iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eeu-034616

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Kelch-like protein 15

Genbank Nucleotide ID

GU301728

Gene Name

KLHL22; KLHL15

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSEEUG00000009380.1	ENSEEUT00000009365.1	ENSEEUP00000008540.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	1.70e-06	27.9	51	76
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	2.60e-08	33.1	150	179

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 2    DvilvvggeeffahkivLaasSsvFy 27
           Dv+lvv+g++++ah+i Laas+++F 
   Q: 51   DVVLVVEGRHIEAHRILLAASCDYFX 76
           9************************6 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 2    eNclgilrfAdlydcpdLkdaaldfilkhF 31
           eN l+++r+A+l+d+++L d+ +++ilk+F
   Q: 150  ENILDVYRLAELFDLSRLTDQLDTYILKNF 179
           8***************************** PP

Organism

Erinaceus europaeus

Protein Sequence
(Fasta)

MAEDQEFTQL CKLPSQPAHP HCVNNTYRSA QHSQALLRGL LALRDSGILF DVVLVVEGRH 60
IEAHRILLAA SCDYFXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGAAG ATCAGGAGTT CACCCAGCTT TGCAAATTGC CCTCCCAGCC AGCACACCCA 60
CACTGTGTTA ACAACACCTA CCGCAGCGCA CAGCACTCCC AGGCGCTGCT TCGGGGCTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Interpro

IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030597--KLHL15

Pfam

PF01344--Kelch_1

SMART

SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005634--C:nucleus
GO:2000042--P:negative regulation of double-strand break repair via homologous recombination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0071630--P:ubiquitin-dependent catabolism of misfolded proteins by nucleus-associated proteasome

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002097	Ailuropoda melanoleuca	85.49	0.00e+00	1063.00
IUUC-Apl-004081	Anas platyrhynchos	69.44	0.00e+00	894.00
IUUC-Aca-005015	Anolis carolinensis	58.43	0.00e+00	731.00
IUUC-Ame-011712	Astyanax mexicanus	53.30	0.00e+00	627.00
IUUC-Bta-012594	Bos taurus	81.86	0.00e+00	1053.00
IUUC-Bci-013875	Botrytis cinerea	30.00	1.00e-18	86.70
IUUC-Cja-019752	Callithrix jacchus	94.04	0.00e+00	994.00
IUUC-Cfa-020884	Canis familiaris	85.49	0.00e+00	1099.00
IUUC-Cpo-021711	Cavia porcellus	84.86	0.00e+00	1093.00
IUUC-Csa-023211	Chlorocebus sabaeus	86.44	0.00e+00	1107.00
IUUC-Dre-028395	Danio rerio	53.23	0.00e+00	653.00
IUUC-Dno-030096	Dasypus novemcinctus	82.29	0.00e+00	1055.00
IUUC-Dor-030709	Dipodomys ordii	78.11	7.00e-160	556.00
IUUC-Eca-033388	Equus caballus	85.33	0.00e+00	1099.00
IUUC-Fca-035815	Felis catus	85.33	0.00e+00	1098.00
IUUC-Fal-037311	Ficedula albicollis	71.06	0.00e+00	872.00
IUUC-Gmo-039571	Gadus morhua	45.83	9.00e-128	449.00
IUUC-Gga-040992	Gallus gallus	69.28	0.00e+00	895.00
IUUC-Gac-042041	Gasterosteus aculeatus	52.85	4.00e-171	594.00
IUUC-Ggo-045141	Gorilla gorilla	86.44	0.00e+00	1104.00
IUUC-Hsa-045984	Homo sapiens	86.44	0.00e+00	1108.00
IUUC-Itr-048890	Ictidomys tridecemlineatus	85.65	0.00e+00	1103.00
IUUC-Lch-049700	Latimeria chalumnae	52.83	1.00e-176	612.00
IUUC-Loc-052141	Lepisosteus oculatus	55.05	0.00e+00	715.00
IUUC-Laf-053487	Loxodonta africana	83.49	0.00e+00	1057.00
IUUC-Mcc-054682	Macaca mulatta	84.24	0.00e+00	865.00
IUUC-Meu-055937	Macropus eugenii	81.97	0.00e+00	952.00
IUUC-Mga-059953	Meleagris gallopavo	69.28	0.00e+00	895.00
IUUC-Mmr-061743	Microcebus murinus	85.65	0.00e+00	1096.00
IUUC-Mdo-062328	Monodelphis domestica	73.67	0.00e+00	954.00
IUUC-Mmu-063979	Mus musculus	82.14	0.00e+00	1044.00
IUUC-Mpu-066750	Mustela putorius furo	85.33	0.00e+00	1097.00
IUUC-Mlu-066960	Myotis lucifugus	85.17	0.00e+00	1087.00
IUUC-Nle-069690	Nomascus leucogenys	94.63	0.00e+00	1002.00
IUUC-Opr-071059	Ochotona princeps	78.58	0.00e+00	982.00
IUUC-Ont-072004	Oreochromis niloticus	53.20	4.00e-173	600.00
IUUC-Oan-073172	Ornithorhynchus anatinus	56.13	0.00e+00	631.00
IUUC-Ocu-074310	Oryctolagus cuniculus	93.18	7.00e-151	525.00
IUUC-Ola-086599	Oryzias latipes	52.17	1.00e-178	619.00
IUUC-Oga-087980	Otolemur garnettii	85.33	0.00e+00	1094.00
IUUC-Oar-089956	Ovis aries	76.89	0.00e+00	682.00
IUUC-Ptr-090598	Pan troglodytes	94.43	0.00e+00	1000.00
IUUC-Pan-092387	Papio anubis	83.85	0.00e+00	862.00
IUUC-Psi-093484	Pelodiscus sinensis	70.53	0.00e+00	929.00
IUUC-Pma-094224	Petromyzon marinus	44.70	6.00e-149	520.00
IUUC-Pfo-096149	Poecilia formosa	52.37	0.00e+00	627.00
IUUC-Pab-098097	Pongo abelii	86.28	0.00e+00	1108.00
IUUC-Pca-100118	Procavia capensis	77.57	8.00e-159	553.00
IUUC-Pva-103174	Pteropus vampyrus	92.78	7.00e-151	526.00
IUUC-Rno-105350	Rattus norvegicus	82.31	0.00e+00	1029.00
IUUC-Sce-106328	Saccharomyces cerevisiae	26.26	2.50e+00	26.60
IUUC-Sha-106817	Sarcophilus harrisii	82.02	1.00e-133	469.00
IUUC-Sar-113490	Sorex araneus	78.13	2.00e-144	505.00
IUUC-Ssc-115827	Sus scrofa	84.07	0.00e+00	1085.00
IUUC-Tgu-116748	Taeniopygia guttata	71.86	0.00e+00	767.00
IUUC-Tru-118644	Takifugu rubripes	51.28	3.00e-175	607.00
IUUC-Tsy-118888	Tarsius syrichta	86.48	0.00e+00	897.00
IUUC-Tni-120060	Tetraodon nigroviridis	48.17	2.00e-148	518.00
IUUC-Ttr-129183	Tursiops truncatus	91.45	0.00e+00	971.00
IUUC-Xtr-132780	Xenopus tropicalis	60.47	0.00e+00	776.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence