iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-073578

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPN01039731

Gene Name

TRAF6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000011769.2	ENSOANT00000018660.2	ENSOANP00000018657.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	3.00e-07	30.6	66	127

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrli 65
           + + CpI l   r+ v +p+G+ + +++I k +++ g++cPv+++ l e++l P ++ +r i
   Q: 66   SKYECPICLMALREAVQTPCGHRFCKACIVKSIRDAGHKCPVDNEILLENQLFPDNFAKREI 127
           5689*****************************999999*****************999977 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MSLLNCENSC GASQSEGDCC AAMASACSAG AKDDSVSSSV NTGNLHNSFM AETQGYDVEF 60
DPPLESKYEC PICLMALREA VQTPCGHRFC KACIVKSIRD AGHKCPVDNE ILLENQLFPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTGCTTGG CCAATCAGTT ACTATGAGTC TGCTTAACTG TGAAAACAGC TGTGGAGCCA 60
GCCAGTCCGA GGGTGACTGT TGCGCTGCCA TGGCCAGTGC CTGCAGCGCC GGAGCCAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027139--TRAF6
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045453--P:bone resorption
GO:0048468--P:cell development
GO:0071222--P:cellular response to lipopolysaccharide
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0070498--P:interleukin-1-mediated signaling pathway
GO:0043011--P:myeloid dendritic cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001843--P:neural tube closure
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0001503--P:ossification
GO:0030316--P:osteoclast differentiation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084--P:positive regulation of interleukin-12 biosynthetic process
GO:0032743--P:positive regulation of interleukin-2 production
GO:0045410--P:positive regulation of interleukin-6 biosynthetic process
GO:0043507--P:positive regulation of JUN kinase activity
GO:0031666--P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045672--P:positive regulation of osteoclast differentiation
GO:0002726--P:positive regulation of T cell cytokine production
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051023--P:regulation of immunoglobulin secretion
GO:0050852--P:T cell receptor signaling pathway
GO:0042088--P:T-helper 1 type immune response

KEGG

oaa:100077058

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001262	Ailuropoda melanoleuca	83.27	0.00e+00	887.00
IUUC-Apl-004062	Anas platyrhynchos	76.46	0.00e+00	854.00
IUUC-Aca-004636	Anolis carolinensis	72.63	0.00e+00	794.00
IUUC-Ame-011682	Astyanax mexicanus	55.34	5.00e-165	573.00
IUUC-Bta-012692	Bos taurus	81.65	0.00e+00	897.00
IUUC-Bdi-014026	Brachypodium distachyon	31.93	6.00e-08	50.40
IUUC-Cja-019426	Callithrix jacchus	81.25	0.00e+00	884.00
IUUC-Cfa-020948	Canis familiaris	80.82	0.00e+00	799.00
IUUC-Cpo-021378	Cavia porcellus	82.78	0.00e+00	905.00
IUUC-Csa-024045	Chlorocebus sabaeus	81.25	0.00e+00	896.00
IUUC-Cho-024973	Choloepus hoffmanni	63.31	3.00e-85	308.00
IUUC-Csv-026300	Ciona savignyi	43.18	5.00e-47	180.00
IUUC-Dre-027557	Danio rerio	58.51	2.00e-177	614.00
IUUC-Dno-030032	Dasypus novemcinctus	79.64	5.00e-138	483.00
IUUC-Dor-030790	Dipodomys ordii	80.51	0.00e+00	877.00
IUUC-Dse-031478	Dothistroma septosporum	24.77	2.00e-11	63.90
IUUC-Dme-031921	Drosophila melanogaster	27.65	6.00e-43	167.00
IUUC-Ete-032952	Echinops telfairi	78.30	2.00e-156	545.00
IUUC-Eca-033924	Equus caballus	78.75	0.00e+00	811.00
IUUC-Eeu-034734	Erinaceus europaeus	62.67	0.00e+00	644.00
IUUC-Fca-036222	Felis catus	79.63	0.00e+00	820.00
IUUC-Fal-036834	Ficedula albicollis	78.42	0.00e+00	790.00
IUUC-Fox-037935	Fusarium oxysporum	29.25	5.00e-22	98.60
IUUC-Gmo-039061	Gadus morhua	61.60	1.00e-84	306.00
IUUC-Ggr-040084	Gaeumannomyces graminis	27.45	4.00e-16	79.00
IUUC-Gga-040599	Gallus gallus	76.75	0.00e+00	857.00
IUUC-Gac-041977	Gasterosteus aculeatus	56.61	1.00e-170	592.00
IUUC-Gma-042951	Glycine max	28.81	5.00e-10	58.20
IUUC-Ggo-044508	Gorilla gorilla	77.66	0.00e+00	830.00
IUUC-Hsa-046349	Homo sapiens	81.62	0.00e+00	900.00
IUUC-Itr-047966	Ictidomys tridecemlineatus	81.80	0.00e+00	892.00
IUUC-Lch-049821	Latimeria chalumnae	68.87	0.00e+00	760.00
IUUC-Loc-051995	Lepisosteus oculatus	62.96	0.00e+00	651.00
IUUC-Laf-054115	Loxodonta africana	80.88	0.00e+00	894.00
IUUC-Mcc-055298	Macaca mulatta	80.88	0.00e+00	890.00
IUUC-Mor-057263	Magnaporthe oryzae	31.94	2.00e-19	90.10
IUUC-Mpo-057517	Magnaporthe poae	29.41	3.00e-18	86.30
IUUC-Mga-059340	Meleagris gallopavo	77.68	0.00e+00	861.00
IUUC-Mvi-060553	Microbotryum violaceum	28.57	6.00e-15	74.70
IUUC-Mmr-061063	Microcebus murinus	82.35	0.00e+00	895.00
IUUC-Mdo-062075	Monodelphis domestica	81.47	0.00e+00	899.00
IUUC-Mmu-063780	Mus musculus	79.23	0.00e+00	841.00
IUUC-Mpu-065748	Mustela putorius furo	82.35	0.00e+00	896.00
IUUC-Mlu-067888	Myotis lucifugus	81.62	0.00e+00	884.00
IUUC-Nle-069234	Nomascus leucogenys	81.80	0.00e+00	903.00
IUUC-Opr-070393	Ochotona princeps	90.61	7.00e-116	410.00
IUUC-Ont-072459	Oreochromis niloticus	57.53	1.00e-176	612.00
IUUC-Ocu-074201	Oryctolagus cuniculus	83.27	0.00e+00	906.00
IUUC-Ola-087319	Oryzias latipes	61.00	8.00e-87	313.00
IUUC-Olu-087748	Ostreococcus lucimarinus	23.36	1.00e-10	60.10
IUUC-Oga-087936	Otolemur garnettii	80.88	0.00e+00	885.00
IUUC-Oar-089379	Ovis aries	81.47	0.00e+00	905.00
IUUC-Ptr-090758	Pan troglodytes	81.43	0.00e+00	895.00
IUUC-Pan-092590	Papio anubis	81.07	0.00e+00	892.00
IUUC-Psi-093948	Pelodiscus sinensis	76.42	0.00e+00	850.00
IUUC-Pma-094434	Petromyzon marinus	45.09	7.00e-126	443.00
IUUC-Pfo-096912	Poecilia formosa	56.77	3.00e-173	600.00
IUUC-Pab-097651	Pongo abelii	81.43	0.00e+00	898.00
IUUC-Pop-099898	Populus trichocarpa	30.56	4.00e-09	55.50
IUUC-Pca-100958	Procavia capensis	77.72	0.00e+00	645.00
IUUC-Ppe-101547	Prunus persica	29.06	2.00e-10	60.50
IUUC-Pva-103247	Pteropus vampyrus	79.37	2.00e-112	398.00
IUUC-Rno-104994	Rattus norvegicus	78.12	0.00e+00	857.00
IUUC-Sha-106494	Sarcophilus harrisii	82.35	0.00e+00	904.00
IUUC-Stu-112694	Solanum tuberosum	37.84	2.00e-08	52.00
IUUC-Sar-113375	Sorex araneus	81.83	0.00e+00	880.00
IUUC-Sre-115218	Sporisorium reilianum	26.91	3.00e-16	79.70
IUUC-Ssc-115417	Sus scrofa	82.20	0.00e+00	905.00
IUUC-Tgu-117232	Taeniopygia guttata	76.57	0.00e+00	839.00
IUUC-Tru-118321	Takifugu rubripes	57.42	6.00e-173	599.00
IUUC-Tni-120475	Tetraodon nigroviridis	57.49	1.00e-167	582.00
IUUC-Tbe-127719	Tupaia belangeri	71.79	0.00e+00	749.00
IUUC-Ttr-129264	Tursiops truncatus	77.87	5.00e-109	387.00
IUUC-Uma-129620	Ustilago maydis	26.98	2.00e-17	84.00
IUUC-Vpa-130244	Vicugna pacos	79.05	2.00e-114	405.00
IUUC-Vvi-131070	Vitis vinifera	26.18	4.00e-10	58.50
IUUC-Xtr-131948	Xenopus tropicalis	67.08	0.00e+00	745.00
IUUC-Xma-133132	Xiphophorus maculatus	57.01	2.00e-174	605.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence