iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
ICGC	COSMIC	CGAP	IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
THPA	HPM
DNA & RNA Element
UTRdb	TRANSFAC	miRcode
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	11850190; 17071595; 12525704

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.036	16.2	11	52

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C++Cl d+++  + l Cg + +++Cl+ +  +k       +C  C
   Q: 11   CPVCLKDLEE-AVQLKCGYACCLQCLNSL--QKEPDGEGLLCRFC 52
           ********99.888************888..22224444445555 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAEHFKQIIR CPVCLKDLEE AVQLKCGYAC CLQCLNSLQK EPDGEGLLCR FCSVVSQKDD 60
IKPKYKLRAL VSIIKELEPK LKSVLTMNPR MRKFQVDMTF DVDTANNYLI ISEDLRSFRS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAATCAG AATCTGATTG GATTAAAAAG GAGGGAAAGG GTGTGGCTAA GGTGGGTGGA 60
GACACCCTCT GGTATAAAAG CCCCTGGCAG GCAGCTCTCA CTCCAGATCT GAGCTGTCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR022723--RDM_domain_RFPL
IPR003877--SPRY_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50188--B302_SPRY
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF11002--RDM
PF00622--SPRY

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00589--PRY
SM00449--SPRY

Gene Ontology

GO:0008270--F:zinc ion binding

KEGG

hsa:342931

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001691	Ailuropoda melanoleuca	61.05	4.00e-100	357.00
IUUC-Cja-019648	Callithrix jacchus	74.05	7.00e-123	433.00
IUUC-Cfa-021157	Canis familiaris	61.40	2.00e-102	365.00
IUUC-Csa-023392	Chlorocebus sabaeus	88.03	1.00e-154	538.00
IUUC-Cho-024388	Choloepus hoffmanni	59.30	8.00e-97	346.00
IUUC-Dno-029913	Dasypus novemcinctus	59.93	3.00e-97	348.00
IUUC-Eca-034420	Equus caballus	65.85	7.00e-109	386.00
IUUC-Fca-035881	Felis catus	62.32	2.00e-102	365.00
IUUC-Ggo-044905	Gorilla gorilla	70.57	1.00e-116	412.00
IUUC-Itr-048717	Ictidomys tridecemlineatus	52.75	1.00e-74	273.00
IUUC-Laf-054470	Loxodonta africana	60.84	2.00e-98	352.00
IUUC-Mcc-055311	Macaca mulatta	80.49	2.00e-134	471.00
IUUC-Mmr-061421	Microcebus murinus	61.02	3.00e-90	324.00
IUUC-Mmu-063319	Mus musculus	54.70	1.00e-85	309.00
IUUC-Mpu-066753	Mustela putorius furo	59.86	1.00e-94	339.00
IUUC-Mlu-067367	Myotis lucifugus	54.44	2.00e-84	305.00
IUUC-Nle-070151	Nomascus leucogenys	86.27	7.00e-150	523.00
IUUC-Opr-070352	Ochotona princeps	54.68	4.00e-75	274.00
IUUC-Oan-073338	Ornithorhynchus anatinus	38.97	7.00e-52	197.00
IUUC-Ocu-074070	Oryctolagus cuniculus	56.23	8.00e-92	330.00
IUUC-Oga-088520	Otolemur garnettii	59.85	3.00e-96	344.00
IUUC-Oar-089895	Ovis aries	44.40	4.00e-54	204.00
IUUC-Ptr-090888	Pan troglodytes	98.15	1.00e-159	555.00
IUUC-Pan-091913	Papio anubis	89.44	1.00e-156	545.00
IUUC-Pab-097712	Pongo abelii	92.51	1.00e-149	522.00
IUUC-Pva-103224	Pteropus vampyrus	53.36	9.00e-78	283.00
IUUC-Rno-104962	Rattus norvegicus	55.83	5.00e-92	330.00
IUUC-Ssc-115725	Sus scrofa	59.01	7.00e-96	343.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence