iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gga-040353

Ensembl Protein ID

ENSGALP00000018834.3

UniProt Accession

F1NWU0; F1NWU0_CHICK

Genbank Protein ID

ENSGALP00000018834

Protein Name

E3 ubiquitin-protein ligase parkin

Genbank Nucleotide ID

AADN04000070

Gene Name

PARK2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000011562.5	ENSGALT00000018857.4	ENSGALP00000018834.3

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UBQ/UBQ_PIM	UBQ_PIM	20064468

Classification

Family	E-value	Score	Start	End
ULD/UDP/UBQ/UBQ_PIM	1.00e-21	77.0	1	75

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkksk 75
           m ++v++++++ f++e+  d ++ +lKe++a+++gvp++q+++I+aG++L++d tL+++++ ++s+vh+v++ +k
   Q: 1    MIVFVRFNSSHGFPVELGLDASILQLKEAVAQRQGVPADQLRVIFAGRELSNDLTLQNCDLVQQSIVHIVQNLQK 75
           89*****99999**********************************************************99876 PP

Organism

Gallus gallus

Functional Description
(View)

Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

Protein Sequence
(Fasta)

MIVFVRFNSS HGFPVELGLD ASILQLKEAV AQRQGVPADQ LRVIFAGREL SNDLTLQNCD 60
LVQQSIVHIV QNLQKNSDKD ETEDNHAGGI LKTLERVPES LTRIDLSSSI LPSLSAGLAV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGATAGGTG AGTGAGCGCG CACCCCTGCC GAGAGCCCGG ATGCTGGTCC GCCCTTTCCT 60
GGCCGCATCG CTGCCGCTGC GGCAGGTGTC GGCTCCATGG GGACGCTGTG TGCTGTCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR003977--Parkin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF01485--IBR
PF00240--ubiquitin

PRINTS

PR01475--PARKIN

SMART

SM00647--IBR
SM00213--UBQ

Gene Ontology

GO:0016235--C:aggresome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005794--C:Golgi apparatus
GO:0071797--C:LUBAC complex
GO:0005739--C:mitochondrion
GO:0099073--C:mitochondrion-derived vesicle
GO:0043005--C:neuron projection
GO:0005634--C:nucleus
GO:1990452--C:Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0048471--C:perinuclear region of cytoplasm
GO:0098793--C:presynapse
GO:0043234--C:protein complex
GO:0000151--C:ubiquitin ligase complex
GO:0046872--F:metal ion binding
GO:0000976--F:transcription regulatory region sequence-specific DNA binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008344--P:adult locomotory behavior
GO:0070842--P:aggresome assembly
GO:0097237--P:cellular response to toxic substance
GO:0042417--P:dopamine metabolic process
GO:0051583--P:dopamine uptake involved in synaptic transmission
GO:0010994--P:free ubiquitin chain polymerization
GO:0007612--P:learning
GO:0000423--P:macromitophagy
GO:0099074--P:mitochondrion to lysosome transport
GO:0044828--P:negative regulation by host of viral genome replication
GO:0032232--P:negative regulation of actin filament bundle assembly
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:1903382--P:negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903542--P:negative regulation of exosomal secretion
GO:0033132--P:negative regulation of glucokinase activity
GO:0046676--P:negative regulation of insulin secretion
GO:1905366--P:negative regulation of intralumenal vesicle formation
GO:1902254--P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1903377--P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1902283--P:negative regulation of primary amine oxidase activity
GO:0001933--P:negative regulation of protein phosphorylation
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0090201--P:negative regulation of release of cytochrome c from mitochondria
GO:1904049--P:negative regulation of spontaneous neurotransmitter secretion
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0042415--P:norepinephrine metabolic process
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:0043388--P:positive regulation of DNA binding
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0010636--P:positive regulation of mitochondrial fusion
GO:0051582--P:positive regulation of neurotransmitter uptake
GO:1903378--P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032092--P:positive regulation of protein binding
GO:1902530--P:positive regulation of protein linear polyubiquitination
GO:1905477--P:positive regulation of protein localization to membrane
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:1903265--P:positive regulation of tumor necrosis factor-mediated signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0031648--P:protein destabilization
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0070585--P:protein localization to mitochondrion
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0050821--P:protein stabilization
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042053--P:regulation of dopamine metabolic process
GO:0051881--P:regulation of mitochondrial membrane potential
GO:0034976--P:response to endoplasmic reticulum stress
GO:0001964--P:startle response
GO:0035249--P:synaptic transmission, glutamatergic

KEGG

gga:421577

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001814	Ailuropoda melanoleuca	69.34	1.00e-110	392.00
IUUC-Apl-003304	Anas platyrhynchos	92.38	0.00e+00	647.00
IUUC-Aca-004908	Anolis carolinensis	80.56	7.00e-54	201.00
IUUC-Ame-011856	Astyanax mexicanus	66.02	0.00e+00	634.00
IUUC-Bta-013014	Bos taurus	71.33	7.00e-165	573.00
IUUC-Bol-016316	Brassica oleracea	29.07	9.00e-15	74.70
IUUC-Cel-018687	Caenorhabditis elegans	31.72	6.00e-42	164.00
IUUC-Cja-019274	Callithrix jacchus	69.18	2.00e-110	391.00
IUUC-Cfa-020461	Canis familiaris	68.97	3.00e-110	390.00
IUUC-Cpo-022251	Cavia porcellus	70.59	2.00e-113	401.00
IUUC-Csa-023112	Chlorocebus sabaeus	69.10	4.00e-108	384.00
IUUC-Cho-024504	Choloepus hoffmanni	53.25	2.00e-125	441.00
IUUC-Cgl-026479	Colletotrichum gloeosporioides	50.98	8.00e-11	62.00
IUUC-Dre-028202	Danio rerio	66.16	4.00e-175	607.00
IUUC-Dno-028946	Dasypus novemcinctus	67.62	2.00e-40	156.00
IUUC-Dor-030508	Dipodomys ordii	59.89	3.00e-113	401.00
IUUC-Dme-031980	Drosophila melanogaster	43.52	3.00e-107	381.00
IUUC-Ete-032281	Echinops telfairi	58.33	3.00e-76	278.00
IUUC-Eca-033228	Equus caballus	69.55	1.00e-112	398.00
IUUC-Fal-037507	Ficedula albicollis	87.45	0.00e+00	820.00
IUUC-Gmo-038744	Gadus morhua	58.39	5.00e-93	334.00
IUUC-Ggr-039963	Gaeumannomyces graminis	47.06	6.00e-09	55.50
IUUC-Gac-042519	Gasterosteus aculeatus	50.74	2.00e-134	472.00
IUUC-Hsa-046016	Homo sapiens	73.35	0.00e+00	678.00
IUUC-Itr-048744	Ictidomys tridecemlineatus	71.37	0.00e+00	652.00
IUUC-Loc-052389	Lepisosteus oculatus	65.58	4.00e-176	610.00
IUUC-Mcc-054933	Macaca mulatta	73.33	0.00e+00	676.00
IUUC-Meu-055963	Macropus eugenii	61.52	1.00e-129	455.00
IUUC-Mpo-057509	Magnaporthe poae	41.18	2.00e-11	62.40
IUUC-Mga-059626	Meleagris gallopavo	94.67	4.00e-38	148.00
IUUC-Mmr-061566	Microcebus murinus	77.73	7.00e-90	322.00
IUUC-Mdo-061952	Monodelphis domestica	87.67	9.00e-31	124.00
IUUC-Mmu-063561	Mus musculus	70.58	0.00e+00	682.00
IUUC-Mpu-065799	Mustela putorius furo	69.66	1.00e-108	385.00
IUUC-Mlu-068134	Myotis lucifugus	67.69	7.00e-132	462.00
IUUC-Nle-070078	Nomascus leucogenys	68.23	2.00e-113	401.00
IUUC-Opr-070541	Ochotona princeps	70.56	4.00e-180	624.00
IUUC-Ont-071743	Oreochromis niloticus	54.55	1.00e-138	486.00
IUUC-Oan-073700	Ornithorhynchus anatinus	77.78	3.00e-21	92.00
IUUC-Ola-086426	Oryzias latipes	59.77	9.00e-63	232.00
IUUC-Oga-088867	Otolemur garnettii	71.71	0.00e+00	654.00
IUUC-Oar-089365	Ovis aries	69.36	7.00e-142	496.00
IUUC-Ptr-091371	Pan troglodytes	73.13	0.00e+00	676.00
IUUC-Pan-092443	Papio anubis	69.10	1.00e-108	385.00
IUUC-Psi-093851	Pelodiscus sinensis	77.31	3.00e-100	357.00
IUUC-Pfo-097194	Poecilia formosa	52.05	1.00e-131	462.00
IUUC-Pab-097999	Pongo abelii	59.71	2.00e-107	381.00
IUUC-Pca-100410	Procavia capensis	68.08	5.00e-163	566.00
IUUC-Pva-102300	Pteropus vampyrus	65.08	1.00e-162	565.00
IUUC-Rno-105556	Rattus norvegicus	66.33	6.00e-106	376.00
IUUC-Sha-106992	Sarcophilus harrisii	81.48	3.00e-22	95.50
IUUC-Ssl-108406	Sclerotinia sclerotiorum	47.73	2.00e-08	53.90
IUUC-Sar-113121	Sorex araneus	81.90	8.00e-56	210.00
IUUC-Ssc-116435	Sus scrofa	67.24	1.00e-108	385.00
IUUC-Tgu-117489	Taeniopygia guttata	86.83	0.00e+00	809.00
IUUC-Tru-117927	Takifugu rubripes	52.16	2.00e-140	492.00
IUUC-Tsy-119372	Tarsius syrichta	77.68	1.00e-151	529.00
IUUC-Tni-120043	Tetraodon nigroviridis	49.79	5.00e-130	457.00
IUUC-Tme-127083	Tuber melanosporum	28.74	4.00e-09	55.50
IUUC-Tbe-127539	Tupaia belangeri	64.79	5.00e-163	567.00
IUUC-Ttr-129149	Tursiops truncatus	69.72	0.00e+00	669.00
IUUC-Vpa-130439	Vicugna pacos	52.90	2.00e-130	458.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence