-box	29.05	1.00e-42	169.00	IUUC-Spo-108147

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

VRRFKRKQLT AIDCQHLAQS HLSVTQPFCQ RWTNRDPNHG LYPRPRTKRG RRGQGCQRHN 60
SEFFLAGQQQ CTNDMAKSSS VGQDSYQDSE SDMIVPAESS CSLPQRGDRE VRLGSSGSAL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGAGACGGT TTAAGCGGAA GCAGCTAACA GCCATCGACT GCCAACATTT GGCTCAGAGT 60
CACTTGTCTG TGACCCAGCC CTTCTGTCAG AGATGGACAA ACAGAGATCC GAACCATGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR014017--DNA_helicase_UvrD-like_C
IPR000212--DNA_helicase_UvrD/REP
IPR001810--F-box_dom
IPR027417--P-loop_NTPase

PROSITE

PS50181--FBOX

Pfam

PF12937--F-box-like
PF13361--UvrD_C

SMART

SM00256--FBOX

Gene Ontology

GO:0000785--C:chromatin
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0043138--F:3'-5' DNA helicase activity
GO:0005524--F:ATP binding
GO:0004003--F:ATP-dependent DNA helicase activity
GO:0015616--F:DNA translocase activity
GO:0003690--F:double-stranded DNA binding
GO:0003697--F:single-stranded DNA binding
GO:0008219--P:cell death
GO:0006974--P:cellular response to DNA damage stimulus
GO:0000737--P:DNA catabolic process, endonucleolytic
GO:0035562--P:negative regulation of chromatin binding
GO:2000042--P:negative regulation of double-strand break repair via homologous recombination
GO:1902231--P:positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0001934--P:positive regulation of protein phosphorylation
GO:0016567--P:protein ubiquitination
GO:0031297--P:replication fork processing
GO:0048478--P:replication fork protection
GO:0072429--P:response to intra-S DNA damage checkpoint signaling

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000424	Aegilops tauschii	47.83	2.00e-05	45.10
IUUC-Aml-001396	Ailuropoda melanoleuca	90.17	0.00e+00	1883.00
IUUC-Atr-002826	Amborella trichopoda	41.27	6.00e-04	40.40
IUUC-Apl-003317	Anas platyrhynchos	48.65	0.00e+00	915.00
IUUC-Aca-004498	Anolis carolinensis	53.41	0.00e+00	923.00
IUUC-Aly-006174	Arabidopsis lyrata	32.79	3.00e-04	37.40
IUUC-Ath-007293	Arabidopsis thaliana	37.68	4.00e-03	37.70
IUUC-Ani-009226	Aspergillus nidulans	34.74	4.00e-05	44.30
IUUC-Ate-010526	Aspergillus terreus	39.71	5.00e-04	40.00
IUUC-Ame-011808	Astyanax mexicanus	57.82	1.00e-129	456.00
IUUC-Bta-013250	Bos taurus	87.40	0.00e+00	1839.00
IUUC-Bol-015348	Brassica oleracea	37.68	3.00e-03	38.10
IUUC-Cja-019638	Callithrix jacchus	90.55	0.00e+00	1939.00
IUUC-Cfa-020195	Canis familiaris	91.79	0.00e+00	1810.00
IUUC-Cpo-022269	Cavia porcellus	86.30	0.00e+00	1769.00
IUUC-Cre-022611	Chlamydomonas reinhardtii	40.28	3.00e-08	54.30
IUUC-Csa-024060	Chlorocebus sabaeus	91.79	0.00e+00	1728.00
IUUC-Cho-025003	Choloepus hoffmanni	90.40	0.00e+00	709.00
IUUC-Cin-025694	Ciona intestinalis	27.13	5.00e-28	118.00
IUUC-Dre-028083	Danio rerio	45.37	0.00e+00	867.00
IUUC-Dno-029203	Dasypus novemcinctus	86.31	0.00e+00	1736.00
IUUC-Dor-030477	Dipodomys ordii	96.43	0.00e+00	773.00
IUUC-Ete-032861	Echinops telfairi	87.21	0.00e+00	1821.00
IUUC-Eca-033205	Equus caballus	91.15	0.00e+00	1954.00
IUUC-Eeu-034784	Erinaceus europaeus	84.77	0.00e+00	1164.00
IUUC-Fca-035797	Felis catus	90.48	0.00e+00	1900.00
IUUC-Gmo-038855	Gadus morhua	45.92	1.00e-119	424.00
IUUC-Gga-040326	Gallus gallus	50.38	0.00e+00	956.00
IUUC-Gac-042240	Gasterosteus aculeatus	40.92	0.00e+00	709.00
IUUC-Ggo-045050	Gorilla gorilla	87.19	0.00e+00	1785.00
IUUC-Hsa-046650	Homo sapiens	90.55	0.00e+00	1877.00
IUUC-Itr-047965	Ictidomys tridecemlineatus	95.40	0.00e+00	756.00
IUUC-Lch-050231	Latimeria chalumnae	49.11	3.00e-156	545.00
IUUC-Loc-051884	Lepisosteus oculatus	48.78	0.00e+00	955.00
IUUC-Lma-053267	Leptosphaeria maculans	22.25	1.00e-03	39.30
IUUC-Laf-053843	Loxodonta africana	89.12	0.00e+00	1881.00
IUUC-Mcc-055570	Macaca mulatta	90.84	0.00e+00	1900.00
IUUC-Meu-056798	Macropus eugenii	66.67	1.00e-146	514.00
IUUC-Mtr-057915	Medicago truncatula	36.76	5.00e-04	40.80
IUUC-Mga-059648	Meleagris gallopavo	50.81	0.00e+00	914.00
IUUC-Mmr-060757	Microcebus murinus	89.02	0.00e+00	1817.00
IUUC-Mdo-061913	Monodelphis domestica	68.72	0.00e+00	1343.00
IUUC-Mmu-064337	Mus musculus	88.17	0.00e+00	1879.00
IUUC-Mac-064479	Musa acuminata	38.71	6.00e-03	36.60
IUUC-Mpu-066483	Mustela putorius furo	88.84	0.00e+00	1897.00
IUUC-Mlu-068204	Myotis lucifugus	84.06	0.00e+00	1764.00
IUUC-Ncr-068735	Neurospora crassa	37.50	3.00e-03	37.70
IUUC-Nle-070053	Nomascus leucogenys	90.74	0.00e+00	1843.00
IUUC-Opr-070588	Ochotona princeps	88.17	0.00e+00	1842.00
IUUC-Ont-072655	Oreochromis niloticus	46.43	0.00e+00	734.00
IUUC-Oan-073351	Ornithorhynchus anatinus	62.26	0.00e+00	1283.00
IUUC-Oin-079176	Oryza indica	23.33	6.00e-04	38.90
IUUC-Opu-083155	Oryza punctata	50.00	2.00e-03	38.50
IUUC-Olu-087831	Ostreococcus lucimarinus	31.30	5.00e-64	240.00
IUUC-Oga-089088	Otolemur garnettii	87.98	0.00e+00	1795.00
IUUC-Oar-089870	Ovis aries	87.02	0.00e+00	1801.00
IUUC-Ptr-090957	Pan troglodytes	90.74	0.00e+00	1852.00
IUUC-Pan-092632	Papio anubis	91.21	0.00e+00	1862.00
IUUC-Psi-093035	Pelodiscus sinensis	54.67	0.00e+00	1101.00
IUUC-Pno-094870	Phaeosphaeria nodorum	24.20	7.00e-04	39.70
IUUC-Ppa-095660	Physcomitrella patens	38.36	5.00e-04	40.80
IUUC-Pfo-096902	Poecilia formosa	44.48	0.00e+00	660.00
IUUC-Pab-098206	Pongo abelii	90.93	0.00e+00	1746.00
IUUC-Pop-098801	Populus trichocarpa	34.72	5.00e-04	40.40
IUUC-Pca-100238	Procavia capensis	83.78	0.00e+00	1745.00
IUUC-Ppe-101748	Prunus persica	35.94	6.00e-03	37.00
IUUC-Pva-103182	Pteropus vampyrus	87.79	0.00e+00	1809.00
IUUC-Pte-104033	Pyrenophora teres	22.75	4.00e-04	40.80
IUUC-Pyt-104599	Pyrenophora triticirepentis	23.66	3.00e-04	40.80
IUUC-Rno-105141	Rattus norvegicus	87.88	0.00e+00	1874.00
IUUC-Sce-106341	Saccharomyces cerevisiae	25.76	2.00e-03	37.40
IUUC-Sha-106827	Sarcophilus harrisii	66.98	0.00e+00	1416.00
IUUC-Sja-107882	Schizosaccharomyces japonicus	28.83	6.00e-44	172.00
IUUC-Spo-108147	Schizosaccharomyces pombe	29.05	2.00e-42	167.00
IUUC-Ssl-108584	Sclerotinia sclerotiorum	26.19	1.00e-03	39.30
IUUC-Sly-111170	Solanum lycopersicum	33.33	4.70e-02	33.10
IUUC-Sre-115025	Sporisorium reilianum	32.82	2.00e-38	154.00
IUUC-Ssc-116188	Sus scrofa	92.93	0.00e+00	1228.00
IUUC-Tgu-116612	Taeniopygia guttata	57.56	3.00e-156	544.00
IUUC-Tsy-119560	Tarsius syrichta	82.66	1.00e-114	407.00
IUUC-Tni-120734	Tetraodon nigroviridis	45.55	0.00e+00	696.00
IUUC-Tca-121338	Theobroma cacao	30.36	7.00e-03	36.60
IUUC-Tre-122089	Trichoderma reesei	40.74	3.00e-04	40.80
IUUC-Tme-127009	Tuber melanosporum	25.93	3.00e-04	40.80
IUUC-Tbe-127431	Tupaia belangeri	89.62	0.00e+00	1612.00
IUUC-Ttr-128744	Tursiops truncatus	86.46	0.00e+00	1787.00
IUUC-Uma-129536	Ustilago maydis	32.77	1.00e-40	162.00
IUUC-Vpa-130123	Vicugna pacos	72.33	2.00e-97	350.00
IUUC-Vvi-131025	Vitis vinifera	37.50	3.00e-03	37.70
IUUC-Xtr-132902	Xenopus tropicalis	52.63	0.00e+00	1034.00
IUUC-Xma-133978	Xiphophorus maculatus	45.54	2.00e-146	513.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence