iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-013171

Ensembl Protein ID

ENSBTAP00000019573.4

UniProt Accession

O02741; Q3T0N6; ISG15_BOVIN

Genbank Protein ID

AAB57687.1; AAD56716.1; AAI02319.1

Protein Name

Ubiquitin-like protein ISG15; Interferon-stimulated gene product 17; Ubiquitin cross-reactive protein

Genbank Nucleotide ID

U96014; AF069133; BC102318

Gene Name

ISG15; G1P2; ISG17; UCRP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000014707.4	ENSBTAT00000019573.4	ENSBTAP00000019573.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_Other	4.00e-26	90.8	79	153

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_Other

   S: 1    vqvtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllekksg 75
           +++ v++++g++ +++v    tVaeLK+++ +k+ ++++q  L ++G++++d ++L +ygl+ g+t+++ ++ +g
   Q: 79   ISILVRNDKGRSSPYEVQLKQTVAELKQQVCQKERVQADQFWLSFEGRPMDDEHPLEEYGLMKGCTVFMNLRLRG 153
           5799*****************************************************************999876 PP

Organism

Bos taurus

Functional Description
(View)

Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Exhibits antiviral activity towards both DNA and RNA viruses. The secreted form of ISG15 can: induce natural killer cell proliferation, augment lymphokine-activated-killer (LAK) activity, induce dendritic cell maturation, act as a chemotactic factor for neutrophils and act as a IFN-gamma-inducing cytokine playing an essential role in antimycobacterial immunity (By similarity). In response to IFN-tau secreted by the conceptus, may ligate to and regulate proteins involved in the release of prostaglandin F2-alpha (PGF), and thus prevent lysis of the corpus luteum and maintain the pregnancy.

Protein Sequence
(Fasta)

MGGDLTVKML GGQEILVPLR DSMTVSELKQ FIAQKINVPA FQQRLAHLDS REVLQEGVPL 60
VLQGLRAGST VLLVVQNCIS ILVRNDKGRS SPYEVQLKQT VAELKQQVCQ KERVQADQFW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCCGAGAG CAGAGAGGCA GCCGCAGCCA ACCAGTGTCT GCAGAGAGCC TGGCACCAGA 60
ACCCACGGCC ATGGTGAGTG GTGAGGCGGG TTTGACAGGT GGGGCTCTGT ATTCCCCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0051--Antiviral defense
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1015--Disulfide bond
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0677--Repeat
KW-0702--S-nitrosylation
KW-0964--Secreted
KW-0833--Ubl conjugation pathway

Interpro

IPR019956--Ubiquitin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF00240--ubiquitin

PRINTS

PR00348--UBIQUITIN

SMART

SM00213--UBQ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005576--C:extracellular region
GO:0031386--F:protein tag
GO:0042742--P:defense response to bacterium
GO:0051607--P:defense response to virus
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process
GO:0031397--P:negative regulation of protein ubiquitination
GO:0045071--P:negative regulation of viral genome replication
GO:0030501--P:positive regulation of bone mineralization
GO:0045648--P:positive regulation of erythrocyte differentiation
GO:0032649--P:regulation of interferon-gamma production
GO:0034340--P:response to type I interferon

KEGG

bta:281871

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001878	Ailuropoda melanoleuca	70.59	3.00e-55	207.00
IUUC-Cja-019835	Callithrix jacchus	66.88	2.00e-51	194.00
IUUC-Cfa-020065	Canis familiaris	70.97	6.00e-57	213.00
IUUC-Cpo-021861	Cavia porcellus	58.44	2.00e-42	164.00
IUUC-Csa-023867	Chlorocebus sabaeus	66.24	6.00e-45	172.00
IUUC-Dno-029882	Dasypus novemcinctus	66.03	2.00e-51	194.00
IUUC-Dor-030951	Dipodomys ordii	64.24	2.00e-45	174.00
IUUC-Eca-034085	Equus caballus	72.44	3.00e-56	210.00
IUUC-Fca-035436	Felis catus	69.43	2.00e-56	211.00
IUUC-Ggo-045637	Gorilla gorilla	65.61	3.00e-49	187.00
IUUC-Hsa-046999	Homo sapiens	65.61	8.00e-44	169.00
IUUC-Itr-048270	Ictidomys tridecemlineatus	66.67	5.00e-51	192.00
IUUC-Laf-053813	Loxodonta africana	63.87	6.00e-50	189.00
IUUC-Mcc-055557	Macaca mulatta	66.24	2.00e-49	188.00
IUUC-Mmr-060685	Microcebus murinus	65.61	9.00e-49	185.00
IUUC-Mdo-062517	Monodelphis domestica	47.37	1.00e-24	105.00
IUUC-Mmu-064385	Mus musculus	62.42	3.00e-43	167.00
IUUC-Mpu-066848	Mustela putorius furo	70.70	1.00e-57	215.00
IUUC-Ocu-074687	Oryctolagus cuniculus	63.46	5.00e-47	179.00
IUUC-Oga-089098	Otolemur garnettii	64.67	3.00e-47	180.00
IUUC-Oar-089908	Ovis aries	87.90	4.00e-77	280.00
IUUC-Ptr-090653	Pan troglodytes	65.61	4.00e-49	186.00
IUUC-Pan-092485	Papio anubis	66.88	4.00e-50	189.00
IUUC-Pab-098308	Pongo abelii	65.61	3.00e-49	187.00
IUUC-Rno-106108	Rattus norvegicus	63.69	5.00e-51	192.00
IUUC-Sha-107193	Sarcophilus harrisii	43.54	7.00e-25	106.00
IUUC-Ssc-115784	Sus scrofa	71.79	4.00e-56	210.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence