iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-021234

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03005423

Gene Name

RNF125

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000031870.1	ENSCAFT00000044835.1	ENSCAFP00000043160.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	2.00e-10	40.9	33	98
E3 activity/RING/RING	1.40e-08	35.5	37	76

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawc 69
             f C++ le+ ++Pv + +G+++ rs+I+  l++++ tcP +r+ l +e +    + +r+ +++ 
   Q: 33   TSFDCSVCLEVLHQPVRTRCGHVFCRSCIATSLKNNRWTCPYCRAYLPSEGVPATDVAKRMKSEYQ 98
           579**********************************9*********9999999999999999885 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C++Cle + + p+ ++CgHvf+++C+   +      ++++++CP+Cr
   Q: 37   CSVCLEVLHQ-PVRTRCGHVFCRSCIaTSL------KNNRWTCPYCR 76
           ********99.777***********95555......**********8 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MGSVLSSDSA KAAPASGAPR ALERSGDPEL PVTSFDCSVC LEVLHQPVRT RCGHVFCRSC 60
IATSLKNNRW TCPYCRAYLP SEGVPATDVA KRMKSEYQNC TECDTLVCLS EMRAHIRSCQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGGATCCGA ACCCGGGTCT CAGAACCTTT TGCACGCCGC GTGCTAGCCC TCCCCCCGTG 60
GGCGCCGACT GCGGCCCGAG CGCAGGGGGG CGCGGTCTCG GGAGCCGCTC GGTGCCAGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR008598--Di19_Zn_binding_dom
IPR034734--ZF_C2HC_RNF
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51803--ZF_C2HC_RNF
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF05605--zf-Di19

SMART

SM00184--RING

Gene Ontology

GO:0000139--C:Golgi membrane
GO:0005622--C:intracellular
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0039536--P:negative regulation of RIG-I signaling pathway
GO:0032480--P:negative regulation of type I interferon production
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001992	Ailuropoda melanoleuca	96.98	4.00e-134	470.00
IUUC-Aca-004839	Anolis carolinensis	63.69	1.00e-67	248.00
IUUC-Bta-012827	Bos taurus	89.61	3.00e-124	437.00
IUUC-Cja-018794	Callithrix jacchus	90.95	5.00e-126	443.00
IUUC-Cpo-022412	Cavia porcellus	80.60	2.00e-106	377.00
IUUC-Csa-023406	Chlorocebus sabaeus	91.38	1.00e-126	445.00
IUUC-Cho-024427	Choloepus hoffmanni	76.27	3.00e-75	274.00
IUUC-Dno-030085	Dasypus novemcinctus	90.52	8.00e-126	442.00
IUUC-Dor-030911	Dipodomys ordii	68.53	1.00e-74	272.00
IUUC-Ete-032469	Echinops telfairi	85.34	2.00e-118	417.00
IUUC-Eca-034352	Equus caballus	93.53	2.00e-129	454.00
IUUC-Eeu-034889	Erinaceus europaeus	76.72	1.00e-100	358.00
IUUC-Fca-036116	Felis catus	96.12	4.00e-126	443.00
IUUC-Hsa-046518	Homo sapiens	90.95	1.00e-125	441.00
IUUC-Itr-048344	Ictidomys tridecemlineatus	96.05	8.00e-101	358.00
IUUC-Laf-053363	Loxodonta africana	90.60	1.00e-125	442.00
IUUC-Meu-056101	Macropus eugenii	79.71	1.00e-96	345.00
IUUC-Mdo-062046	Monodelphis domestica	75.97	4.00e-100	357.00
IUUC-Mmu-063184	Mus musculus	82.86	2.00e-57	214.00
IUUC-Mpu-065708	Mustela putorius furo	94.83	4.00e-131	459.00
IUUC-Mlu-067561	Myotis lucifugus	87.57	5.00e-93	332.00
IUUC-Nle-069665	Nomascus leucogenys	90.19	5.00e-115	406.00
IUUC-Opr-070301	Ochotona princeps	78.88	3.00e-105	374.00
IUUC-Ocu-074562	Oryctolagus cuniculus	92.86	1.00e-66	244.00
IUUC-Oga-088958	Otolemur garnettii	91.81	9.00e-128	448.00
IUUC-Oar-089541	Ovis aries	90.40	9.00e-96	342.00
IUUC-Ptr-090989	Pan troglodytes	91.38	1.00e-126	444.00
IUUC-Pan-092372	Papio anubis	90.52	7.00e-126	442.00
IUUC-Pab-098718	Pongo abelii	78.45	9.00e-102	362.00
IUUC-Pca-100453	Procavia capensis	88.79	9.00e-123	432.00
IUUC-Pva-102931	Pteropus vampyrus	91.38	6.00e-119	419.00
IUUC-Rno-105771	Rattus norvegicus	88.21	2.00e-101	361.00
IUUC-Sha-107557	Sarcophilus harrisii	75.54	3.00e-106	377.00
IUUC-Sja-107981	Schizosaccharomyces japonicus	48.28	1.00e-08	53.50
IUUC-Spo-108312	Schizosaccharomyces pombe	40.98	3.00e-08	52.40
IUUC-Sar-113435	Sorex araneus	95.24	2.00e-69	253.00
IUUC-Ssc-116388	Sus scrofa	93.10	5.00e-130	456.00
IUUC-Tsy-119439	Tarsius syrichta	93.22	1.00e-98	351.00
IUUC-Tbe-127417	Tupaia belangeri	66.67	7.00e-71	259.00
IUUC-Ttr-129212	Tursiops truncatus	92.67	3.00e-129	453.00
IUUC-Vpa-130153	Vicugna pacos	90.09	5.00e-126	442.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence