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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046978
UUCD1 version UUC-HoS-00478
Ensembl Protein ID ENSP00000355437.3
UniProt Accession Q8NG06; Q6B0H9; TRI58_HUMAN
Genbank Protein ID AAM63958.1; AAH74748.1
Protein Name E3 ubiquitin-protein ligase TRIM58; Protein BIA2; RING-type E3 ubiquitin transferase TRIM58; Tripartite motif-containing protein 58
Genbank Nucleotide ID AF327057; BC074748
Gene Name TRIM58
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000162722.8 ENST00000366481.3 ENSP00000355437.3
Annotation
Cancer Mutation
TCGAICGCCOSMICIntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Variation
ClinVarGWASdbGWAS Central
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 7.00e-06 28.1 16 61
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw.pglknssskefrCPlCr 46
           C++Cl+ +++ p++++CgH f++ C+  +   +   + +   CP Cr
   Q: 16   CPVCLDFLQE-PVSVDCGHSFCLRCISEFcEKSDGAQGGVYACPQCR 61
           ********99.***************9995444555666779****8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization.
 E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization.
Protein Sequence
(Fasta)
MAWAPPGERL REDARCPVCL DFLQEPVSVD CGHSFCLRCI SEFCEKSDGA QGGVYACPQC 60
RGPFRPSGFR PNRQLAGLVE SVRRLGLGAG PGARRCARHG EDLSRFCEED EAALCWVCDA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046978|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
GGGAGACGGT GCGGGCGGCC GGGAGCGCAG CCCTCCGGGA GGCGGGTCAT GGCCTGGGCG 60
CCGCCCGGGG AGCGGCTGCG CGAGGATGCG CGGTGCCCGG TGTGCCTGGA TTTCCTGCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046978|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box
PRINTS

PR01407--BUTYPHLNCDUF
SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY
Gene Ontology

GO:0005622--C:intracellular
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0016567--P:protein ubiquitination
KEGG hsa:25893
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001785 Ailuropoda melanoleuca 73.96 0.00e+00 676.00
IUUC-Aca-004891 Anolis carolinensis 43.62 2.00e-97 349.00
IUUC-Bta-012726 Bos taurus 82.53 0.00e+00 724.00
IUUC-Cja-018951 Callithrix jacchus 86.33 0.00e+00 759.00
IUUC-Cfa-021114 Canis familiaris 81.31 0.00e+00 773.00
IUUC-Cpo-021630 Cavia porcellus 66.38 1.00e-163 569.00
IUUC-Cho-024849 Choloepus hoffmanni 79.73 2.00e-114 405.00
IUUC-Dno-029530 Dasypus novemcinctus 80.51 0.00e+00 711.00
IUUC-Eeu-035044 Erinaceus europaeus 80.93 2.00e-111 396.00
IUUC-Fca-035988 Felis catus 80.04 0.00e+00 756.00
IUUC-Laf-054172 Loxodonta africana 82.14 0.00e+00 773.00
IUUC-Mdo-062418 Monodelphis domestica 62.85 5.00e-174 603.00
IUUC-Mmu-063326 Mus musculus 79.58 0.00e+00 723.00
IUUC-Mpu-066338 Mustela putorius furo 78.56 0.00e+00 708.00
IUUC-Mlu-067864 Myotis lucifugus 70.40 3.00e-176 611.00
IUUC-Nle-069883 Nomascus leucogenys 94.86 0.00e+00 904.00
IUUC-Opr-070347 Ochotona princeps 67.03 5.00e-159 553.00
IUUC-Oan-073120 Ornithorhynchus anatinus 52.56 7.00e-117 414.00
IUUC-Ocu-074489 Oryctolagus cuniculus 73.27 2.00e-113 402.00
IUUC-Oga-087926 Otolemur garnettii 80.04 0.00e+00 766.00
IUUC-Oar-090340 Ovis aries 82.06 0.00e+00 739.00
IUUC-Ptr-091292 Pan troglodytes 96.91 0.00e+00 860.00
IUUC-Pan-092710 Papio anubis 94.44 0.00e+00 811.00
IUUC-Pab-098011 Pongo abelii 96.50 0.00e+00 862.00
IUUC-Pca-100277 Procavia capensis 80.59 2.00e-113 402.00
IUUC-Pva-103101 Pteropus vampyrus 82.47 0.00e+00 785.00
IUUC-Rno-105618 Rattus norvegicus 79.79 0.00e+00 728.00
IUUC-Sha-106630 Sarcophilus harrisii 60.13 3.00e-160 558.00
IUUC-Ssc-116382 Sus scrofa 81.46 0.00e+00 737.00
IUUC-Tsy-119220 Tarsius syrichta 74.28 4.00e-176 610.00
IUUC-Ttr-129036 Tursiops truncatus 81.44 0.00e+00 731.00
Created Date 25-Jun-2017

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