iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ocu-074758

Ensembl Protein ID

ENSOCUP00000004548.2

UniProt Accession

G1SNI3; G1SNI3_RABIT

Protein Name

Histone-lysine N-methyltransferase

Gene Name

WHSC1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000005245.2	ENSOCUT00000005247.2	ENSOCUP00000004548.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	2.10e-15	56.7	828	868

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC +gg+    l++Ce C  +fHp+Cl++     +p+ + w+C++Cr
   Q: 828  WCFVCSKGGS----LLCCESCPAAFHPDCLNID----MPDGS-WFCNDCR 868
           8*********....*******************....9***8.******8 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MEFSIKKSPL SVQKVVKCIK MKQAPEILGG ANGKTQNCEV NRDCSVFLSK AQLSSSIQEG 60
VMQKFNGRDA LPFIPAEKLK DLTSRVFNGE PGAHDAKLRF ESQEMKGIGT PPNTTPIKNG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAATTTA GCATCAAAAA AAGTCCTCTT TCTGTTCAGA AAGTTGTAAA GTGCATAAAG 60
ATGAAGCAGG CACCAGAAAT CCTTGGTGGT GCGAACGGAA AGACCCAGAA CTGCGAGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006560--AWS_dom
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51215--AWS
PS50118--HMG_BOX_2
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS50089--ZF_RING_2

Pfam

PF00505--HMG_box
PF00855--PWWP
PF00856--SET

SMART

SM00570--AWS
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00184--RING
SM00317--SET

Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0043565--F:sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0003289--P:atrial septum primum morphogenesis
GO:0003290--P:atrial septum secundum morphogenesis
GO:0060348--P:bone development
GO:0010452--P:histone H3-K36 methylation
GO:0034770--P:histone H4-K20 methylation
GO:0003149--P:membranous septum morphogenesis
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048298--P:positive regulation of isotype switching to IgA isotypes
GO:2001032--P:regulation of double-strand break repair via nonhomologous end joining
GO:0070201--P:regulation of establishment of protein localization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002181	Ailuropoda melanoleuca	88.49	0.00e+00	2291.00
IUUC-Apl-003677	Anas platyrhynchos	78.52	0.00e+00	2046.00
IUUC-Aca-004278	Anolis carolinensis	74.67	0.00e+00	1369.00
IUUC-Ame-011932	Astyanax mexicanus	69.83	0.00e+00	1003.00
IUUC-Bta-012522	Bos taurus	81.86	0.00e+00	2098.00
IUUC-Cja-018908	Callithrix jacchus	88.75	0.00e+00	2264.00
IUUC-Cfa-020894	Canis familiaris	88.05	0.00e+00	2344.00
IUUC-Cpo-021982	Cavia porcellus	88.10	0.00e+00	2286.00
IUUC-Csa-023807	Chlorocebus sabaeus	88.10	0.00e+00	2270.00
IUUC-Cho-024405	Choloepus hoffmanni	71.22	0.00e+00	692.00
IUUC-Csv-026298	Ciona savignyi	39.57	2.00e-58	219.00
IUUC-Dre-027492	Danio rerio	69.93	0.00e+00	1051.00
IUUC-Dno-030020	Dasypus novemcinctus	85.69	0.00e+00	1976.00
IUUC-Dor-031103	Dipodomys ordii	81.37	0.00e+00	2031.00
IUUC-Ete-032488	Echinops telfairi	79.91	0.00e+00	2008.00
IUUC-Eca-034066	Equus caballus	88.68	0.00e+00	2345.00
IUUC-Eeu-035199	Erinaceus europaeus	69.26	0.00e+00	730.00
IUUC-Fca-035434	Felis catus	83.97	0.00e+00	1881.00
IUUC-Fal-037113	Ficedula albicollis	76.84	0.00e+00	2040.00
IUUC-Gmo-039686	Gadus morhua	69.65	0.00e+00	992.00
IUUC-Gga-040273	Gallus gallus	76.56	0.00e+00	2024.00
IUUC-Gac-042123	Gasterosteus aculeatus	50.45	0.00e+00	1195.00
IUUC-Ggo-044643	Gorilla gorilla	89.78	0.00e+00	2310.00
IUUC-Hsa-046380	Homo sapiens	89.71	0.00e+00	2267.00
IUUC-Itr-048658	Ictidomys tridecemlineatus	90.76	0.00e+00	1407.00
IUUC-Lch-050217	Latimeria chalumnae	67.29	0.00e+00	1685.00
IUUC-Loc-052766	Lepisosteus oculatus	66.67	0.00e+00	1107.00
IUUC-Laf-053780	Loxodonta africana	86.35	0.00e+00	2295.00
IUUC-Mcc-054928	Macaca mulatta	88.24	0.00e+00	2309.00
IUUC-Meu-056184	Macropus eugenii	74.09	0.00e+00	766.00
IUUC-Mga-059576	Meleagris gallopavo	77.26	0.00e+00	2025.00
IUUC-Mmr-061045	Microcebus murinus	88.75	0.00e+00	2346.00
IUUC-Mdo-062576	Monodelphis domestica	80.34	0.00e+00	2108.00
IUUC-Mmu-063640	Mus musculus	87.45	0.00e+00	2239.00
IUUC-Mpu-066512	Mustela putorius furo	88.21	0.00e+00	2274.00
IUUC-Mlu-067280	Myotis lucifugus	78.76	0.00e+00	1077.00
IUUC-Nle-069896	Nomascus leucogenys	89.60	0.00e+00	2196.00
IUUC-Ont-072197	Oreochromis niloticus	71.70	0.00e+00	1018.00
IUUC-Oan-072724	Ornithorhynchus anatinus	79.46	0.00e+00	1337.00
IUUC-Oga-088702	Otolemur garnettii	89.79	0.00e+00	2035.00
IUUC-Oar-089736	Ovis aries	77.70	0.00e+00	1863.00
IUUC-Ptr-091055	Pan troglodytes	88.02	0.00e+00	2266.00
IUUC-Pan-092752	Papio anubis	94.69	0.00e+00	1386.00
IUUC-Psi-093620	Pelodiscus sinensis	78.86	0.00e+00	2058.00
IUUC-Pfo-097464	Poecilia formosa	50.45	0.00e+00	1189.00
IUUC-Pab-098051	Pongo abelii	89.48	0.00e+00	2297.00
IUUC-Pca-100273	Procavia capensis	85.31	0.00e+00	2226.00
IUUC-Pva-102473	Pteropus vampyrus	77.32	0.00e+00	1873.00
IUUC-Rno-105056	Rattus norvegicus	87.80	0.00e+00	2243.00
IUUC-Sha-107494	Sarcophilus harrisii	80.70	0.00e+00	2083.00
IUUC-Sar-113310	Sorex araneus	88.17	0.00e+00	1778.00
IUUC-Sbi-114581	Sorghum bicolor	34.26	3.00e-09	55.50
IUUC-Ssc-116344	Sus scrofa	81.07	0.00e+00	2139.00
IUUC-Tgu-116786	Taeniopygia guttata	78.14	0.00e+00	2043.00
IUUC-Tru-117638	Takifugu rubripes	49.51	0.00e+00	1190.00
IUUC-Tsy-118937	Tarsius syrichta	91.92	0.00e+00	1488.00
IUUC-Tni-120452	Tetraodon nigroviridis	62.62	0.00e+00	1033.00
IUUC-Tae-125237	Triticum aestivum	40.23	4.00e-07	48.50
IUUC-Tbe-127291	Tupaia belangeri	84.52	0.00e+00	1472.00
IUUC-Ttr-129017	Tursiops truncatus	80.75	0.00e+00	1670.00
IUUC-Xtr-132673	Xenopus tropicalis	65.91	0.00e+00	1712.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence