iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118077

UUCD1 version

UUC-TaR-00659

Ensembl Protein ID

ENSTRUP00000031235.1

UniProt Accession

H2U2S4; H2U2S4_TAKRU

Protein Name

Uncharacterized protein

Gene Name

herc3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000012338.1	ENSTRUT00000031357.1	ENSTRUP00000031235.1
ENSTRUG00000012338.1	ENSTRUT00000031358.1	ENSTRUP00000031236.1
ENSTRUG00000012338.1	ENSTRUT00000031359.1	ENSTRUP00000031237.1
ENSTRUG00000012338.1	ENSTRUT00000031360.1	ENSTRUP00000031238.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.50e-86	290.9	731	1056

Active Site

Position(s)	Description	Evidence
1025	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
            dlkk l+v f gEe++d+gGvt+ef+ ll+kel +p +g+f+++ +++  ++ ++        + k+F+++G+++g+a++++ ++d
   Q: 731  VDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELMDPVYGMFTFHTESNLLWFSDKCFV-----EQKWFHLIGIICGLAIYNSTVVD 812
           589************************************************99888664.....579******************** PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           l+++ ++yk+ll+++ +ledl+e+ p+ ++sl+++ +++ +d+ee+ + ltf ++ e++g t+++eL+pgGe+i V ++N++e+v++
   Q: 813  LHFPLALYKKLLDVSPTLEDLKELSPTEARSLQQLMDYDREDVEEA-FLLTFAITRENYGITEVKELVPGGESIGVDKNNRKEFVEA 898
           **************************************99899887.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket.kykggytedspaiqwFwevleefsseerk 262
           ++ y+++++  eq++af+ Gf +v+  e+lslF++ el  ++ G++++++e ++k     k+++ ++ p    Fwev++efs e++k
   Q: 899  YLRYIFRDSASEQYTAFSTGFLKVCGGEILSLFQPCELMAMVVGNSNYNWEVMEKSFaLLKSDWFSSLPFSXLFWEVFHEFSLEKKK 985
           ******************************************************988466999******99**************** PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +fL F+Tgs+r+P+ G+++l+   ++i+   a+++ lP ++TC+n+L++P+Y++keil+ +L+ A+e+ +gF+l
   Q: 986  QFLLFLTGSDRIPIHGMESLR---IIIQStTAEEHYLPVAHTCYNLLDMPRYQTKEILRCRLTQAVEQYEGFSL 1056
           *********************...7888857777**************************************97 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MLCWGKAKDG QLGIGVERNP MFEPRNCNVF TGRGLKEIVC GGQHSVFLLH DGSVYTCGSN 60
SCGQLGHNKP GITPEFVGAL DTQKITLVSC GQAHSLAVNE QGQVFAWGAG EEGQLGLGTT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTGTGTT GGGGGAAAGC AAAAGATGGG CAGTTGGGTA TTGGAGTGGA GAGGAATCCC 60
ATGTTTGAGC CAAGAAACTG TAACGTGTTC ACTGGCAGGG GCCTGAAAGA AATAGTCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001673	Ailuropoda melanoleuca	63.61	0.00e+00	1311.00
IUUC-Apl-003535	Anas platyrhynchos	64.59	0.00e+00	1319.00
IUUC-Aca-005223	Anolis carolinensis	63.93	0.00e+00	1316.00
IUUC-Ame-010816	Astyanax mexicanus	76.28	0.00e+00	1350.00
IUUC-Bta-013373	Bos taurus	63.61	0.00e+00	1318.00
IUUC-Cja-019609	Callithrix jacchus	63.55	0.00e+00	1309.00
IUUC-Cfa-021071	Canis familiaris	63.46	0.00e+00	1309.00
IUUC-Cpo-021548	Cavia porcellus	63.74	0.00e+00	1310.00
IUUC-Csa-023987	Chlorocebus sabaeus	63.74	0.00e+00	1312.00
IUUC-Cho-024325	Choloepus hoffmanni	69.76	0.00e+00	838.00
IUUC-Dre-027472	Danio rerio	76.37	0.00e+00	1612.00
IUUC-Dno-029241	Dasypus novemcinctus	62.64	0.00e+00	1287.00
IUUC-Dor-030672	Dipodomys ordii	54.21	0.00e+00	629.00
IUUC-Ete-032642	Echinops telfairi	62.38	0.00e+00	1231.00
IUUC-Eca-033646	Equus caballus	63.52	0.00e+00	1305.00
IUUC-Eeu-035098	Erinaceus europaeus	59.57	0.00e+00	793.00
IUUC-Fal-036952	Ficedula albicollis	65.06	0.00e+00	1323.00
IUUC-Gmo-039297	Gadus morhua	74.95	0.00e+00	1551.00
IUUC-Gga-040591	Gallus gallus	64.21	0.00e+00	1311.00
IUUC-Gac-041741	Gasterosteus aculeatus	84.40	0.00e+00	1822.00
IUUC-Ggo-044769	Gorilla gorilla	63.58	0.00e+00	1307.00
IUUC-Hsa-046066	Homo sapiens	63.55	0.00e+00	1308.00
IUUC-Itr-048311	Ictidomys tridecemlineatus	63.49	0.00e+00	1310.00
IUUC-Lch-050301	Latimeria chalumnae	64.52	0.00e+00	1379.00
IUUC-Loc-052803	Lepisosteus oculatus	74.08	0.00e+00	1593.00
IUUC-Laf-053364	Loxodonta africana	63.89	0.00e+00	1313.00
IUUC-Mcc-054930	Macaca mulatta	63.74	0.00e+00	1311.00
IUUC-Meu-056274	Macropus eugenii	52.55	3.00e-152	532.00
IUUC-Mga-059563	Meleagris gallopavo	64.49	0.00e+00	1320.00
IUUC-Mmr-060792	Microcebus murinus	62.85	0.00e+00	1286.00
IUUC-Mdo-062195	Monodelphis domestica	64.28	0.00e+00	1316.00
IUUC-Mmu-063855	Mus musculus	63.42	0.00e+00	1311.00
IUUC-Mpu-066308	Mustela putorius furo	63.71	0.00e+00	1313.00
IUUC-Mlu-066927	Myotis lucifugus	63.55	0.00e+00	1312.00
IUUC-Nle-070090	Nomascus leucogenys	63.64	0.00e+00	1311.00
IUUC-Opr-070891	Ochotona princeps	56.90	0.00e+00	1101.00
IUUC-Ont-072201	Oreochromis niloticus	83.43	0.00e+00	1787.00
IUUC-Ocu-074770	Oryctolagus cuniculus	63.93	0.00e+00	1312.00
IUUC-Ola-086550	Oryzias latipes	82.02	0.00e+00	1788.00
IUUC-Oga-088831	Otolemur garnettii	63.17	0.00e+00	1298.00
IUUC-Oar-090449	Ovis aries	63.74	0.00e+00	1316.00
IUUC-Pan-092135	Papio anubis	63.83	0.00e+00	1313.00
IUUC-Psi-093832	Pelodiscus sinensis	63.36	0.00e+00	1330.00
IUUC-Pfo-097268	Poecilia formosa	83.93	0.00e+00	1813.00
IUUC-Pab-098249	Pongo abelii	63.46	0.00e+00	1308.00
IUUC-Pca-100855	Procavia capensis	57.97	0.00e+00	850.00
IUUC-Pva-102506	Pteropus vampyrus	61.16	0.00e+00	1125.00
IUUC-Rno-105242	Rattus norvegicus	63.61	0.00e+00	1347.00
IUUC-Sar-113612	Sorex araneus	71.32	1.00e-156	547.00
IUUC-Ssc-115473	Sus scrofa	63.80	0.00e+00	1315.00
IUUC-Tgu-116974	Taeniopygia guttata	65.16	0.00e+00	1308.00
IUUC-Tsy-119619	Tarsius syrichta	55.05	0.00e+00	1126.00
IUUC-Tni-120807	Tetraodon nigroviridis	91.51	0.00e+00	1958.00
IUUC-Tbe-127640	Tupaia belangeri	61.34	0.00e+00	1229.00
IUUC-Ttr-129172	Tursiops truncatus	63.42	0.00e+00	1304.00
IUUC-Xtr-132194	Xenopus tropicalis	56.89	0.00e+00	1071.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence