iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-050301

Ensembl Protein ID

ENSLACP00000012631.1

UniProt Accession

H3ASL0; H3ASL0_LATCH

Genbank Protein ID

ENSLACP00000012631

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AFYH01157729

Gene Name

HERC3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000011128.1	ENSLACT00000012725.1	ENSLACP00000012631.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.70e-95	320.5	725	1048

Active Site

Position(s)	Description	Evidence
1017	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           dlkk l+v f gEe++d+gGvt+ef+ ll+kel +p +g+f+y ++++  ++ ++        + ++F+++G+++g+a+++  ++d+
   Q: 725  DLKKPLKVIFDGEEAVDAGGVTKEFFLLLIKELLDPIYGMFTYYKESNVLWFSEKCFV-----EHNWFHLIGIMCGLAIYNFTVVDM 806
           899***********************************************99877665.....579********************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll++k +ledl+e+ p+  +sl++++++  +d+e++ ++ltfs+  e++g t+++eL+pgG++  V +eN++e+v+++
   Q: 807  HFPLVLYKKLLNVKPTLEDLKELSPTEGRSLQQLLDYPGDDVEDT-FCLTFSICRESYGVTEVKELVPGGNKLTVRKENRQEFVDAY 892
           *************************************99999998.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y++ ++++e ++ f++Gf +v+  ++l+lF+++el+ ++ G++++++++l+k++ ykg+y+e++p++++Fw+v++ef  e++k+f
   Q: 893  VNYTFSSSVQEWYQPFSSGFLKVCGGKVLQLFQPSELRAMVVGNNNYNWQQLEKNAVYKGEYSETHPTVKMFWDVFHEFPLEKKKQF 979
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+ +l+   ++i+  +  ++ lP ++TC+n+L+LP+Y +ke+l+ +L+ Ai++ +gF+l
   Q: 980  LLFLTGSDRIPIYGMGSLR---IIIQSmSVGEQYLPVAHTCYNLLDLPKYRTKETLRTRLTQAIDHYEGFSL 1048
           *******************...7777768899**************************************97 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MLCWGHGANG QLGMEEALDV VAEAQVCKFF NGRLVKEVAC GGYHSVFLQN DGSVYTCGSS 60
TEGQLGHEKG GYKPEQVTNL SAQNIVHVAC GRAHSLAVND KGQVFSWGAG SDGQLGHGSA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNGTGTGT 60
GTGTGGGGGG GGTGAAGAAG GGAGTTGGGT TTCCAATTCG GACGTGCTGA CGTTGCCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

KEGG

lcm:102354260

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001673	Ailuropoda melanoleuca	73.90	0.00e+00	1592.00
IUUC-Apl-003535	Anas platyrhynchos	74.19	0.00e+00	1594.00
IUUC-Aca-005223	Anolis carolinensis	72.57	0.00e+00	1556.00
IUUC-Ame-010816	Astyanax mexicanus	68.69	0.00e+00	1214.00
IUUC-Bta-013373	Bos taurus	73.71	0.00e+00	1591.00
IUUC-Cel-018150	Caenorhabditis elegans	34.02	2.00e-160	559.00
IUUC-Cja-019609	Callithrix jacchus	73.52	0.00e+00	1583.00
IUUC-Cfa-021071	Canis familiaris	73.81	0.00e+00	1586.00
IUUC-Cpo-021548	Cavia porcellus	72.76	0.00e+00	1569.00
IUUC-Csa-023987	Chlorocebus sabaeus	73.43	0.00e+00	1581.00
IUUC-Cho-024325	Choloepus hoffmanni	79.27	0.00e+00	999.00
IUUC-Cin-025232	Ciona intestinalis	41.39	0.00e+00	778.00
IUUC-Dre-027472	Danio rerio	68.64	0.00e+00	1450.00
IUUC-Dno-029241	Dasypus novemcinctus	73.10	0.00e+00	1568.00
IUUC-Dor-030672	Dipodomys ordii	63.56	0.00e+00	777.00
IUUC-Dme-032103	Drosophila melanogaster	43.48	0.00e+00	862.00
IUUC-Ete-032642	Echinops telfairi	70.48	0.00e+00	1457.00
IUUC-Eca-033646	Equus caballus	73.14	0.00e+00	1573.00
IUUC-Eeu-035098	Erinaceus europaeus	67.56	0.00e+00	1109.00
IUUC-Fal-036952	Ficedula albicollis	74.38	0.00e+00	1595.00
IUUC-Gmo-039297	Gadus morhua	66.60	0.00e+00	1373.00
IUUC-Gga-040591	Gallus gallus	73.55	0.00e+00	1577.00
IUUC-Gac-041741	Gasterosteus aculeatus	66.95	0.00e+00	1440.00
IUUC-Ggo-044769	Gorilla gorilla	73.36	0.00e+00	1576.00
IUUC-Hsa-046066	Homo sapiens	73.43	0.00e+00	1579.00
IUUC-Itr-048311	Ictidomys tridecemlineatus	73.26	0.00e+00	1575.00
IUUC-Loc-052803	Lepisosteus oculatus	68.91	0.00e+00	1511.00
IUUC-Laf-053364	Loxodonta africana	73.43	0.00e+00	1578.00
IUUC-Mcc-054930	Macaca mulatta	73.33	0.00e+00	1582.00
IUUC-Meu-056274	Macropus eugenii	58.72	0.00e+00	632.00
IUUC-Mga-059563	Meleagris gallopavo	73.90	0.00e+00	1591.00
IUUC-Mmr-060792	Microcebus murinus	72.10	0.00e+00	1540.00
IUUC-Mdo-062195	Monodelphis domestica	74.12	0.00e+00	1593.00
IUUC-Mmu-063855	Mus musculus	72.29	0.00e+00	1567.00
IUUC-Mpu-066308	Mustela putorius furo	73.71	0.00e+00	1587.00
IUUC-Mlu-066927	Myotis lucifugus	73.33	0.00e+00	1578.00
IUUC-Nle-070090	Nomascus leucogenys	73.62	0.00e+00	1584.00
IUUC-Opr-070891	Ochotona princeps	64.29	0.00e+00	1324.00
IUUC-Ont-072201	Oreochromis niloticus	65.56	0.00e+00	1399.00
IUUC-Ocu-074770	Oryctolagus cuniculus	73.62	0.00e+00	1583.00
IUUC-Ola-086550	Oryzias latipes	66.29	0.00e+00	1428.00
IUUC-Olu-087836	Ostreococcus lucimarinus	35.05	4.00e-42	164.00
IUUC-Oga-088831	Otolemur garnettii	73.05	0.00e+00	1569.00
IUUC-Oar-090449	Ovis aries	73.81	0.00e+00	1585.00
IUUC-Pan-092135	Papio anubis	73.55	0.00e+00	1580.00
IUUC-Psi-093832	Pelodiscus sinensis	73.07	0.00e+00	1590.00
IUUC-Pfo-097268	Poecilia formosa	66.00	0.00e+00	1426.00
IUUC-Pab-098249	Pongo abelii	73.24	0.00e+00	1575.00
IUUC-Pca-100855	Procavia capensis	67.21	0.00e+00	1027.00
IUUC-Pva-102506	Pteropus vampyrus	66.60	0.00e+00	1377.00
IUUC-Rno-105242	Rattus norvegicus	72.38	0.00e+00	1604.00
IUUC-Sar-113612	Sorex araneus	79.23	0.00e+00	629.00
IUUC-Ssc-115473	Sus scrofa	73.62	0.00e+00	1581.00
IUUC-Tgu-116974	Taeniopygia guttata	74.22	0.00e+00	1575.00
IUUC-Tru-118077	Takifugu rubripes	64.52	0.00e+00	1355.00
IUUC-Tsy-119619	Tarsius syrichta	64.00	0.00e+00	1376.00
IUUC-Tni-120807	Tetraodon nigroviridis	65.12	0.00e+00	1384.00
IUUC-Tbe-127640	Tupaia belangeri	71.14	0.00e+00	1481.00
IUUC-Ttr-129172	Tursiops truncatus	73.43	0.00e+00	1572.00
IUUC-Vpa-130442	Vicugna pacos	62.31	0.00e+00	1285.00
IUUC-Xtr-132194	Xenopus tropicalis	64.67	0.00e+00	1297.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence