iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-021245

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03013522

Gene Name

KLHL40

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000005343.3	ENSCAFT00000008605.3	ENSCAFP00000007974.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	3.80e-15	56.3	34	97
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	6.30e-06	25.5	131	160

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 2    DvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           D+++ vg++ef++h++vLaa+S++F+a fl e e     ++  +++v+p+v+ ++l++lYt+++ ++
   Q: 34   DCVVRVGEREFPCHRLVLAACSPYFRARFLAEPERA---GELRLEEVSPDVVAQVLHYLYTSEIALD 97
           9****************************9988864...699999*****************99876 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 2    eNclgilrfAdlydcpdLkdaaldfilkhF 31
            Ncl+++r++ l+dc +L+ aa+dfi+  F
   Q: 131  ANCLAVFRLGLLLDCARLAVAARDFICARF 160
           6**************************999 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MTLGLEQAEE QRLYQQTLLQ DGLKDMLDHG KFLDCVVRVG EREFPCHRLV LAACSPYFRA 60
RFLAEPERAG ELRLEEVSPD VVAQVLHYLY TSEIALDEAS VQDLFAAAHR FQIPSIFTIC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTGCGGAG ACAGCTGCGG AGACTGCGTG ACCCAGAAGG AAAGCAGGGG ACCAGCGAGA 60
GCAGGCCCCC GAGCCACCCA CCATGACGCT GGGCTTGGAG CAGGCGGAGG AGCAGCGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR030607--KLHL40
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB

SMART

SM00875--BACK
SM00225--BTB

Gene Ontology

GO:0031672--C:A band
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0031674--C:I band
GO:0032435--P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031397--P:negative regulation of protein ubiquitination
GO:0016567--P:protein ubiquitination
GO:0048741--P:skeletal muscle fiber development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001792	Ailuropoda melanoleuca	92.63	0.00e+00	732.00
IUUC-Aca-005275	Anolis carolinensis	68.97	0.00e+00	629.00
IUUC-Acl-008133	Aspergillus clavatus	33.87	2.00e-04	41.20
IUUC-Ani-009446	Aspergillus nidulans	27.47	4.00e-04	38.50
IUUC-Bta-012801	Bos taurus	91.70	0.00e+00	796.00
IUUC-Cja-019795	Callithrix jacchus	89.91	0.00e+00	750.00
IUUC-Cpo-022436	Cavia porcellus	86.77	0.00e+00	786.00
IUUC-Csa-023105	Chlorocebus sabaeus	90.58	0.00e+00	797.00
IUUC-Dno-030015	Dasypus novemcinctus	79.19	0.00e+00	632.00
IUUC-Eca-034393	Equus caballus	90.58	0.00e+00	760.00
IUUC-Fca-035823	Felis catus	87.24	0.00e+00	701.00
IUUC-Ggo-045596	Gorilla gorilla	89.91	0.00e+00	796.00
IUUC-Hsa-046235	Homo sapiens	89.91	0.00e+00	796.00
IUUC-Itr-048612	Ictidomys tridecemlineatus	92.60	0.00e+00	799.00
IUUC-Laf-053485	Loxodonta africana	88.57	0.00e+00	725.00
IUUC-Mcc-054909	Macaca mulatta	90.13	0.00e+00	797.00
IUUC-Meu-055972	Macropus eugenii	74.73	0.00e+00	666.00
IUUC-Mmr-060736	Microcebus murinus	89.24	0.00e+00	792.00
IUUC-Mdo-062563	Monodelphis domestica	77.13	0.00e+00	688.00
IUUC-Mmu-063549	Mus musculus	91.26	0.00e+00	781.00
IUUC-Mpu-066262	Mustela putorius furo	93.27	0.00e+00	814.00
IUUC-Mlu-067210	Myotis lucifugus	88.57	0.00e+00	782.00
IUUC-Nle-069300	Nomascus leucogenys	90.52	0.00e+00	787.00
IUUC-Opr-070384	Ochotona princeps	84.08	0.00e+00	701.00
IUUC-Ocu-074499	Oryctolagus cuniculus	91.05	0.00e+00	800.00
IUUC-Oga-088855	Otolemur garnettii	88.57	0.00e+00	786.00
IUUC-Oar-089342	Ovis aries	77.65	4.00e-179	621.00
IUUC-Ptr-091028	Pan troglodytes	89.82	0.00e+00	788.00
IUUC-Pan-091827	Papio anubis	90.13	0.00e+00	797.00
IUUC-Pab-097656	Pongo abelii	88.62	0.00e+00	657.00
IUUC-Pva-102331	Pteropus vampyrus	91.48	0.00e+00	799.00
IUUC-Pte-104085	Pyrenophora teres	35.29	6.00e-05	41.60
IUUC-Pyt-104655	Pyrenophora triticirepentis	35.29	6.00e-05	42.00
IUUC-Rno-105613	Rattus norvegicus	90.36	0.00e+00	769.00
IUUC-Sar-112941	Sorex araneus	90.48	9.00e-176	609.00
IUUC-Ssc-116276	Sus scrofa	92.83	0.00e+00	806.00
IUUC-Tsy-119499	Tarsius syrichta	87.96	0.00e+00	650.00
IUUC-Tbe-127806	Tupaia belangeri	89.01	0.00e+00	793.00
IUUC-Ttr-128813	Tursiops truncatus	91.48	0.00e+00	791.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence