iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013166

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

DAAA02000497

Gene Name

USP25

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000019314.4	ENSBTAT00000025716.4	ENSBTAP00000025716.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.30e-63	213.1	167	653

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs 85
           +GlkN+gNtC++ +v+Q+L+n+ e+r+l+l+    ++ ++l+++++++++ +++++l+ lf+ l+ +k+k+v+p++ +++lk++ ++ +
   Q: 167  VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNykppSNVQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKS-N 254
           6******************************97777777777788888888*******************************99997.9 PP
   S: 86   gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
            ++qqD++Ef++ lld le+++++                  + +ee ++ k k+++++lF g++    + +  +++ + +e f +++l
   Q: 255  DSQQQDVSEFTHKLLDWLEDAFQM------------------KAEEETDEDKPKNPMVELFYGRFLAVGVLE--GKKFENTEMFGQYPL 323
           **********************33..................122355778999************777664..444556899****** PP
   S: 175  pvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           +v+g +     +l++cLe+ + e e+e+   +++e+  k+    +++++++lP+vL+++L+Rf+f+++ +++eki++k+efp+ L l++
   Q: 324  QVNGFK-----DLHECLEAAMIEGEIES---LHSENSGKS---GQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDR 401
           ******.....9**************96...999998865...589******************************************* PP
   S: 264  fcts..................................................................................... 267
           ++++                                                                                     
   Q: 402  YMHRnreitrikreeikrlkdyltvlqqrlerylsygsgpkrfplvdvlqyalefasskpvctspvddidasspssgsvpsqtlpsttd 490
           ****8888888888888888888888888888888888888888888888887777777777777777777777777777777765555 PP
   S: 268  ....peekqke.............................................................................. 274
               p     +                                                                              
   Q: 491  qqgaP-----Sselpstspasiaaissrsvihkpftqsrippdlpmhpaprhiteeelsvlesclhrwrteiendtrdlqesisrihrt 574
           55550.....0555555555566666666666666666666666666666666666666677777777777777777777888888888 PP
   S: 275  ...........kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                      ++ Y+L+av+vH+G+++ GHY+ay+ +++++ W++++D  Vt++++ee ++++      ++aY+l+Y 
   Q: 575  ielmysdksmiQVPYRLHAVLVHEGQANAGHYWAYIFDHRENrWMKYNDIAVTKSSWEELVRDSFggyrnASAYCLMYI 653
           88888888888**************************965556***************99997779************6 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

IHQTGKNQSA FRNHQQTFLN QLREITGIND AQILQQALKD SNGNLELAVA FLTAKNAKTP 60
QQEETTYYQT ALPGNDRYIS VGSQADTNVI DLTGDDKDDL QRAIALSLAE SNRAFRETGI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATACATCAGA CAGGGAAGAA TCAATCAGCT TTTAGAAACG TGAAAATGGA ATAAGGACTC 60
ACACAGCGTG GTTTATTCTT CCTAAAATAA TGAAATTTTT TCAGTCTTTC TCAAGTTCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR003903--UIM_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904293--P:negative regulation of ERAD pathway
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001340	Ailuropoda melanoleuca	93.54	0.00e+00	1969.00
IUUC-Apl-004030	Anas platyrhynchos	83.66	0.00e+00	1816.00
IUUC-Aca-004753	Anolis carolinensis	65.85	0.00e+00	998.00
IUUC-Afu-008871	Aspergillus fumigatus	23.94	1.00e-13	72.80
IUUC-Ani-009503	Aspergillus nidulans	33.96	2.00e-11	65.50
IUUC-Ame-010624	Astyanax mexicanus	71.07	0.00e+00	1078.00
IUUC-Cel-018346	Caenorhabditis elegans	28.17	7.00e-29	123.00
IUUC-Cja-019150	Callithrix jacchus	96.65	0.00e+00	1420.00
IUUC-Cfa-020649	Canis familiaris	96.26	0.00e+00	1441.00
IUUC-Cpo-021807	Cavia porcellus	92.44	0.00e+00	2041.00
IUUC-Csa-023388	Chlorocebus sabaeus	97.77	0.00e+00	1445.00
IUUC-Cho-024343	Choloepus hoffmanni	83.57	0.00e+00	980.00
IUUC-Cin-025302	Ciona intestinalis	37.17	5.00e-96	345.00
IUUC-Cgl-026575	Colletotrichum gloeosporioides	55.32	1.00e-10	62.40
IUUC-Dre-028016	Danio rerio	76.49	0.00e+00	1171.00
IUUC-Dno-029495	Dasypus novemcinctus	92.66	0.00e+00	1421.00
IUUC-Dor-030948	Dipodomys ordii	82.02	0.00e+00	1433.00
IUUC-Fca-035876	Felis catus	97.11	0.00e+00	2006.00
IUUC-Fal-036762	Ficedula albicollis	84.23	0.00e+00	1115.00
IUUC-Gmo-039490	Gadus morhua	72.08	0.00e+00	1516.00
IUUC-Gga-040817	Gallus gallus	86.13	0.00e+00	1346.00
IUUC-Gac-042473	Gasterosteus aculeatus	72.23	0.00e+00	1545.00
IUUC-Ggo-044939	Gorilla gorilla	91.89	0.00e+00	1893.00
IUUC-Hsa-046204	Homo sapiens	96.39	0.00e+00	1957.00
IUUC-Kpa-049349	Komagataella pastoris	28.12	5.00e-10	60.80
IUUC-Lch-049572	Latimeria chalumnae	79.35	0.00e+00	1218.00
IUUC-Loc-052070	Lepisosteus oculatus	75.68	0.00e+00	1202.00
IUUC-Lma-053078	Leptosphaeria maculans	30.56	5.00e-12	67.40
IUUC-Laf-054426	Loxodonta africana	96.69	0.00e+00	1837.00
IUUC-Mcc-055858	Macaca mulatta	96.78	0.00e+00	1454.00
IUUC-Mga-059808	Meleagris gallopavo	86.04	0.00e+00	1823.00
IUUC-Mmr-060987	Microcebus murinus	97.16	0.00e+00	1428.00
IUUC-Mmu-064245	Mus musculus	92.40	0.00e+00	1967.00
IUUC-Mpu-066304	Mustela putorius furo	96.87	0.00e+00	1432.00
IUUC-Mlu-067139	Myotis lucifugus	96.15	0.00e+00	2009.00
IUUC-Nle-069075	Nomascus leucogenys	96.39	0.00e+00	1952.00
IUUC-Ont-072150	Oreochromis niloticus	75.12	0.00e+00	1177.00
IUUC-Oan-073054	Ornithorhynchus anatinus	80.17	0.00e+00	1686.00
IUUC-Ocu-074102	Oryctolagus cuniculus	93.28	0.00e+00	1430.00
IUUC-Ola-086529	Oryzias latipes	69.27	0.00e+00	1474.00
IUUC-Oga-088939	Otolemur garnettii	96.92	0.00e+00	1993.00
IUUC-Oar-090266	Ovis aries	99.09	0.00e+00	1456.00
IUUC-Ptr-090546	Pan troglodytes	96.20	0.00e+00	1952.00
IUUC-Pan-092311	Papio anubis	96.65	0.00e+00	1453.00
IUUC-Psi-093459	Pelodiscus sinensis	90.85	0.00e+00	1171.00
IUUC-Pfo-096726	Poecilia formosa	74.50	0.00e+00	1162.00
IUUC-Pab-097608	Pongo abelii	94.31	0.00e+00	1929.00
IUUC-Pca-100718	Procavia capensis	92.32	0.00e+00	1242.00
IUUC-Pva-103150	Pteropus vampyrus	92.83	0.00e+00	1476.00
IUUC-Pte-104300	Pyrenophora teres	38.96	2.00e-11	65.50
IUUC-Rno-105727	Rattus norvegicus	93.35	0.00e+00	1929.00
IUUC-Sha-107051	Sarcophilus harrisii	88.19	0.00e+00	1852.00
IUUC-Sar-113097	Sorex araneus	86.46	0.00e+00	1816.00
IUUC-Sre-115145	Sporisorium reilianum	26.07	7.00e-11	63.90
IUUC-Ssc-115877	Sus scrofa	95.95	0.00e+00	1990.00
IUUC-Tgu-117473	Taeniopygia guttata	78.86	0.00e+00	1684.00
IUUC-Tru-118135	Takifugu rubripes	67.07	0.00e+00	1395.00
IUUC-Tsy-119471	Tarsius syrichta	89.29	0.00e+00	1779.00
IUUC-Tni-120139	Tetraodon nigroviridis	68.81	0.00e+00	1315.00
IUUC-Tbe-127549	Tupaia belangeri	90.38	0.00e+00	1874.00
IUUC-Ttr-128896	Tursiops truncatus	91.55	0.00e+00	1911.00
IUUC-Vpa-130500	Vicugna pacos	94.69	0.00e+00	1345.00
IUUC-Xtr-132896	Xenopus tropicalis	81.07	0.00e+00	1719.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence