iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003285

Ensembl Protein ID

ENSAPLP00000005240.1

UniProt Accession

U3IDB8; U3IDB8_ANAPL

Genbank Protein ID

ENSAPLP00000005240

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

ADON01014464

Gene Name

HCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000005638.1	ENSAPLT00000005870.1	ENSAPLP00000005240.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.90e-12	46.1	78	137

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfP....enFvekle 63
           +v +lydyea + ++L++kkG+ ++v+   e+ ++W+++ +  +g +G++P    +n+v++++
   Q: 78   VVLALYDYEALHAGDLSFKKGERLKVL---EEKGEWWQARSLVTGHEGFIPsyipSNYVARAD 137
           6889***********************...899***************975222279999876 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

TSNWSQCPCP GCPPGEGRAP WMGCVRSKEA DIQDKVIKTD LEPGLQLGRY VRDPTADNKQ 60
HNACSAVPLP ADGPGDSVVL ALYDYEALHA GDLSFKKGER LKVLEEKGEW WQARSLVTGH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCAGCAACT GGTCCCAGTG CCCGTGTCCA GGGTGTCCTC CTGGAGAGGG CCGCGCTCCC 60
TGCCCCTGTC GGCTCTGCTG CTGCCCCGGT GAGGGGTCTG GTGAAGGCTT TGGCGCACTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001284	Ailuropoda melanoleuca	78.41	0.00e+00	830.00
IUUC-Aca-004724	Anolis carolinensis	78.75	0.00e+00	803.00
IUUC-Ame-011954	Astyanax mexicanus	74.80	0.00e+00	754.00
IUUC-Bta-013060	Bos taurus	78.10	0.00e+00	829.00
IUUC-Bdi-014195	Brachypodium distachyon	29.97	5.00e-22	99.40
IUUC-Bra-016997	Brassica rapa	30.80	1.00e-20	95.50
IUUC-Cja-019817	Callithrix jacchus	77.84	0.00e+00	796.00
IUUC-Cfa-020511	Canis familiaris	79.43	0.00e+00	840.00
IUUC-Cpo-022538	Cavia porcellus	76.97	0.00e+00	792.00
IUUC-Csa-024143	Chlorocebus sabaeus	78.59	0.00e+00	804.00
IUUC-Dre-028157	Danio rerio	75.15	0.00e+00	790.00
IUUC-Dno-029761	Dasypus novemcinctus	78.74	0.00e+00	816.00
IUUC-Eca-034090	Equus caballus	76.85	0.00e+00	801.00
IUUC-Fca-035937	Felis catus	77.99	0.00e+00	801.00
IUUC-Fal-036624	Ficedula albicollis	85.35	0.00e+00	900.00
IUUC-Gmo-039009	Gadus morhua	71.34	0.00e+00	746.00
IUUC-Gga-040296	Gallus gallus	84.55	0.00e+00	890.00
IUUC-Gac-042362	Gasterosteus aculeatus	73.19	0.00e+00	768.00
IUUC-Ggo-044570	Gorilla gorilla	77.42	0.00e+00	823.00
IUUC-Hsa-046378	Homo sapiens	77.84	0.00e+00	827.00
IUUC-Hvu-047798	Hordeum vulgare	30.25	2.00e-21	97.10
IUUC-Itr-048695	Ictidomys tridecemlineatus	76.28	0.00e+00	807.00
IUUC-Loc-052904	Lepisosteus oculatus	77.54	0.00e+00	822.00
IUUC-Laf-053654	Loxodonta africana	79.33	0.00e+00	813.00
IUUC-Mcc-055317	Macaca mulatta	78.78	0.00e+00	811.00
IUUC-Mga-060194	Meleagris gallopavo	87.67	0.00e+00	833.00
IUUC-Mmr-061510	Microcebus murinus	77.10	0.00e+00	794.00
IUUC-Mdo-062035	Monodelphis domestica	76.18	0.00e+00	793.00
IUUC-Mmu-064037	Mus musculus	77.14	0.00e+00	831.00
IUUC-Mac-064532	Musa acuminata	32.19	1.00e-20	94.70
IUUC-Mpu-066874	Mustela putorius furo	79.37	0.00e+00	815.00
IUUC-Mlu-068202	Myotis lucifugus	73.35	0.00e+00	775.00
IUUC-Nle-069222	Nomascus leucogenys	78.39	0.00e+00	810.00
IUUC-Opr-070705	Ochotona princeps	75.71	0.00e+00	806.00
IUUC-Ont-072347	Oreochromis niloticus	80.31	0.00e+00	747.00
IUUC-Ocu-074490	Oryctolagus cuniculus	77.36	0.00e+00	796.00
IUUC-Oba-075219	Oryza barthii	30.21	2.00e-21	97.80
IUUC-Ogu-078206	Oryza glumaepatula	30.21	3.00e-21	97.10
IUUC-Oin-079439	Oryza indica	30.21	2.00e-21	97.40
IUUC-Olo-080886	Oryza longistaminata	30.21	2.00e-21	97.40
IUUC-Ome-081695	Oryza meridionalis	29.86	7.00e-21	95.90
IUUC-Oni-082350	Oryza nivara	30.21	2.00e-21	97.40
IUUC-Opu-083900	Oryza punctata	29.86	3.00e-21	97.10
IUUC-Oru-085212	Oryza rufipogon	30.21	2.00e-21	97.40
IUUC-Ola-086521	Oryzias latipes	80.79	0.00e+00	768.00
IUUC-Oga-088153	Otolemur garnettii	77.65	0.00e+00	796.00
IUUC-Oar-090184	Ovis aries	77.69	0.00e+00	799.00
IUUC-Ptr-090505	Pan troglodytes	74.00	0.00e+00	773.00
IUUC-Pan-092260	Papio anubis	78.78	0.00e+00	811.00
IUUC-Pma-094311	Petromyzon marinus	71.94	0.00e+00	684.00
IUUC-Pfo-096566	Poecilia formosa	74.90	0.00e+00	785.00
IUUC-Pva-103021	Pteropus vampyrus	78.59	0.00e+00	807.00
IUUC-Rno-105309	Rattus norvegicus	77.36	0.00e+00	805.00
IUUC-Sha-107099	Sarcophilus harrisii	76.32	0.00e+00	796.00
IUUC-Sit-110182	Setaria italica	31.47	2.00e-22	100.00
IUUC-Sbi-114267	Sorghum bicolor	31.12	1.00e-22	101.00
IUUC-Tgu-116912	Taeniopygia guttata	84.87	0.00e+00	888.00
IUUC-Tru-118449	Takifugu rubripes	80.31	0.00e+00	755.00
IUUC-Tca-121461	Theobroma cacao	29.47	1.00e-20	94.70
IUUC-Tae-125706	Triticum aestivum	31.21	2.00e-22	100.00
IUUC-Tur-126322	Triticum urartu	30.85	5.00e-22	99.00
IUUC-Tbe-128144	Tupaia belangeri	75.60	0.00e+00	694.00
IUUC-Xma-133902	Xiphophorus maculatus	74.46	0.00e+00	778.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence