iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052604

Ensembl Protein ID

ENSLOCP00000003647.1

UniProt Accession

W5M5I9; W5M5I9_LEPOC

Genbank Protein ID

ENSLOCP00000003647

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AHAT01010575

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000003079.1	ENSLOCT00000003654.1	ENSLOCP00000003647.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.10e-133	443.1	554	886

Active Site

Position(s)	Description	Evidence
855	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 554  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 641
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+kk +l+dle++dpe+++s++++ken   ++ee+g++l f ++ eilg+++++eLk++Gen+ Vt++NkeeY++l+++
   Q: 642  GFTLPFYKRMLNKKPTLKDLESIDPEFHNSIMWVKEN---NLEECGVELYFAQDMEILGKVSTHELKTDGENELVTEDNKEEYIRLLTD 727
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev+ple+l++F+e+elel++cG++eid+ d++k+t y++ yt++s++iqwFw+v++e+++e+r ++LqFv
   Q: 728  WRFTRGVEEQTKAFLDGFNEVVPLEWLRYFDEKELELMLCGMQEIDLTDWQKNTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFV 815
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGf el     p++f+i k +++++lP+s+TCfn+L+LP+Y+s e+lkekLl+Aieet+gF++
   Q: 816  TGTCRLPVGGFSELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSFEQLKEKLLFAIEETEGFGQ 886
           *********************************************************************96 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MASASSSRSG VGQSSEKSQL TLKVLSAKPQ SPKSPSRHSR LNSFVEVTAD GLSSETKKTG 60
KRCGHPELQW NEDLTLNVTP QSHLDLKLWS CHALRNELLG IASIDVYDTL KSNNGKMENV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCTGGACAA TGCCACCTCC TGACTTGGAT TCTCCAACTG GTGTGGTGCA GTTGGCAGGG 60
AGCCTCTGTG GTATTGTGTT CCTTAGCTGG GCAGGGCCTG CTTGAATTCC AGAGAAACTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0060021--P:palate development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	74.58	0.00e+00	1303.00
IUUC-Apl-003912	Anas platyrhynchos	69.36	0.00e+00	1109.00
IUUC-Aca-004291	Anolis carolinensis	74.75	0.00e+00	1303.00
IUUC-Bta-013231	Bos taurus	91.39	0.00e+00	1109.00
IUUC-Cja-019455	Callithrix jacchus	75.82	0.00e+00	1328.00
IUUC-Cfa-021017	Canis familiaris	74.75	0.00e+00	1304.00
IUUC-Cpo-021988	Cavia porcellus	74.86	0.00e+00	1334.00
IUUC-Csa-023549	Chlorocebus sabaeus	75.93	0.00e+00	1338.00
IUUC-Dre-028513	Danio rerio	79.18	0.00e+00	1379.00
IUUC-Dno-028976	Dasypus novemcinctus	75.48	0.00e+00	1332.00
IUUC-Dor-030176	Dipodomys ordii	74.51	0.00e+00	1259.00
IUUC-Eca-033949	Equus caballus	74.38	0.00e+00	1311.00
IUUC-Eeu-034529	Erinaceus europaeus	80.14	0.00e+00	949.00
IUUC-Fca-036236	Felis catus	75.20	0.00e+00	1321.00
IUUC-Fal-036948	Ficedula albicollis	91.65	0.00e+00	1120.00
IUUC-Gmo-038842	Gadus morhua	90.86	0.00e+00	1070.00
IUUC-Gga-040617	Gallus gallus	82.54	0.00e+00	1131.00
IUUC-Gac-041338	Gasterosteus aculeatus	73.49	0.00e+00	1300.00
IUUC-Ggo-045278	Gorilla gorilla	76.04	0.00e+00	1337.00
IUUC-Hsa-046148	Homo sapiens	76.15	0.00e+00	1341.00
IUUC-Lch-050663	Latimeria chalumnae	77.81	0.00e+00	1390.00
IUUC-Laf-053944	Loxodonta africana	75.31	0.00e+00	1328.00
IUUC-Mcc-055655	Macaca mulatta	75.93	0.00e+00	1340.00
IUUC-Meu-055953	Macropus eugenii	78.42	0.00e+00	954.00
IUUC-Mga-060190	Meleagris gallopavo	73.35	0.00e+00	1287.00
IUUC-Mmr-060896	Microcebus murinus	74.47	0.00e+00	1305.00
IUUC-Mdo-062536	Monodelphis domestica	76.77	0.00e+00	1343.00
IUUC-Mmu-064017	Mus musculus	73.82	0.00e+00	1325.00
IUUC-Mpu-066608	Mustela putorius furo	70.99	0.00e+00	1252.00
IUUC-Mlu-067623	Myotis lucifugus	73.52	0.00e+00	1278.00
IUUC-Nle-069496	Nomascus leucogenys	74.27	0.00e+00	1293.00
IUUC-Opr-071054	Ochotona princeps	85.26	0.00e+00	1103.00
IUUC-Ont-071279	Oreochromis niloticus	77.97	0.00e+00	1355.00
IUUC-Oan-073512	Ornithorhynchus anatinus	74.83	0.00e+00	1274.00
IUUC-Ocu-074271	Oryctolagus cuniculus	75.00	0.00e+00	1300.00
IUUC-Ola-087237	Oryzias latipes	72.49	0.00e+00	1278.00
IUUC-Oga-088164	Otolemur garnettii	75.56	0.00e+00	1330.00
IUUC-Oar-089698	Ovis aries	74.25	0.00e+00	1301.00
IUUC-Ptr-091306	Pan troglodytes	75.14	0.00e+00	1313.00
IUUC-Pan-092814	Papio anubis	72.73	0.00e+00	1259.00
IUUC-Pfo-096709	Poecilia formosa	76.33	0.00e+00	1314.00
IUUC-Pab-098494	Pongo abelii	75.48	0.00e+00	1321.00
IUUC-Pca-100596	Procavia capensis	92.32	0.00e+00	922.00
IUUC-Pva-103154	Pteropus vampyrus	74.33	0.00e+00	1251.00
IUUC-Rno-104954	Rattus norvegicus	75.80	0.00e+00	1153.00
IUUC-Sha-106781	Sarcophilus harrisii	76.57	0.00e+00	1358.00
IUUC-Ssc-116307	Sus scrofa	67.40	0.00e+00	1140.00
IUUC-Tgu-116530	Taeniopygia guttata	76.13	0.00e+00	1016.00
IUUC-Tru-118287	Takifugu rubripes	91.24	0.00e+00	1065.00
IUUC-Tni-120801	Tetraodon nigroviridis	72.58	0.00e+00	1241.00
IUUC-Tbe-127793	Tupaia belangeri	66.37	0.00e+00	1117.00
IUUC-Ttr-128275	Tursiops truncatus	74.19	0.00e+00	1302.00
IUUC-Xtr-132866	Xenopus tropicalis	81.90	0.00e+00	1091.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence