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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105707
UUCD1 version UUC-RaN-00804
Ensembl Protein ID ENSRNOP00000029229.3
UniProt Accession Q4KLI9; F8WFL5; FBXW5_RAT
Genbank Protein ID AAH99179.1
Protein Name F-box/WD repeat-containing protein 5; F-box and WD-40 domain-containing protein 5
Genbank Nucleotide ID BC099179
Gene Name Fbxw5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000028674.6 ENSRNOT00000034089.5 ENSRNOP00000029229.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACmiRNAMapRAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.00e-12 48.1 91 120
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWD 29
           Htd v  l+f  s+  ++s+s D+t+k+W+
   Q: 91   HTDQVLHLSFshSGYQFASCSKDCTVKIWN 120
           9*********955588*************9 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway (By similarity).
 Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway (By similarity).
Protein Sequence
(Fasta)
MDEGGMPLLP DSLVYQIFLS LGPADVLAAG LVCRQWQAVS RDEFLWREQF YRYYQVARDV 60
PRHPAATSWY EEFRRLYDMV PCVEVQTLKE HTDQVLHLSF SHSGYQFASC SKDCTVKIWN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105707|E3,WD_repeat|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTCTCTCCTG AAGCCACACG ACAGCCATTG GGCAGCAGGA GCCCCTTCTC AGAAGAAAGT 60
TAGCCCTGAC CTGAAGTCCT GTGGCAGCAA GGTCAAAGAC AGGGTGAGGT GCTAAAACTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105707|E3,WD_repeat|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR001810--F-box_dom
IPR027295--Quinoprotein_ADH-like_fam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50181--FBOX
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12937--F-box-like
PF00400--WD40
SMART

SM00256--FBOX
SM00320--WD40
Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0000151--C:ubiquitin ligase complex
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0010824--P:regulation of centrosome duplication
GO:0007088--P:regulation of mitotic nuclear division
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
KEGG rno:362081
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001942 Ailuropoda melanoleuca 90.02 0.00e+00 998.00
IUUC-Apl-003274 Anas platyrhynchos 76.48 0.00e+00 767.00
IUUC-Aca-004626 Anolis carolinensis 60.83 7.00e-98 350.00
IUUC-Ame-011823 Astyanax mexicanus 59.83 2.00e-176 612.00
IUUC-Bta-012523 Bos taurus 89.30 0.00e+00 1003.00
IUUC-Cja-018729 Callithrix jacchus 90.40 0.00e+00 1051.00
IUUC-Cfa-020303 Canis familiaris 89.67 0.00e+00 1021.00
IUUC-Cpo-022134 Cavia porcellus 92.97 0.00e+00 1076.00
IUUC-Csa-023253 Chlorocebus sabaeus 90.37 0.00e+00 1065.00
IUUC-Cin-025742 Ciona intestinalis 34.68 2.00e-84 306.00
IUUC-Dre-027511 Danio rerio 67.00 0.00e+00 726.00
IUUC-Dno-029044 Dasypus novemcinctus 86.34 0.00e+00 996.00
IUUC-Dor-030565 Dipodomys ordii 91.21 0.00e+00 1049.00
IUUC-Dme-031713 Drosophila melanogaster 40.33 1.00e-126 447.00
IUUC-Eca-033709 Equus caballus 88.75 0.00e+00 1010.00
IUUC-Eeu-035093 Erinaceus europaeus 96.69 6.00e-103 367.00
IUUC-Fca-035674 Felis catus 88.46 0.00e+00 1024.00
IUUC-Fal-037104 Ficedula albicollis 73.79 0.00e+00 813.00
IUUC-Gmo-039041 Gadus morhua 62.57 0.00e+00 654.00
IUUC-Gga-041230 Gallus gallus 74.36 0.00e+00 868.00
IUUC-Gac-042594 Gasterosteus aculeatus 62.06 0.00e+00 658.00
IUUC-Ggo-044486 Gorilla gorilla 89.49 0.00e+00 1028.00
IUUC-Hsa-045701 Homo sapiens 89.32 0.00e+00 1026.00
IUUC-Itr-048811 Ictidomys tridecemlineatus 93.85 0.00e+00 1100.00
IUUC-Kpa-049204 Komagataella pastoris 31.88 1.00e-06 48.50
IUUC-Lch-050058 Latimeria chalumnae 69.95 0.00e+00 824.00
IUUC-Loc-052525 Lepisosteus oculatus 69.84 0.00e+00 724.00
IUUC-Laf-054120 Loxodonta africana 87.96 0.00e+00 1011.00
IUUC-Mcc-054915 Macaca mulatta 90.37 0.00e+00 1035.00
IUUC-Meu-056715 Macropus eugenii 76.17 0.00e+00 888.00
IUUC-Mga-059831 Meleagris gallopavo 74.67 0.00e+00 775.00
IUUC-Mvi-060236 Microbotryum violaceum 37.18 9.00e-08 53.10
IUUC-Mmr-060655 Microcebus murinus 90.03 0.00e+00 1044.00
IUUC-Mdo-062641 Monodelphis domestica 81.83 0.00e+00 945.00
IUUC-Mmu-063471 Mus musculus 97.73 0.00e+00 1142.00
IUUC-Mpu-066586 Mustela putorius furo 88.27 0.00e+00 1016.00
IUUC-Nle-069429 Nomascus leucogenys 89.67 0.00e+00 1056.00
IUUC-Ont-071780 Oreochromis niloticus 65.98 0.00e+00 706.00
IUUC-Ola-086458 Oryzias latipes 66.55 0.00e+00 723.00
IUUC-Oga-088739 Otolemur garnettii 89.53 0.00e+00 1055.00
IUUC-Oar-089275 Ovis aries 94.19 3.00e-47 179.00
IUUC-Ptr-090716 Pan troglodytes 87.94 0.00e+00 844.00
IUUC-Pan-092182 Papio anubis 81.96 0.00e+00 907.00
IUUC-Psi-093449 Pelodiscus sinensis 74.83 0.00e+00 863.00
IUUC-Pma-094289 Petromyzon marinus 53.82 3.00e-176 611.00
IUUC-Pfo-096062 Poecilia formosa 66.32 0.00e+00 718.00
IUUC-Pab-098726 Pongo abelii 88.44 0.00e+00 1022.00
IUUC-Pca-100163 Procavia capensis 81.05 3.00e-87 315.00
IUUC-Pva-103051 Pteropus vampyrus 88.10 3.00e-138 485.00
IUUC-Sha-107074 Sarcophilus harrisii 82.54 0.00e+00 894.00
IUUC-Ssc-116020 Sus scrofa 88.37 0.00e+00 837.00
IUUC-Tgu-116683 Taeniopygia guttata 71.07 4.00e-99 353.00
IUUC-Tru-118143 Takifugu rubripes 66.27 0.00e+00 712.00
IUUC-Tni-120777 Tetraodon nigroviridis 65.93 0.00e+00 716.00
IUUC-Ttr-128439 Tursiops truncatus 89.10 0.00e+00 1014.00
IUUC-Xtr-132774 Xenopus tropicalis 56.83 5.00e-145 507.00
Created Date 25-Jun-2017

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