iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-064352

UUCD1 version

UUC-MuM-00820

Ensembl Protein ID

ENSMUSP00000128509.1

UniProt Accession

Q9CYB0; A6H6L2; Q8CEV0; Q923J0; Q925P1; Q99PQ0; TRI13_MOUSE

Genbank Protein ID

AAK56791.1; BAC25419.1; BAB30973.1; EDL36095.1; EDL36096.1; AAI38577.1; AAI45916.1; AAG53502.1; AAK51689.1

Protein Name

E3 ubiquitin-protein ligase TRIM13; Putative tumor suppressor RFP2; RING-type E3 ubiquitin transferase TRIM13; Ret finger protein 2; Tripartite motif-containing protein 13

Genbank Nucleotide ID

AY033605; AK013959; AK017850; CH466535; CH466535; BC138576; BC145915; AF220129; AF302839

Gene Name

Trim13; Rfp2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000035235.12	ENSMUST00000165015.7	ENSMUSP00000128509.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	5.10e-08	34.4	10	58

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw....pglknssskefrCPlCr 46
           C+iC++ f+d p+vlpC H f+++Cl+ +    +  +      f+CP+Cr
   Q: 10   CPICCSLFDD-PRVLPCSHNFCKKCLEGLlegnVRNSLWRPSPFKCPTCR 58
           ********99.**************96666666666666999999****8 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor.

Protein Sequence
(Fasta)

MELLEEDLTC PICCSLFDDP RVLPCSHNFC KKCLEGLLEG NVRNSLWRPS PFKCPTCRKE 60
TSATGVNSLQ VNYSLKGIVE KYNKIKISPK MPVCKGHLGQ PLNIFCVTDM QLICGICATR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCCCCACTC CTTTGTTTTT TGGCCTTTAT GGAAGGAGCT TCAGTTAAGA GATAGAGATC 60
ATCCTTTGCG TTTGGGCTAA CAGTGGAGTA CAGGCAGGAC TCGGGCAAAA CGGAAATCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00643--zf-B_box
PF13445--zf-RING_UBOX

SMART

SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0097038--C:perinuclear endoplasmic reticulum
GO:0004871--F:signal transducer activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0010942--P:positive regulation of cell death
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0016239--P:positive regulation of macroautophagy
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0010332--P:response to gamma radiation
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

mmu:66597

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002269	Ailuropoda melanoleuca	88.45	0.00e+00	703.00
IUUC-Apl-004168	Anas platyrhynchos	74.57	9.00e-179	619.00
IUUC-Aca-004395	Anolis carolinensis	66.04	4.00e-162	564.00
IUUC-Ame-011325	Astyanax mexicanus	46.44	1.00e-66	247.00
IUUC-Bta-012613	Bos taurus	89.19	0.00e+00	710.00
IUUC-Cja-018856	Callithrix jacchus	88.21	0.00e+00	739.00
IUUC-Cfa-021019	Canis familiaris	87.96	0.00e+00	697.00
IUUC-Cpo-021845	Cavia porcellus	88.70	0.00e+00	699.00
IUUC-Csa-023380	Chlorocebus sabaeus	88.21	0.00e+00	705.00
IUUC-Cho-024733	Choloepus hoffmanni	78.73	1.00e-84	306.00
IUUC-Dre-028675	Danio rerio	60.20	3.00e-109	388.00
IUUC-Dno-030018	Dasypus novemcinctus	87.01	0.00e+00	694.00
IUUC-Dor-030599	Dipodomys ordii	86.14	8.00e-120	422.00
IUUC-Dse-031522	Dothistroma septosporum	32.89	7.00e-06	45.10
IUUC-Ete-033134	Echinops telfairi	85.05	0.00e+00	699.00
IUUC-Eca-033931	Equus caballus	89.68	0.00e+00	701.00
IUUC-Eeu-034903	Erinaceus europaeus	87.47	0.00e+00	696.00
IUUC-Fca-035642	Felis catus	89.19	0.00e+00	703.00
IUUC-Fal-037108	Ficedula albicollis	75.25	2.00e-180	624.00
IUUC-Gga-040903	Gallus gallus	72.75	9.00e-174	602.00
IUUC-Ggo-044635	Gorilla gorilla	88.94	0.00e+00	710.00
IUUC-Hsa-046345	Homo sapiens	88.94	0.00e+00	710.00
IUUC-Itr-048220	Ictidomys tridecemlineatus	88.05	0.00e+00	684.00
IUUC-Lch-050599	Latimeria chalumnae	59.70	5.00e-135	474.00
IUUC-Loc-052378	Lepisosteus oculatus	64.26	5.00e-119	420.00
IUUC-Laf-053332	Loxodonta africana	87.99	0.00e+00	697.00
IUUC-Mcc-054705	Macaca mulatta	87.71	0.00e+00	703.00
IUUC-Meu-056825	Macropus eugenii	81.37	0.00e+00	674.00
IUUC-Mga-059528	Meleagris gallopavo	72.79	6.00e-177	613.00
IUUC-Mmr-060688	Microcebus murinus	89.68	0.00e+00	708.00
IUUC-Mdo-061882	Monodelphis domestica	80.15	0.00e+00	675.00
IUUC-Mpu-066712	Mustela putorius furo	89.18	0.00e+00	652.00
IUUC-Mlu-068093	Myotis lucifugus	86.73	0.00e+00	689.00
IUUC-Nle-069310	Nomascus leucogenys	88.94	0.00e+00	707.00
IUUC-Ont-071759	Oreochromis niloticus	58.10	4.00e-110	391.00
IUUC-Oan-073673	Ornithorhynchus anatinus	77.94	0.00e+00	652.00
IUUC-Ocu-074192	Oryctolagus cuniculus	89.68	0.00e+00	715.00
IUUC-Ola-087424	Oryzias latipes	58.10	7.00e-110	390.00
IUUC-Oga-088808	Otolemur garnettii	88.70	0.00e+00	712.00
IUUC-Oar-089553	Ovis aries	89.19	0.00e+00	708.00
IUUC-Ptr-090518	Pan troglodytes	88.70	0.00e+00	706.00
IUUC-Pan-092781	Papio anubis	87.47	0.00e+00	701.00
IUUC-Psi-093914	Pelodiscus sinensis	73.72	1.00e-175	608.00
IUUC-Pfo-096346	Poecilia formosa	58.73	1.00e-110	392.00
IUUC-Pca-100914	Procavia capensis	85.54	0.00e+00	706.00
IUUC-Pva-102728	Pteropus vampyrus	88.70	0.00e+00	697.00
IUUC-Rno-105922	Rattus norvegicus	93.37	0.00e+00	716.00
IUUC-Sha-107124	Sarcophilus harrisii	80.64	0.00e+00	683.00
IUUC-Sar-113607	Sorex araneus	85.75	0.00e+00	675.00
IUUC-Ssc-116355	Sus scrofa	90.42	0.00e+00	715.00
IUUC-Tgu-116476	Taeniopygia guttata	75.00	6.00e-180	623.00
IUUC-Tru-118737	Takifugu rubripes	59.03	3.00e-111	395.00
IUUC-Tsy-118908	Tarsius syrichta	88.70	0.00e+00	715.00
IUUC-Tbe-127258	Tupaia belangeri	90.66	0.00e+00	715.00
IUUC-Vpa-130138	Vicugna pacos	88.94	0.00e+00	706.00
IUUC-Xtr-132100	Xenopus tropicalis	59.80	1.00e-135	476.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence