iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aca-004724

Ensembl Protein ID

ENSACAP00000008770.2

UniProt Accession

H9GEL5; H9GEL5_ANOCA

Protein Name

Tyrosine-protein kinase

Gene Name

HCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000008823.3	ENSACAT00000008958.3	ENSACAP00000008770.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	7.80e-17	60.9	60	117

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++v +lydy+a ++++L+++kGd ++v+   e++++W+k+++  +gk G++P+n+v++++
   Q: 60   DFVVLALYDYDAIHTEDLSFRKGDHLKVL---EESGEWWKAKSLSNGKVGFIPSNYVARVD 117
           57899************************...99*************************97 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

LPRMGCIKSK EHGLQRKTSK THSSSSLQGH YVKDPTSKPF ILECRFCEFM PFLVLTGLED 60
FVVLALYDYD AIHTEDLSFR KGDHLKVLEE SGEWWKAKSL SNGKVGFIPS NYVARVDSLE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCCCAGGA TGGGCTGCAT CAAGTCTAAA GAGCACGGCC TTCAACGAAA GACATCCAAA 60
ACCCATTCAA GCTCCAGCCT CCAAGGCCAT TATGTCAAAG ATCCGACATC CAAGCCGTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001284	Ailuropoda melanoleuca	77.93	0.00e+00	790.00
IUUC-Apl-003285	Anas platyrhynchos	78.75	0.00e+00	797.00
IUUC-Ame-011954	Astyanax mexicanus	74.85	0.00e+00	738.00
IUUC-Bta-013060	Bos taurus	77.04	0.00e+00	786.00
IUUC-Cja-019817	Callithrix jacchus	77.21	0.00e+00	783.00
IUUC-Cfa-020511	Canis familiaris	78.67	0.00e+00	795.00
IUUC-Cpo-022538	Cavia porcellus	77.80	0.00e+00	775.00
IUUC-Csa-024143	Chlorocebus sabaeus	77.21	0.00e+00	779.00
IUUC-Dre-028157	Danio rerio	75.49	0.00e+00	771.00
IUUC-Dno-029761	Dasypus novemcinctus	76.82	0.00e+00	776.00
IUUC-Eca-034090	Equus caballus	76.13	0.00e+00	760.00
IUUC-Fca-035937	Felis catus	76.92	0.00e+00	749.00
IUUC-Fal-036624	Ficedula albicollis	77.54	0.00e+00	793.00
IUUC-Gmo-039009	Gadus morhua	70.25	0.00e+00	728.00
IUUC-Gga-040296	Gallus gallus	75.49	0.00e+00	770.00
IUUC-Gac-042362	Gasterosteus aculeatus	75.25	0.00e+00	772.00
IUUC-Ggo-044570	Gorilla gorilla	77.45	0.00e+00	790.00
IUUC-Hsa-046378	Homo sapiens	77.65	0.00e+00	791.00
IUUC-Itr-048695	Ictidomys tridecemlineatus	77.17	0.00e+00	782.00
IUUC-Loc-052904	Lepisosteus oculatus	77.01	0.00e+00	793.00
IUUC-Laf-053654	Loxodonta africana	77.36	0.00e+00	781.00
IUUC-Mcc-055317	Macaca mulatta	77.56	0.00e+00	783.00
IUUC-Mga-060194	Meleagris gallopavo	78.81	0.00e+00	736.00
IUUC-Mmr-061510	Microcebus murinus	76.18	0.00e+00	783.00
IUUC-Mdo-062035	Monodelphis domestica	75.79	0.00e+00	769.00
IUUC-Mmu-064037	Mus musculus	76.62	0.00e+00	780.00
IUUC-Mpu-066874	Mustela putorius furo	77.60	0.00e+00	785.00
IUUC-Mlu-068202	Myotis lucifugus	75.10	0.00e+00	756.00
IUUC-Nle-069222	Nomascus leucogenys	78.04	0.00e+00	786.00
IUUC-Opr-070705	Ochotona princeps	74.71	0.00e+00	766.00
IUUC-Ont-072347	Oreochromis niloticus	81.92	0.00e+00	737.00
IUUC-Ocu-074490	Oryctolagus cuniculus	75.74	0.00e+00	771.00
IUUC-Ola-086521	Oryzias latipes	82.64	0.00e+00	768.00
IUUC-Oga-088153	Otolemur garnettii	76.27	0.00e+00	778.00
IUUC-Oar-090184	Ovis aries	76.16	0.00e+00	773.00
IUUC-Ptr-090505	Pan troglodytes	73.92	0.00e+00	738.00
IUUC-Pan-092260	Papio anubis	77.36	0.00e+00	782.00
IUUC-Pma-094311	Petromyzon marinus	71.02	0.00e+00	674.00
IUUC-Pfo-096566	Poecilia formosa	75.25	0.00e+00	775.00
IUUC-Pva-103021	Pteropus vampyrus	78.19	0.00e+00	791.00
IUUC-Rno-105309	Rattus norvegicus	76.73	0.00e+00	780.00
IUUC-Sha-107099	Sarcophilus harrisii	75.10	0.00e+00	771.00
IUUC-Stu-112331	Solanum tuberosum	30.83	1.00e-22	102.00
IUUC-Tgu-116912	Taeniopygia guttata	78.04	0.00e+00	791.00
IUUC-Tru-118449	Takifugu rubripes	81.21	0.00e+00	747.00
IUUC-Tbe-128144	Tupaia belangeri	74.39	0.00e+00	678.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence