iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000012601.3	ENSMMUT00000044638.2	ENSMMUP00000037662.2
ENSMMUG00000012601.3	ENSMMUT00000071964.1	ENSMMUP00000044209.1
ENSMMUG00000012601.3	ENSMMUT00000054056.1	ENSMMUP00000058737.1
ENSMMUG00000012601.3	ENSMMUT00000017664.3	ENSMMUP00000016541.3
ENSMMUG00000012601.3	ENSMMUT00000017662.3	ENSMMUP00000016539.3
ENSMMUG00000012601.3	ENSMMUT00000078310.1	ENSMMUP00000057093.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/NZF	6.20e-11	42.7	195	221
ULD/UDP/UBQ/UBQ_Other	1.60e-06	29.0	60	122

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 3    aqWaCsaCTflNePeavkCemCsrpRg 29
            +W+C+ CTf+N+P +++CemC+r R+
   Q: 195  VGWQCPGCTFINKPTRPGCEMCCRARP 221
           68************************8 PP

ULD/UDP/UBQ/UBQ_Other

   S: 4    tvksldgseltlk..vnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglkdg 64
            v++++  + t++  v p++tVa LK++++   g+pp  q++++ G+ L +d  tL ++g++++
   Q: 60   SVEDAQMHTVTIWltVRPDMTVASLKDMVFLDYGFPPVLQQWVI-GQRLaRDQETLHSHGVRQN 122
           5666665577777889****************************.55555**********9875 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MDEKTKKAEE MALSLTRAVA GGDEQVAMKC AIWLAEQRVP LSVQLKPEVS PTQDIRLWVS 60
VEDAQMHTVT IWLTVRPDMT VASLKDMVFL DYGFPPVLQQ WVIGQRLARD QETLHSHGVR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCGCTGGAA CCCCGCCCTC GGCGTCCGCC GCCGCCGGGT GGCCGGGCAT TGGAGGTCCC 60
GGATGAGGCG ACAATTTTTC CGGCCCCCCT CCCAGTCCCG CCCCACTTCC GGGGCCGCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR002867--IBR_dom
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR027370--Znf-RING_LisH
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50053--UBIQUITIN_2
PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF01485--IBR
PF13445--zf-RING_UBOX

SMART

SM00184--RING
SM00547--ZnF_RBZ

Gene Ontology

GO:0071797--C:LUBAC complex
GO:0043130--F:ubiquitin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0060546--P:negative regulation of necroptotic process
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0042346--P:positive regulation of NF-kappaB import into nucleus
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0097039--P:protein linear polyubiquitination
GO:0050852--P:T cell receptor signaling pathway

KEGG

mcc:714692

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001540	Ailuropoda melanoleuca	92.16	0.00e+00	857.00
IUUC-Apl-003627	Anas platyrhynchos	61.54	7.00e-19	84.70
IUUC-Aca-004507	Anolis carolinensis	63.88	1.00e-152	532.00
IUUC-Ame-011008	Astyanax mexicanus	52.76	5.00e-143	501.00
IUUC-Bta-013247	Bos taurus	94.31	0.00e+00	904.00
IUUC-Cja-018880	Callithrix jacchus	97.84	0.00e+00	936.00
IUUC-Cfa-020477	Canis familiaris	94.31	0.00e+00	906.00
IUUC-Cpo-021558	Cavia porcellus	90.00	0.00e+00	854.00
IUUC-Csa-024129	Chlorocebus sabaeus	98.82	0.00e+00	900.00
IUUC-Cin-025630	Ciona intestinalis	39.67	9.00e-81	294.00
IUUC-Csv-026069	Ciona savignyi	51.20	7.00e-72	263.00
IUUC-Dre-027591	Danio rerio	52.92	2.00e-141	496.00
IUUC-Dno-029015	Dasypus novemcinctus	91.96	0.00e+00	867.00
IUUC-Dor-030313	Dipodomys ordii	81.67	0.00e+00	738.00
IUUC-Ete-032908	Echinops telfairi	81.00	0.00e+00	758.00
IUUC-Eca-034295	Equus caballus	77.14	0.00e+00	723.00
IUUC-Eeu-034454	Erinaceus europaeus	86.78	8.00e-117	414.00
IUUC-Fca-036380	Felis catus	94.90	0.00e+00	909.00
IUUC-Fal-037440	Ficedula albicollis	56.90	3.00e-15	72.80
IUUC-Gmo-038561	Gadus morhua	53.39	2.00e-118	419.00
IUUC-Gga-040198	Gallus gallus	38.58	1.00e-28	120.00
IUUC-Gac-041319	Gasterosteus aculeatus	52.34	1.00e-136	479.00
IUUC-Ggo-044456	Gorilla gorilla	68.27	6.00e-158	550.00
IUUC-Hsa-045738	Homo sapiens	99.61	0.00e+00	902.00
IUUC-Itr-049042	Ictidomys tridecemlineatus	92.55	0.00e+00	862.00
IUUC-Lch-050269	Latimeria chalumnae	44.28	3.00e-114	405.00
IUUC-Loc-052776	Lepisosteus oculatus	48.82	3.00e-133	469.00
IUUC-Laf-054269	Loxodonta africana	91.37	0.00e+00	878.00
IUUC-Mga-059615	Meleagris gallopavo	54.69	1.00e-17	80.50
IUUC-Mmr-061562	Microcebus murinus	93.38	0.00e+00	775.00
IUUC-Mdo-062263	Monodelphis domestica	77.91	0.00e+00	748.00
IUUC-Mmu-064325	Mus musculus	91.18	0.00e+00	847.00
IUUC-Mpu-066385	Mustela putorius furo	94.31	0.00e+00	902.00
IUUC-Mlu-067000	Myotis lucifugus	90.98	0.00e+00	857.00
IUUC-Nle-069812	Nomascus leucogenys	98.82	0.00e+00	909.00
IUUC-Opr-070575	Ochotona princeps	93.14	6.00e-106	377.00
IUUC-Ont-072405	Oreochromis niloticus	52.10	1.00e-137	483.00
IUUC-Ocu-074358	Oryctolagus cuniculus	80.80	0.00e+00	769.00
IUUC-Ola-086403	Oryzias latipes	53.01	1.00e-139	489.00
IUUC-Oga-087986	Otolemur garnettii	93.33	0.00e+00	853.00
IUUC-Oar-089600	Ovis aries	92.16	0.00e+00	898.00
IUUC-Ptr-091224	Pan troglodytes	99.41	0.00e+00	900.00
IUUC-Pan-092739	Papio anubis	99.80	0.00e+00	917.00
IUUC-Pma-094407	Petromyzon marinus	43.84	3.00e-113	402.00
IUUC-Pfo-097161	Poecilia formosa	52.89	3.00e-133	468.00
IUUC-Pab-098627	Pongo abelii	99.41	0.00e+00	894.00
IUUC-Pca-100641	Procavia capensis	91.82	0.00e+00	818.00
IUUC-Pva-102670	Pteropus vampyrus	91.57	0.00e+00	862.00
IUUC-Rno-105504	Rattus norvegicus	90.98	0.00e+00	844.00
IUUC-Sha-107342	Sarcophilus harrisii	77.91	0.00e+00	767.00
IUUC-Sar-113425	Sorex araneus	88.13	2.00e-113	402.00
IUUC-Ssc-115904	Sus scrofa	93.06	5.00e-89	319.00
IUUC-Tru-118096	Takifugu rubripes	51.54	6.00e-138	484.00
IUUC-Tni-119873	Tetraodon nigroviridis	49.71	1.00e-137	483.00
IUUC-Tbe-127578	Tupaia belangeri	90.54	0.00e+00	692.00
IUUC-Ttr-129107	Tursiops truncatus	94.12	0.00e+00	856.00
IUUC-Vpa-130353	Vicugna pacos	95.14	3.00e-124	437.00
IUUC-Xtr-132168	Xenopus tropicalis	42.41	2.00e-93	336.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence