• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063613
Ensembl Protein ID ENSMUSP00000045890.7
UniProt Accession Q3V3E1; Q3TED7; UBS3A_MOUSE
Genbank Protein ID BAE20600.1; BAE41311.1; CAX15943.1; CAX15943.1; CAX15943.1
Protein Name Ubiquitin-associated and SH3 domain-containing protein A; Suppressor of T-cell receptor signaling 2; T-cell ubiquitin ligand 1
Genbank Nucleotide ID AK041690; AK169696; CU024900; AC154652; AC167247
Gene Name Ubash3a; Sts2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000042345.14 ENSMUST00000048656.13 ENSMUSP00000045890.7
ENSMUSG00000042345.14 ENSMUST00000144772.7 ENSMUSP00000119279.1
ENSMUSG00000042345.14 ENSMUST00000173776.1 ENSMUSP00000134557.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 20670933
Classification
Family E-value Score Start End
UBD/SH3 5.20e-16 59.5 241 302
UBD/Alpha-Helix/UBA 1.50e-07 32.4 23 60
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlvi..ekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++++l++y++qn deL l +Gd ++v   ++ee +egW  g ++ +g+rG++Pen++e+++
   Q: 241  QTLKALFQYKPQNADELMLSAGDYIFVDptQQEEASEGWAIGISHRTGCRGFLPENYTERAN 302
           5789***********************9999****************************997 PP
   

   UBD/Alpha-Helix/UBA
   S: 5    dkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
           ++l+ l +MGF++++al+aL+a+  +++eaA+++L+ +
   Q: 23   SLLDPLLAMGFPTHTALKALAATgRKTAEAAADWLHGH 60
           78999******************************865 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain (By similarity). Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation.
 Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain (By similarity). Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation.
Protein Sequence
(Fasta)
MAAGETQLYA KVSNKLKGRS TPSLLDPLLA MGFPTHTALK ALAATGRKTA EAAADWLHGH 60
CNDPSLDDPI PQEYALFLCP TGPLLEKLQE FWRESRRQCA KNRAHEVFPH VTLCDFFTCE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063613|UBD,UBA;UBD,SH3|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGATCCCAGT GATGAACTTC GGCCCAGACC GCACTGTGGA AGCCGGTGGG TTTGGAAGCC 60
ACTGCTGTGG GTCGGCAAGG AGAATTCAAG CCCCGAACAT TGTGCAAACA GGATATTCAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063613|UBD,UBA;UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR009097--cNuc_Pdiesterase
IPR013078--His_Pase_superF_clade-1
IPR029033--His_PPase_superfam
IPR001452--SH3_domain
IPR015940--UBA
IPR009060--UBA-like
PROSITE

PS50002--SH3
PS50030--UBA
Pfam

PF00300--His_Phos_1
PF14604--SH3_9
PF00627--UBA
SMART

SM00326--SH3
Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0050860--P:negative regulation of T cell receptor signaling pathway
GO:0001817--P:regulation of cytokine production
KEGG mmu:328795
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001941 Ailuropoda melanoleuca 84.38 0.00e+00 1104.00
IUUC-Atr-003098 Amborella trichopoda 31.58 2.00e-06 46.60
IUUC-Apl-003555 Anas platyrhynchos 66.51 0.00e+00 882.00
IUUC-Aca-004356 Anolis carolinensis 63.52 0.00e+00 680.00
IUUC-Aly-006369 Arabidopsis lyrata 29.29 4.00e-04 38.50
IUUC-Ath-006661 Arabidopsis thaliana 28.57 4.00e-04 38.90
IUUC-Bta-012798 Bos taurus 81.12 0.00e+00 1051.00
IUUC-Bol-015778 Brassica oleracea 32.00 1.00e-04 40.40
IUUC-Bra-017339 Brassica rapa 33.00 1.00e-04 40.40
IUUC-Cja-018791 Callithrix jacchus 70.84 0.00e+00 894.00
IUUC-Cfa-020366 Canis familiaris 84.06 0.00e+00 1090.00
IUUC-Cpo-022474 Cavia porcellus 80.06 0.00e+00 1009.00
IUUC-Csa-023131 Chlorocebus sabaeus 83.97 0.00e+00 1090.00
IUUC-Cho-024803 Choloepus hoffmanni 65.88 4.00e-114 405.00
IUUC-Dno-028890 Dasypus novemcinctus 71.04 0.00e+00 923.00
IUUC-Dor-031140 Dipodomys ordii 82.32 2.00e-159 555.00
IUUC-Dse-031474 Dothistroma septosporum 26.58 2.00e-07 49.70
IUUC-Ete-032656 Echinops telfairi 74.34 0.00e+00 641.00
IUUC-Eca-033634 Equus caballus 84.62 0.00e+00 1087.00
IUUC-Fca-035845 Felis catus 81.96 0.00e+00 1071.00
IUUC-Fal-037247 Ficedula albicollis 65.65 0.00e+00 851.00
IUUC-Gga-040276 Gallus gallus 66.35 0.00e+00 823.00
IUUC-Gma-044050 Glycine max 26.51 3.00e-06 45.80
IUUC-Ggo-045383 Gorilla gorilla 78.25 0.00e+00 1065.00
IUUC-Hsa-046684 Homo sapiens 78.40 0.00e+00 1032.00
IUUC-Itr-048202 Ictidomys tridecemlineatus 79.36 0.00e+00 1040.00
IUUC-Lch-049841 Latimeria chalumnae 58.47 0.00e+00 684.00
IUUC-Lma-053306 Leptosphaeria maculans 27.40 7.00e-06 44.70
IUUC-Laf-053867 Loxodonta africana 79.55 0.00e+00 1000.00
IUUC-Mcc-055524 Macaca mulatta 80.25 0.00e+00 1068.00
IUUC-Meu-056469 Macropus eugenii 63.21 5.00e-157 548.00
IUUC-Mtr-057682 Medicago truncatula 30.48 1.00e-04 40.40
IUUC-Mga-059265 Meleagris gallopavo 65.38 0.00e+00 820.00
IUUC-Mmr-061107 Microcebus murinus 80.48 0.00e+00 1028.00
IUUC-Mdo-062508 Monodelphis domestica 72.62 0.00e+00 946.00
IUUC-Mac-064775 Musa acuminata 36.36 8.00e-06 43.90
IUUC-Mpu-066673 Mustela putorius furo 81.86 0.00e+00 1034.00
IUUC-Mlu-068057 Myotis lucifugus 76.50 0.00e+00 1032.00
IUUC-Nle-070135 Nomascus leucogenys 77.48 0.00e+00 993.00
IUUC-Oan-073094 Ornithorhynchus anatinus 70.32 0.00e+00 804.00
IUUC-Ocu-074819 Oryctolagus cuniculus 79.55 0.00e+00 1011.00
IUUC-Oba-075491 Oryza barthii 29.03 5.00e-05 41.60
IUUC-Obr-076070 Oryza brachyantha 27.27 3.00e-03 35.40
IUUC-Ogl-077162 Oryza glaberrima 29.03 5.00e-05 41.60
IUUC-Oin-080005 Oryza indica 29.03 4.00e-05 41.60
IUUC-Oni-082745 Oryza nivara 29.03 4.00e-05 42.00
IUUC-Opu-084066 Oryza punctata 26.98 8.00e-04 37.40
IUUC-Oru-084674 Oryza rufipogon 29.03 5.00e-05 41.60
IUUC-Osa-085577 Oryza sativa 29.03 4.00e-05 41.60
IUUC-Oga-088835 Otolemur garnettii 82.05 0.00e+00 1067.00
IUUC-Oar-089742 Ovis aries 77.88 0.00e+00 1008.00
IUUC-Ptr-091345 Pan troglodytes 78.25 0.00e+00 1035.00
IUUC-Pan-092316 Papio anubis 78.97 0.00e+00 1067.00
IUUC-Pab-098009 Pongo abelii 77.24 0.00e+00 990.00
IUUC-Pop-099403 Populus trichocarpa 28.70 1.00e-04 40.40
IUUC-Pca-100920 Procavia capensis 64.20 3.00e-120 426.00
IUUC-Ppe-101806 Prunus persica 27.18 3.00e-05 42.70
IUUC-Pva-102692 Pteropus vampyrus 75.75 0.00e+00 654.00
IUUC-Pyt-104727 Pyrenophora triticirepentis 26.39 2.00e-05 43.10
IUUC-Rno-106073 Rattus norvegicus 93.91 0.00e+00 1184.00
IUUC-Sce-106219 Saccharomyces cerevisiae 28.57 2.00e-03 37.00
IUUC-Sha-106789 Sarcophilus harrisii 73.59 0.00e+00 970.00
IUUC-Smo-109333 Selaginella moellendorffii 34.38 3.00e-06 45.80
IUUC-Sly-111172 Solanum lycopersicum 29.70 8.00e-04 37.40
IUUC-Stu-112768 Solanum tuberosum 30.77 2.00e-04 39.30
IUUC-Ssc-115747 Sus scrofa 82.05 0.00e+00 1051.00
IUUC-Tgu-116653 Taeniopygia guttata 65.92 0.00e+00 838.00
IUUC-Tsy-119559 Tarsius syrichta 69.51 0.00e+00 814.00
IUUC-Tca-121384 Theobroma cacao 29.91 3.00e-04 39.30
IUUC-Tbe-127815 Tupaia belangeri 68.45 0.00e+00 885.00
IUUC-Ttr-129181 Tursiops truncatus 73.18 0.00e+00 640.00
IUUC-Vda-129751 Verticillium dahliae 25.60 2.00e-08 53.50
IUUC-Vpa-130759 Vicugna pacos 48.40 1.00e-95 343.00
IUUC-Vvi-131385 Vitis vinifera 27.59 7.00e-03 34.70
IUUC-Yli-134663 Yarrowia lipolytica 29.60 6.00e-05 42.40
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved