iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ssc-115899

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

CR956379

Gene Name

CUL7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000001657.2	ENSSSCT00000001847.2	ENSSSCP00000001800.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	6.20e-122	408.6	1019	1570

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 70   nreWekfreqlkvlrkifayldrtyvkkskkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveL 156
            ++W+ f e l+ ++++f      y+++           +++w+++i+ed +++ll+l+++l+ a+R+++++++r+l++ +++    
   Q: 1019 PTFWPVFWELLCHHTRLF------YMVR-----------AQTWSQDIAED-RRSLLHLSSRLNGALRHEQNFANRFLPDNEAA---- 1083
           689***************......****...........***********.********************************.... PP
   S: 157  slnklaiykesFEakfleatqefykaesaeflqe.nevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllae 242
               +a++k+++Ea++++ +q++++++++ ++   + +d+Yl+ ++a++n+++++aa++++++++t+Ll++ve+++++       a 
   Q: 1084 ----QALGKSCWEALVSPLVQNVTSPDEDGISPMgWLLDQYLESRDAAYNPQSRAAAFSSRVRRLTNLLVHVEPCEAS----PTAAS 1162
           ....9*************************************************************************....55677 PP
   S: 243  lvallrdkktedlsrmykLlsrvln..gleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlk 327
            ++ +  +++++ +++++L++++l+  ++++l+++++++++e+++ +lt+ ++++d   +V+r++++++ lqk++se+F+++a+Fl 
   Q: 1163 APSPVSTEGRNRSHDWSSLATQGLPssIMRNLTRCWQAFVEEKVNSFLTSRWQDDD---FVPRYCDHFHNLQKSSSELFGPRAAFLL 1246
           8888899*****************999*****************************...**************************** PP
   S: 328  aldkafetfvnknsvlkaakspEllAryiDqlLrks.skglteeeleaqldkvllvfkyisekdv...FekyYkkhLakRLlsgksa 410
           al+++++ ++++ ++lkaa+++E++Ar+iDq +r+s ++g++   ++aql+++l+ + ++s++++   Fe+yY++++ +R      +
   Q: 1247 ALQNGCAGALLRLPFLKAAHVSEQFARHIDQCIRGSrNGGPQ--GMLAQLQQCLESVLIFSGLEIattFEHYYQHYMVDRVFA-VGF 1330
           ************************************777776..589*********************************999.99* PP
   S: 411  sseaEesviekLkeecgaeftskL.erMfqdlkvSedlnrqFk............................................ 452
           ss++Ee  + ++    g++f+++L ++ f++l++Se+ +rqF+                                            
   Q: 1331 SSWLEEVALDQI----GPCFPNRLpQQIFRSLSTSEERQRQFHvyqlqrldqqllklegterkiqvgceasgrghtrgngeeeavaa 1413
           ************....*********************************************************************** PP
   S: 453  ................eekenteesesvelsvlvLsagaWptaset..ekvsLPaelektiekfeefY........lekhsgRkLqW 513
                           ++++ ++e +++e+svlvL+ +     ++   ++++LPa+l++t++++++fY        le++++R+LqW
   Q: 1414 iaeeaekeeddnededDNEDLYYEGAMPEMSVLVLNGSPTGSICHPlnPRTCLPAYLRDTLNRYSNFYikshsypaLERGPHRRLQW 1500
           ***************999999***************875555554446*************************************** PP
   S: 514  qhtlgraelkaelkkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvsskkqvlkkepe 588
           ++ lgra l++    g ++lqV+t+Qm++LL++n+ ++vsve l + ++l++++L+ ++ +L+ss+  +  +ep+
   Q: 1501 TW-LGRAVLQF----GDQTLQVTTVQMWLLLHLNELQAVSVERLLALSGLSPDVLNWAIRPLASSRGPLELHEPK 1570
           **.********....**************************************************9655556665 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

PARHAPSRLP ASTPYWGPSA GMAGELHYRE FRVPLGPGLH AYPDELIRQR VGRDGHPEYQ 60
IRWLILQRGD DGEGGSNQVD CKAEHILLWM SNDEIYANCH KMLDKDGRVI GPSQETAGEA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCGCGCGCC ACGCCCCCTC CCGCCTCCCC GCCTCGACCC CTTACTGGGG GCCCAGGCGG 60
GGCCCAAATC TCCGCAGGCG CCGCCGCCAT CGTCTGTGCC GCGTCCCTAG CTCGGCGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR004939--APC_su10/DOC_dom
IPR016024--ARM-type_fold
IPR021097--CPH_domain
IPR031223--CUL7
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR008979--Galactose-bd-like
IPR014722--Rib_L2_dom2
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50069--CULLIN_2
PS51284--DOC

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00888--Cullin

SMART

SM01337--APC10
SM00884--Cullin_Nedd8

Gene Ontology

GO:1990393--C:3M complex
GO:0005813--C:centrosome
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0001837--P:epithelial to mesenchymal transition
GO:0000226--P:microtubule cytoskeleton organization
GO:0000281--P:mitotic cytokinesis
GO:0001890--P:placenta development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0016567--P:protein ubiquitination
GO:0007088--P:regulation of mitotic nuclear division
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0001570--P:vasculogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002360	Ailuropoda melanoleuca	82.42	0.00e+00	2606.00
IUUC-Bta-013285	Bos taurus	84.27	0.00e+00	2646.00
IUUC-Cja-019033	Callithrix jacchus	78.20	0.00e+00	2446.00
IUUC-Cfa-020695	Canis familiaris	81.67	0.00e+00	1603.00
IUUC-Cpo-021513	Cavia porcellus	73.92	0.00e+00	2310.00
IUUC-Csa-023798	Chlorocebus sabaeus	81.26	0.00e+00	2529.00
IUUC-Dor-030234	Dipodomys ordii	77.24	0.00e+00	2530.00
IUUC-Ete-032612	Echinops telfairi	70.68	0.00e+00	783.00
IUUC-Eca-033408	Equus caballus	84.09	0.00e+00	2575.00
IUUC-Fca-035483	Felis catus	84.23	0.00e+00	2647.00
IUUC-Gac-041628	Gasterosteus aculeatus	46.29	0.00e+00	1091.00
IUUC-Ggo-044721	Gorilla gorilla	81.55	0.00e+00	2544.00
IUUC-Hsa-046406	Homo sapiens	81.55	0.00e+00	2571.00
IUUC-Itr-048525	Ictidomys tridecemlineatus	80.86	0.00e+00	2529.00
IUUC-Lch-049956	Latimeria chalumnae	43.06	0.00e+00	999.00
IUUC-Laf-054068	Loxodonta africana	80.95	0.00e+00	2577.00
IUUC-Mcc-055464	Macaca mulatta	81.37	0.00e+00	2512.00
IUUC-Meu-056198	Macropus eugenii	52.99	0.00e+00	1248.00
IUUC-Mmr-061464	Microcebus murinus	82.87	0.00e+00	2532.00
IUUC-Mdo-062018	Monodelphis domestica	56.18	0.00e+00	1326.00
IUUC-Mmu-063413	Mus musculus	72.23	0.00e+00	2210.00
IUUC-Mpu-066146	Mustela putorius furo	82.72	0.00e+00	2535.00
IUUC-Mlu-067036	Myotis lucifugus	82.87	0.00e+00	2636.00
IUUC-Opr-070670	Ochotona princeps	72.24	0.00e+00	2268.00
IUUC-Oan-073451	Ornithorhynchus anatinus	50.40	0.00e+00	1123.00
IUUC-Ocu-074155	Oryctolagus cuniculus	78.33	0.00e+00	2424.00
IUUC-Oga-089084	Otolemur garnettii	82.49	0.00e+00	2624.00
IUUC-Oar-090029	Ovis aries	83.84	0.00e+00	2638.00
IUUC-Ptr-091282	Pan troglodytes	82.17	0.00e+00	2619.00
IUUC-Pan-091883	Papio anubis	81.26	0.00e+00	2536.00
IUUC-Pab-098383	Pongo abelii	80.34	0.00e+00	2503.00
IUUC-Pca-100519	Procavia capensis	75.12	0.00e+00	787.00
IUUC-Pva-102417	Pteropus vampyrus	81.37	0.00e+00	2058.00
IUUC-Rno-105962	Rattus norvegicus	73.86	0.00e+00	2318.00
IUUC-Tsy-118860	Tarsius syrichta	79.69	0.00e+00	1023.00
IUUC-Tbe-127660	Tupaia belangeri	81.26	0.00e+00	1346.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence