iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020039

Ensembl Protein ID

ENSCAFP00000014425.3

UniProt Accession

F1P9K0; F1P9K0_CANLF

Genbank Protein ID

ENSCAFP00000014425

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03001616

Gene Name

NOD2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000009818.3	ENSCAFT00000015589.3	ENSCAFP00000014425.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/CARD	1.10e-15	58.2	141	198

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/CARD

   S: 3    eeyrlllstlqdrvrklLdvtdvldkylseflleeekelilaaaetkgnmqaaelLLkt 61
           +e+rl+++t ++r+r+lLd+++v++++l++fll +++el+++ a ++++++++ + ++ 
   Q: 141  DEIRLPIFTSSQRARRLLDLATVKANGLAAFLLRHVQELPVPLAMPSEDAACK-KYMSK 198
           8***************************************************9.55554 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MCTQEAFQTQ RSQLVGLLVS GSLEGFESIL DWLLSWEVLS WEDYEGLSLL GQPLSYLARR 60
LLDTVWNKGT WGCEQLVAAV REAQTDCQAL ELSSCWDPHS PHPARDLQSH RPAIVRRLYS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGATGTGGA AACCAGGAGC CTTGATTGAA TTCCTGGCCA CTTCAAACTC TCTGTGGGAG 60
CTCAAGCCAA TTTCTTTCTT TCTTTCTTTT TTTTTTTTTT TAAGATTTTA TTTATTTATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome

Interpro

IPR001315--CARD
IPR011029--DEATH-like_dom
IPR001611--Leu-rich_rpt
IPR007111--NACHT_NTPase
IPR027417--P-loop_NTPase

PROSITE

PS50209--CARD
PS51450--LRR
PS50837--NACHT

Pfam

PF00619--CARD
PF13516--LRR_6

Gene Ontology

GO:0016323--C:basolateral plasma membrane
GO:0009986--C:cell surface
GO:0008180--C:COP9 signalosome
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0031982--C:vesicle
GO:0005524--F:ATP binding
GO:0032500--F:muramyl dipeptide binding
GO:0042834--F:peptidoglycan binding
GO:0071225--P:cellular response to muramyl dipeptide
GO:0002374--P:cytokine secretion involved in immune response
GO:0042742--P:defense response to bacterium
GO:0016045--P:detection of bacterium
GO:0032498--P:detection of muramyl dipeptide
GO:0045087--P:innate immune response
GO:0030277--P:maintenance of gastrointestinal epithelium
GO:0070431--P:nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0050871--P:positive regulation of B cell activation
GO:1900017--P:positive regulation of cytokine production involved in inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050718--P:positive regulation of interleukin-1 beta secretion
GO:0032740--P:positive regulation of interleukin-17 production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0032757--P:positive regulation of interleukin-8 production
GO:0046330--P:positive regulation of JNK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0002830--P:positive regulation of type 2 immune response
GO:0042981--P:regulation of apoptotic process

KEGG

cfa:487286

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001822	Ailuropoda melanoleuca	88.06	0.00e+00	1586.00
IUUC-Ame-011021	Astyanax mexicanus	46.65	0.00e+00	884.00
IUUC-Bta-013241	Bos taurus	82.53	0.00e+00	1617.00
IUUC-Cja-019633	Callithrix jacchus	79.12	0.00e+00	1178.00
IUUC-Cpo-022337	Cavia porcellus	77.37	0.00e+00	1464.00
IUUC-Csa-023906	Chlorocebus sabaeus	82.92	0.00e+00	1618.00
IUUC-Dre-027568	Danio rerio	48.01	0.00e+00	830.00
IUUC-Dno-029098	Dasypus novemcinctus	79.98	0.00e+00	1449.00
IUUC-Dor-031102	Dipodomys ordii	72.65	0.00e+00	669.00
IUUC-Ete-032943	Echinops telfairi	75.97	0.00e+00	1089.00
IUUC-Eca-034310	Equus caballus	85.29	0.00e+00	1606.00
IUUC-Eeu-034589	Erinaceus europaeus	78.48	4.00e-165	575.00
IUUC-Fca-036252	Felis catus	86.61	0.00e+00	851.00
IUUC-Gac-041442	Gasterosteus aculeatus	46.89	0.00e+00	844.00
IUUC-Ggo-044861	Gorilla gorilla	83.51	0.00e+00	1585.00
IUUC-Hsa-046093	Homo sapiens	83.42	0.00e+00	1582.00
IUUC-Itr-048543	Ictidomys tridecemlineatus	79.62	0.00e+00	1433.00
IUUC-Lch-049454	Latimeria chalumnae	54.58	0.00e+00	931.00
IUUC-Laf-053553	Loxodonta africana	81.93	0.00e+00	1456.00
IUUC-Mcc-055772	Macaca mulatta	83.22	0.00e+00	1597.00
IUUC-Meu-056785	Macropus eugenii	70.21	1.00e-116	414.00
IUUC-Mmr-060596	Microcebus murinus	81.24	0.00e+00	1521.00
IUUC-Mdo-062983	Monodelphis domestica	67.67	0.00e+00	1111.00
IUUC-Mmu-063951	Mus musculus	74.30	0.00e+00	1455.00
IUUC-Mpu-066412	Mustela putorius furo	88.45	0.00e+00	1713.00
IUUC-Mlu-067601	Myotis lucifugus	80.43	0.00e+00	1444.00
IUUC-Nle-069913	Nomascus leucogenys	83.55	0.00e+00	1334.00
IUUC-Opr-070999	Ochotona princeps	80.37	0.00e+00	929.00
IUUC-Ont-072512	Oreochromis niloticus	46.89	0.00e+00	892.00
IUUC-Oan-073564	Ornithorhynchus anatinus	61.82	0.00e+00	1100.00
IUUC-Ocu-074837	Oryctolagus cuniculus	84.01	0.00e+00	1590.00
IUUC-Ola-086555	Oryzias latipes	46.61	0.00e+00	823.00
IUUC-Oga-088909	Otolemur garnettii	80.85	0.00e+00	1525.00
IUUC-Oar-089315	Ovis aries	81.85	0.00e+00	1559.00
IUUC-Ptr-090542	Pan troglodytes	83.42	0.00e+00	1583.00
IUUC-Pan-092545	Papio anubis	83.22	0.00e+00	1592.00
IUUC-Pma-094167	Petromyzon marinus	33.07	3.00e-63	236.00
IUUC-Ppa-095344	Physcomitrella patens	34.18	3.00e-04	41.20
IUUC-Pfo-096976	Poecilia formosa	45.19	0.00e+00	845.00
IUUC-Pab-098481	Pongo abelii	83.12	0.00e+00	1572.00
IUUC-Pca-100135	Procavia capensis	76.35	0.00e+00	1290.00
IUUC-Pva-102127	Pteropus vampyrus	82.03	0.00e+00	1455.00
IUUC-Rno-105783	Rattus norvegicus	76.36	0.00e+00	1448.00
IUUC-Sar-113448	Sorex araneus	75.43	0.00e+00	939.00
IUUC-Tru-118708	Takifugu rubripes	44.90	0.00e+00	787.00
IUUC-Tni-120172	Tetraodon nigroviridis	35.43	3.00e-32	132.00
IUUC-Tbe-127661	Tupaia belangeri	80.72	0.00e+00	780.00
IUUC-Ttr-128318	Tursiops truncatus	77.49	0.00e+00	1392.00
IUUC-Vpa-130502	Vicugna pacos	76.19	1.00e-161	563.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence